All Outputs (46)

Quality of life in older adults with chronic kidney disease and transient changes in renal function: Findings from the Oxford Renal cohort (2022)
Journal Article

BACKGROUND: Quality of life (QoL) is an important measure of disease burden and general health perception. The relationship between early chronic kidney disease (CKD) and QoL remains poorly understood. The Oxford Renal Study (OxRen) cohort comprises... Read More about Quality of life in older adults with chronic kidney disease and transient changes in renal function: Findings from the Oxford Renal cohort.

Room for improvement: diagnosing and managing acute coronary syndromes in persons with reduced eGFR (2022)
Journal Article

Cardiovascular events are the leading cause of death in chronic kidney disease. A recent analysis from the High-Sensitivity Troponin in the Evaluation of Patients With Suspected Acute Coronary Syndrome trial focused on results in those with reduced e... Read More about Room for improvement: diagnosing and managing acute coronary syndromes in persons with reduced eGFR.

Defining improvement in chronic kidney disease: regression and remission (2022)
Journal Article

Purpose of review: International definitions exist for chronic kidney disease (CKD) progression and kidney failure but despite evidence that kidney function may improve, there are no agreed definitions for regression and remission of CKD. In the ligh... Read More about Defining improvement in chronic kidney disease: regression and remission.

Simple, high-throughput measurement of gut-derived short-chain fatty acids in clinically relevant biofluids using gas chromatography-mass spectrometry (2022)
Journal Article

Introduction The quantitative measurement of circulating gut bacteria-derived metabolites has increased in recent years due to their associations with health and disease. While much of the previous attention has been placed on metabolites consider... Read More about Simple, high-throughput measurement of gut-derived short-chain fatty acids in clinically relevant biofluids using gas chromatography-mass spectrometry.

Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum (2021)
Journal Article

OBJECTIVE: To develop and validate a prognostic model for LEF discontinuation with abnormal blood test results. METHODS: Data from the Clinical Practice Research Datalink Gold and Aurum were used for model development and external validation, respect... Read More about Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum.

Impact of malnutrition on health-related quality of life in persons receiving dialysis: a prospective study (2021)
Journal Article

Health-related quality of life (HRQoL) is severely impaired in persons receiving dialysis. Malnutrition has been associated with some measures of poor HRQoL in cross-sectional analyses in dialysis populations, but no studies have assessed the impact... Read More about Impact of malnutrition on health-related quality of life in persons receiving dialysis: a prospective study.

What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline? (2021)
Journal Article

Objectives: To examine incidence of treatment changes due to abnormal blood-test results and, to explore rates of treatment changes due to liver, kidney and haematological blood-test abnormalities in autoimmune rheumatic diseases (AIRD) treated with... Read More about What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?.

Multiparametric MRI assessment of renal structure and function in acute kidney injury and renal recovery (2021)
Journal Article

Background: Acute Kidney Injury (AKI) is associated with a marked increase in mortality as well as subsequent chronic kidney disease (CKD) and end stage kidney disease. We performed multiparametric MRI with the aim of identifying potential non-invasi... Read More about Multiparametric MRI assessment of renal structure and function in acute kidney injury and renal recovery.

Patients' and kidney care team's perspectives of treatment burden and capacity in older people with chronic kidney disease: A qualitative study (2020)
Journal Article

Objective Chronic kidney disease (CKD) is often a multimorbid condition and progression to more severe disease is commonly associated with increased management requirements, including lifestyle change, more medication and greater clinician involvemen... Read More about Patients' and kidney care team's perspectives of treatment burden and capacity in older people with chronic kidney disease: A qualitative study.

Iterative Run-to-Run Learning Model to Derive Continuous Brachial Pressure Estimates from Arterial and Venous Lines During Dialysis Treatment (2020)
Journal Article

Objective: Non-invasive continuous blood pressure monitoring is not yet part of routine practice in renal dialysis units but could be a valuable tool in the detection and prevention of significant variations in patient blood pressure during treatment... Read More about Iterative Run-to-Run Learning Model to Derive Continuous Brachial Pressure Estimates from Arterial and Venous Lines During Dialysis Treatment.

A Feasibility Study of Non-Invasive Continuous Estimation of Brachial Pressure Derived from Arterial and Venous Lines During Dialysis (2020)
Journal Article

Objective: Intradialytic haemodynamic instability is a significant clinical problem, leading to end-organ ischaemia and contributing to morbidity and mortality in haemodialysis patients. Non-invasive continuous blood pressure monitoring is not curren... Read More about A Feasibility Study of Non-Invasive Continuous Estimation of Brachial Pressure Derived from Arterial and Venous Lines During Dialysis.

Acute kidney injury associated with COVID-19: A retrospective cohort study (2020)
Journal Article

Background Initial reports indicate a high incidence of acute kidney injury (AKI) in Coronavirus Disease 2019 (COVID-19), but more data are required to clarify if COVID-19 is an independent risk factor for AKI and how COVID-19–associated AKI may diff... Read More about Acute kidney injury associated with COVID-19: A retrospective cohort study.

Symptom-burden in people living with frailty and chronic kidney disease (2020)
Journal Article

Background: Frailty is independently associated with worse health-related quality of life (HRQOL) in chronic kidney disease (CKD). However, the relationship between frailty and symptom experience is not well described in people living with CKD. This... Read More about Symptom-burden in people living with frailty and chronic kidney disease.

The PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease trial: study design and baseline data for a multicentre randomized controlled trial (2020)
Journal Article

Background Exercise interventions designed to improve physical function and reduce sedentary behaviour in haemodialysis (HD) patients might improve exercise capacity, reduce fatigue and lead to improved quality of life (QOL). The PrEscription of int... Read More about The PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease trial: study design and baseline data for a multicentre randomized controlled trial.

Nutritional status assessment: a neglected biomarker in persons with end- stage kidney disease (2020)
Journal Article

Purpose of review: Malnutrition is a frequent complication and risk factor for adverse outcomes in the dialysis population that is often underrecognized and neglected. This article reviews published literature on the associations between malnutrition... Read More about Nutritional status assessment: a neglected biomarker in persons with end- stage kidney disease.

Prevalence of chronic kidney disease in adults in England: comparison of nationally representative cross-sectional surveys from 2003 to 2016 (2020)
Journal Article

Objectives: To identify recent trends in chronic kidney disease (CKD) prevalence in England and explore their association with changes in sociodemographic, behavioural and clinical factors. Design: Pooled cross-sectional analysis. Setting: Health... Read More about Prevalence of chronic kidney disease in adults in England: comparison of nationally representative cross-sectional surveys from 2003 to 2016.

Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study (2020)
Journal Article

Objectives: To determine the associations between comorbidities, health-related quality of life (HRQoL) and functional impairment in people with mild-to-moderate chronic kidney disease (CKD) in primary care. Design: Cross-sectional analysis at 5-y... Read More about Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study.

The association of skin autofluorescence with cardiovascular events and all-cause mortality in persons with chronic kidney disease stage 3: A prospective cohort study (2020)
Journal Article

Helping people to live well with chronic kidney disease (2020)
Journal Article

Reduced glomerular filtration rate and presence of albuminuria are both associated with increased risk of several poor outcomes. People with chronic kidney disease also commonly suffer from lower quality of life than their age-matched peers. The expe... Read More about Helping people to live well with chronic kidney disease.

Skin autofluorescence and malnutrition as predictors of mortality in persons receiving dialysis: a prospective cohort study (2020)
Journal Article

Background Skin autofluorescence (SAF), which is a measure of accumulation of advanced glycation end‐products (AGE), and malnutrition are each associated with higher mortality in dialysis populations, although no studies have investigated these po... Read More about Skin autofluorescence and malnutrition as predictors of mortality in persons receiving dialysis: a prospective cohort study.