Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation

Vara-Ciruelos, Diana; Dandapani, Madhumita; Russell, Fiona M.; Grzes, Katarzyna M.; Atrih, Abdelmadjid; Foretz, Marc; Viollet, Benoit; Lamont, Douglas J.; Cantrell, Doreen A.; Hardie, D. Grahame

doi:10.1016/j.celrep.2019.03.067

Research Repository

All Outputs (2)

AMP-Activated Protein Kinase: Friend or Foe in Cancer? (2019)
Journal Article

The AMP-activated protein kinase (AMPK) is activated by energy stress and restores homeostasis by switching on catabolism, while switching off cell growth and proliferation. Findings that AMPK acts downstream of the tumor suppressor LKB1 have suggest... Read More about AMP-Activated Protein Kinase: Friend or Foe in Cancer?.

Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation (2019)
Journal Article

AMPK acts downstream of the tumor suppressor LKB1, yet its role in cancer has been controversial. AMPK is activated by biguanides, such as metformin and phenformin, and metformin use in diabetics has been associated with reduced cancer risk. However... Read More about Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation.