All Outputs (13)

Pneumococcal serotypes and risk factors in adult community-acquired pneumonia 2018–20; a multicentre UK cohort study (2023)
Journal Article

Background: Higher-valency pneumococcal vaccines are anticipated. We aimed to describe serotype distribution and risk factors for vaccine-serotype community-acquired pneumonia (CAP) in the two years pre-SARS-CoV-2 pandemic. Methods: We conducted a pr... Read More about Pneumococcal serotypes and risk factors in adult community-acquired pneumonia 2018–20; a multicentre UK cohort study.

Non-invasive pneumococcal pneumonia due to vaccine serotypes: A systematic review and meta-analysis (2022)
Journal Article

Background Non-invasive pneumococcal pneumonia causes significant morbidity and mortality in older adults. Understanding pneumococcal sero-epidemiology in adults ≥50 years is necessary to inform vaccination policies and the updating of pneumococcal... Read More about Non-invasive pneumococcal pneumonia due to vaccine serotypes: A systematic review and meta-analysis.

Spotlight influenza: Laboratory-confirmed seasonal influenza in people with acute respiratory illness: a literature review and meta-analysis, WHO European Region, 2004 to 2017 (2021)
Journal Article

BackgroundAcross the World Health Organization European Region, there are few estimates of the proportion of people seeking medical care for influenza-like illness or acute respiratory infections and who have laboratory-confirmed seasonal influenza i... Read More about Spotlight influenza: Laboratory-confirmed seasonal influenza in people with acute respiratory illness: a literature review and meta-analysis, WHO European Region, 2004 to 2017.

Co-infection in critically ill patients with COVID-19: an observational cohort study from England (2021)
Journal Article

Introduction: During previous viral pandemics, reported co-infection rates and implicated pathogens have varied. In the 1918 influenza pandemic, a large proportion of severe illness and death was complicated by bacterial co-infection, predominantly S... Read More about Co-infection in critically ill patients with COVID-19: an observational cohort study from England.

Decline in seasonal influenza vaccine effectiveness with vaccination program maturation: A systematic review and meta-analysis (2021)
Journal Article

Objectives Evidence suggests repeated influenza vaccination may reduce vaccine effectiveness (VE). Using influenza vaccination program maturation (number of years since program inception) [PM] as proxy for population-level repeated vaccination, we... Read More about Decline in seasonal influenza vaccine effectiveness with vaccination program maturation: A systematic review and meta-analysis.

Co-infections in people with COVID-19: a systematic review and meta-analysis (2020)
Journal Article

Objectives: In previous influenza pandemics, bacterial co-infections have been a major cause of mortality. We aimed to evaluate the burden of co-infections in patients with COVID-19. Methods: We systematically searched Embase, Medline, Cochrane L... Read More about Co-infections in people with COVID-19: a systematic review and meta-analysis.

Point of care testing of Influenza A/B and RSV in an adult respiratory assessment unit is associated with improvement in isolation practices and reduction in hospital length of stay (2020)
Journal Article

Introduction. Every winter seasonal influenza and other viral respiratory infections increase pressure on the health services and are associated with nosocomial infection and morbidity. Aim. To compare provision of point-of-care (POC) testing with l... Read More about Point of care testing of Influenza A/B and RSV in an adult respiratory assessment unit is associated with improvement in isolation practices and reduction in hospital length of stay.

Corticosteroids as Adjunctive Therapy in the Treatment of Influenza: An Updated Cochrane Systematic Review and Meta-analysis (2019)
Journal Article

Objective: Corticosteroids may be beneficial in sepsis but uncertainty remains over their effects in severe influenza. This systematic review updates the current evidence regarding corticosteroids in the treatment of influenza and examines the effect... Read More about Corticosteroids as Adjunctive Therapy in the Treatment of Influenza: An Updated Cochrane Systematic Review and Meta-analysis.

Corticosteroids as adjunctive therapy in the treatment of influenza (2019)
Journal Article

Background Specific treatments for influenza are limited to neuraminidase inhibitors and adamantanes. Corticosteroids show evidence of benefit in sepsis and related conditions, most likely due to their anti‐inflammatory and immunomodulatory properti... Read More about Corticosteroids as adjunctive therapy in the treatment of influenza.

Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe (2017)
Journal Article

Community-acquired pneumonia (CAP) is an important respiratory disease and the fifth leading cause of mortality in Europe. The development of molecular diagnostic tests has highlighted the contributions of respiratory viruses to the aetiology of CAP,... Read More about Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe.

Influenza in long-term care facilities (2017)
Journal Article

Long-term care facility environments and the vulnerability of their residents provide a setting conducive to the rapid spread of influenza virus and other respiratory pathogens. Infections may be introduced by staff, visitors or new or transferred re... Read More about Influenza in long-term care facilities.

Effectiveness of 2009 pandemic influenza A(H1N1) vaccines: a systematic review and meta-analysis (2017)
Journal Article

Background: The clinical effectiveness of monovalent influenza A(H1N1)pdm09 vaccines has not been comprehensively summarised. We undertook a systematic review and meta-analysis to assess vaccine effectiveness (VE) for adjuvanted and unadjuvanted vacc... Read More about Effectiveness of 2009 pandemic influenza A(H1N1) vaccines: a systematic review and meta-analysis.

A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease (2016)
Journal Article

Background Skin diseases are very common and can have a large impact on the quality of life of patients and caregivers. This programme addressed four diseases: (1) eczema, (2) vitiligo, (3) squamous cell skin cancer (SCC) and (4) pyoderma gangreno... Read More about A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease.