All Outputs (31)

Supplementation with Citrus Low-Methoxy Pectin Reduces Levels of Inflammation and Anxiety in Healthy Volunteers: A Pilot Controlled Dietary Intervention Study (2024)
Journal Article
Vijay, A., Kelly, A., Miller, S., Marshall, M., Alonso, A., Kouraki, A., Probert, C., Simpson, E. J., & Valdes, A. M. (2024). Supplementation with Citrus Low-Methoxy Pectin Reduces Levels of Inflammation and Anxiety in Healthy Volunteers: A Pilot Controlled Dietary Intervention Study. Nutrients, 16(19), 3326. https://doi.org/10.3390/nu16193326

Background/Objective: Although low-methoxy (LM) pectin (polysaccharides extracted from citrus peels) can reduce inflammation by binding to and inhibiting the TLR-2 pathway in animal models and in vitro studies, the anti-inflammatory effects of LM pec... Read More about Supplementation with Citrus Low-Methoxy Pectin Reduces Levels of Inflammation and Anxiety in Healthy Volunteers: A Pilot Controlled Dietary Intervention Study.

Role of Eating Behavior and Stress in Maintenance of Dietary Changes During the PREVIEW Intervention (2024)
Journal Article
Jalo, E., Fogelholm, M., Westerterp-Plantenga, M., Adam, T. C., Drummen, M., Huttunen-Lenz, M., Kjølbæk, L., Martinez, J. A., Handjieva-Darlenska, T., Taylor, M. A., Brand-Miller, J., Poppitt, S., Stratton, G., Lam, T., Navas-Carretero, S., Bogdanov, G., Simpson, L., Muirhead, R., Silvestre, M. P., Swindell, N., …Konttinen, H. (2024). Role of Eating Behavior and Stress in Maintenance of Dietary Changes During the PREVIEW Intervention. Journal of Nutrition Education and Behavior, 56(5), 276-286. https://doi.org/10.1016/j.jneb.2024.01.001

Objective: To examine whether eating behavior and perceived stress predict the maintenance of self-reported dietary change and adherence to dietary instructions during an intervention. Design: A secondary analysis of the behavior maintenance stage (6... Read More about Role of Eating Behavior and Stress in Maintenance of Dietary Changes During the PREVIEW Intervention.

Associations of obesity phenotypes with weight change, cardiometabolic benefits, and type 2 diabetes incidence during a lifestyle intervention: results from the PREVIEW study (2023)
Journal Article
Zhu, R., Huttunen-Lenz, M., Stratton, G., Handjieva-Darlenska, T., Handjiev, S., Sundvall, J., Silvestre, M. P., Jalo, E., Pietiläinen, K. H., Adam, T. C., Drummen, M., Simpson, E. J., Taylor, M. A., Poppitt, S. D., Navas-Carretero, S., Martinez, J. A., Schlicht, W., Fogelholm, M., Brand-Miller, J., & Raben, A. (2023). Associations of obesity phenotypes with weight change, cardiometabolic benefits, and type 2 diabetes incidence during a lifestyle intervention: results from the PREVIEW study. International Journal of Obesity, 47(9), 833–840. https://doi.org/10.1038/s41366-023-01328-y

Background/Objectives
Some individuals with overweight/obesity may be relatively metabolically healthy (MHO) and have a lower risk of cardiovascular disease than those with metabolically unhealthy overweight/obesity (MUO). We aimed to compare change... Read More about Associations of obesity phenotypes with weight change, cardiometabolic benefits, and type 2 diabetes incidence during a lifestyle intervention: results from the PREVIEW study.

Longitudinal Associations of Dietary Sugars and Glycaemic Index with Indices of Glucose Metabolism and Body Fatness during 3-Year Weight Loss Maintenance: A PREVIEW Sub-Study (2023)
Journal Article
Della Corte, K., Jalo, E., Kaartinen, N. E., Simpson, L., Taylor, M. A., Muirhead, R., Raben, A., Macdonald, I. A., Fogelholm, M., & Brand-Miller, J. (2023). Longitudinal Associations of Dietary Sugars and Glycaemic Index with Indices of Glucose Metabolism and Body Fatness during 3-Year Weight Loss Maintenance: A PREVIEW Sub-Study. Nutrients, 15(9), Article 2083. https://doi.org/10.3390/nu15092083

Background: Dietary sugars are often linked to the development of overweight and type 2 diabetes (T2D) but inconsistencies remain. Objective: We investigated associations of added, free, and total sugars, and glycaemic index (GI) with indices of gluc... Read More about Longitudinal Associations of Dietary Sugars and Glycaemic Index with Indices of Glucose Metabolism and Body Fatness during 3-Year Weight Loss Maintenance: A PREVIEW Sub-Study.

The impact of physical inactivity on glucose homeostasis when diet is adjusted to maintain energy balance in healthy, young males (2023)
Journal Article
Trim, W. V., Walhin, J. P., Koumanov, F., Turner, J. E., Shur, N. F., Simpson, E. J., Macdonald, I. A., Greenhaff, P. L., & Thompson, D. (2023). The impact of physical inactivity on glucose homeostasis when diet is adjusted to maintain energy balance in healthy, young males. Clinical Nutrition, 42(4), 532-540. https://doi.org/10.1016/j.clnu.2023.02.006

Background & aims: It is unclear if dietary adjustments to maintain energy balance during reduced physical activity can offset inactivity-induced reductions in insulin sensitivity and glucose disposal to produce normal daily glucose concentrations an... Read More about The impact of physical inactivity on glucose homeostasis when diet is adjusted to maintain energy balance in healthy, young males.

Cocoa Flavanol Supplementation and the Effect on Insulin Resistance in Females Who Are Overweight or Obese: A Randomized, Placebo-Controlled Trial (2023)
Journal Article
Simpson, E. J., Mendis, B., Dunlop, M., Schroeter, H., Kwik-Uribe, C., & Macdonald, I. A. (2023). Cocoa Flavanol Supplementation and the Effect on Insulin Resistance in Females Who Are Overweight or Obese: A Randomized, Placebo-Controlled Trial. Nutrients, 15(3), Article 565. https://doi.org/10.3390/nu15030565

There is interest in the impact that dietary interventions can have on preventing the transition from insulin resistance to type 2 diabetes, including a suggestion that the bioactive components of cocoa may enhance fasting insulin sensitivity. Howeve... Read More about Cocoa Flavanol Supplementation and the Effect on Insulin Resistance in Females Who Are Overweight or Obese: A Randomized, Placebo-Controlled Trial.

Liver glycogen stores via 13C magnetic resonance spectroscopy in healthy children: randomized, controlled study (2023)
Journal Article
Horstman, A. M., Bawden, S. J., Spicer, A., Darwish, N., Goyer, A., Egli, L., Rupp, N., Minehira, K., Gowland, P., Breuillé, D., Macdonald, I. A., & Simpson, E. J. (2023). Liver glycogen stores via 13C magnetic resonance spectroscopy in healthy children: randomized, controlled study. American Journal of Clinical Nutrition, 117(4), 709-716. https://doi.org/10.1016/j.ajcnut.2023.01.014

Background: Owing to its role in glucose homeostasis, liver glycogen concentration ([LGly]) can be a marker of altered metabolism seen in disorders that impact the health of children. However, there is a paucity of normative data for this measure in... Read More about Liver glycogen stores via 13C magnetic resonance spectroscopy in healthy children: randomized, controlled study.

Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization (2022)
Journal Article
Shur, N. F., Simpson, E. J., Crossland, H., Chivaka, P. K., Constantin, D., Cordon, S. M., Constantin-Teodosiu, D., Stephens, F. B., Lobo, D. N., Szewczyk, N., Narici, M., Prats, C., Macdonald, I. A., & Greenhaff, P. L. (2022). Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization. Journal of Cachexia, Sarcopenia and Muscle, 13(6), 2999-3013. https://doi.org/10.1002/jcsm.13075

Background: Bed rest (BR) reduces whole-body insulin-stimulated glucose disposal (GD) and alters muscle fuel metabolism, but little is known about metabolic adaptation from acute to chronic BR nor the mechanisms involved, particularly when volunteers... Read More about Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization.

Does the Effect of a 3-Year Lifestyle Intervention on Body Weight and Cardiometabolic Health Differ by Prediabetes Metabolic Phenotype? A Post Hoc Analysis of the PREVIEW Study (2022)
Journal Article
Zhu, R., Jalo, E., Silvestre, M. P., Poppitt, S. D., Handjieva-Darlenska, T., Handjiev, S., Huttunen-Lenz, M., Mackintosh, K., Stratton, G., Navas-Carretero, S., Pietiläinen, K. H., Simpson, E., Macdonald, I. A., Muirhead, R., Brand-Miller, J., Fogelholm, M., Færch, K., Martinez, J. A., Westerterp-Plantenga, M. S., Adam, T. C., & Raben, A. (2022). Does the Effect of a 3-Year Lifestyle Intervention on Body Weight and Cardiometabolic Health Differ by Prediabetes Metabolic Phenotype? A Post Hoc Analysis of the PREVIEW Study. Diabetes Care, 45(11), 2698-2708. https://doi.org/10.2337/dc22-0549

OBJECTIVE: To examine whether the effect of a 3-year lifestyle intervention on body weight and cardiometabolic risk factors differs by prediabetes metabolic phenotype.

RESEARCH DESIGN AND METHODS: This post hoc analysis of the multicenter, random... Read More about Does the Effect of a 3-Year Lifestyle Intervention on Body Weight and Cardiometabolic Health Differ by Prediabetes Metabolic Phenotype? A Post Hoc Analysis of the PREVIEW Study.

Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes: results from the diabetes prevention study PREVIEW (2022)
Journal Article
Zhu, R., Craciun, I., Bernhards-Werge, J., Jalo, E., Poppitt, S. D., Silvestre, M. P., Huttunen-Lenz, M., McNarry, M. A., Stratton, G., Handjiev, S., Handjieva-Darlenska, T., Navas-Carretero, S., Sundvall, J., Adam, T. C., Drummen, M., Simpson, E. J., Macdonald, I. A., Brand-Miller, J., Muirhead, R., Lam, T., …Raben, A. (2022). Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes: results from the diabetes prevention study PREVIEW. Diabetologia, 65(8), 1262-1277. https://doi.org/10.1007/s00125-022-05716-3

Aims/hypothesis

Lifestyle interventions are the first-line treatment option for body weight and cardiometabolic health management. However, whether age groups or women and men respond differently to lifestyle interventions is under debate. We aime... Read More about Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes: results from the diabetes prevention study PREVIEW.

Energy Intake of Men With Excess Weight During Normobaric Hypoxic Confinement (2022)
Journal Article
Mekjavic, I. B., Amon, M., Simpson, E. J., Kölegård, R., Eiken, O., & Macdonald, I. A. (2022). Energy Intake of Men With Excess Weight During Normobaric Hypoxic Confinement. Frontiers in Physiology, 12, Article 801833. https://doi.org/10.3389/fphys.2021.801833

Due to the observations of weight loss at high altitude, normobaric hypoxia has been considered as a method of weight loss in obese individuals. With this regard, the aim of the present study was to determine the effect of hypoxia per se on metabolis... Read More about Energy Intake of Men With Excess Weight During Normobaric Hypoxic Confinement.

Associations of quantity and quality of carbohydrate sources with subjective appetite sensations during 3-year weight-loss maintenance: Results from the PREVIEW intervention study (2021)
Journal Article
Zhu, R., Larsen, T. M., Poppitt, S. D., Silvestre, M. P., Fogelholm, M., Jalo, E., Hätönen, K. A., Huttunen-Lenz, M., Taylor, M. A., Simpson, L., Mackintosh, K. A., McNarry, M. A., Navas-Carretero, S., Martinez, J. A., Handjieva-Darlenska, T., Handjiev, S., Drummen, M., Westerterp-Plantenga, M. S., Lam, T., Vestentoft, P. S., …Raben, A. (2022). Associations of quantity and quality of carbohydrate sources with subjective appetite sensations during 3-year weight-loss maintenance: Results from the PREVIEW intervention study. Clinical Nutrition, 41(1), 219-230. https://doi.org/10.1016/j.clnu.2021.11.038

Background & aims
The association of quantity and quality of carbohydrate sources with appetite during long-term weight-loss maintenance (WLM) after intentional weight loss (WL) is unclear. We aimed to investigate longitudinal associations of quanti... Read More about Associations of quantity and quality of carbohydrate sources with subjective appetite sensations during 3-year weight-loss maintenance: Results from the PREVIEW intervention study.

What Is the Profile of Overweight Individuals Who Are Unsuccessful Responders to a Low-Energy Diet? A PREVIEW Sub-study (2021)
Journal Article
Tremblay, A., Fogelholm, M., Jalo, E., Westerterp-Plantenga, M. S., Adam, T. C., Huttunen-Lenz, M., Stratton, G., Lam, T., Handjieva-Darlenska, T., Handjiev, S., Martinez, J. A., Macdonald, I. A., Simpson, E. J., Brand-Miller, J., Muirhead, R., Poppitt, S. D., Silvestre, M. P., Larsen, T. M., Vestentoft, P. S., Schlicht, W., …Raben, A. (2021). What Is the Profile of Overweight Individuals Who Are Unsuccessful Responders to a Low-Energy Diet? A PREVIEW Sub-study. Frontiers in Nutrition, 8, Article 707682. https://doi.org/10.3389/fnut.2021.707682

This study was performed to evaluate the profile of overweight individuals with pre-diabetes enrolled in PREVIEW who were unable to achieve a body weight loss of ≥8% of the baseline value in response to a 2-month low-energy diet (LED). Their baseline... Read More about What Is the Profile of Overweight Individuals Who Are Unsuccessful Responders to a Low-Energy Diet? A PREVIEW Sub-study.

Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention: A Controlled Post-hoc Trial (2021)
Journal Article
Navas-Carretero, S., San-Cristobal, R., Siig Vestentoft, P., Brand-Miller, J. C., Jalo, E., Westerterp-Plantenga, M., Simpson, E. J., Handjieva-Darlenska, T., Stratton, G., Huttunen-Lenz, M., Lam, T., Muirhead, R., Poppitt, S., Pietiläinen, K. H., Adam, T., Taylor, M. A., Handjiev, S., McNarry, M. A., Hansen, S., Brodie, S., …Martinez, J. A. (2021). Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention: A Controlled Post-hoc Trial. Frontiers in Nutrition, 8, Article 733697. https://doi.org/10.3389/fnut.2021.733697

Background: Individuals with pre-diabetes are commonly overweight and benefit from dietary and physical activity strategies aimed at decreasing body weight and hyperglycemia. Early insulin resistance can be estimated via the triglyceride glucose inde... Read More about Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention: A Controlled Post-hoc Trial.

Substantial and Reproducible Individual Variability in Skeletal Muscle Outcomes in the Cross-Over Designed Planica Bed Rest Program (2021)
Journal Article
Fernandez-Gonzalo, R., McDonnell, A. C., Simpson, E. J., Macdonald, I. A., Rullman, E., & Mekjavic, I. B. (2021). Substantial and Reproducible Individual Variability in Skeletal Muscle Outcomes in the Cross-Over Designed Planica Bed Rest Program. Frontiers in Physiology, 12, Article 676501. https://doi.org/10.3389/fphys.2021.676501

To evaluate the individual responses in skeletal muscle outcomes following bed rest, data from three studies (21-day PlanHab; 10-day FemHab and LunHab) were combined. Subjects (n = 35) participated in three cross-over campaigns within each study: nor... Read More about Substantial and Reproducible Individual Variability in Skeletal Muscle Outcomes in the Cross-Over Designed Planica Bed Rest Program.

The PREVIEW intervention study: Results from a 3-year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes (2020)
Journal Article
Raben, A., Vestentoft, P. S., Brand‐Miller, J., Jalo, E., Drummen, M., Simpson, L., Martinez, J. A., Handjieva‐Darlenska, T., Stratton, G., Huttunen‐Lenz, M., Lam, T., Sundvall, J., Muirhead, R., Poppitt, S., Ritz, C., Pietiläinen, K. H., Westerterp‐Plantenga, M., Taylor, M. A., Carretero, S. N., Handjiev, S., …Fogelholm, M. (2021). The PREVIEW intervention study: Results from a 3-year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes. Diabetes, Obesity and Metabolism, 23(2), 324-337. https://doi.org/10.1111/dom.14219

© 2020 John Wiley & Sons Ltd Aim: To compare the impact of two long-term weight-maintenance diets, a high protein (HP) and low glycaemic index (GI) diet versus a moderate protein (MP) and moderate GI diet, combined with either high intensity (HI) o... Read More about The PREVIEW intervention study: Results from a 3-year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes.

Antecubital Vein Cannula Position Impacts Assessment of Forearm Glucose Uptake During an Oral Glucose Challenge in Healthy Volunteers (2020)
Journal Article
Bétry, C., Nixon, A. V., Greenhaff, P. L., & Simpson, E. J. (2022). Antecubital Vein Cannula Position Impacts Assessment of Forearm Glucose Uptake During an Oral Glucose Challenge in Healthy Volunteers. Experimental and Clinical Endocrinology and Diabetes, 130(01), 49-54. https://doi.org/10.1055/a-1275-4038

© 2020 Lippincott Williams and Wilkins. All rights reserved. Introduction Skeletal muscle is a major site for whole-body glucose disposal, and determination of skeletal muscle glucose uptake is an important metabolic measurement, particularly in rese... Read More about Antecubital Vein Cannula Position Impacts Assessment of Forearm Glucose Uptake During an Oral Glucose Challenge in Healthy Volunteers.

Goal achievement and adaptive goal adjustment in a behavioral intervention for participants with prediabetes (2020)
Journal Article
Huttunen-Lenz, M., Hansen, S., Vestentoft, P. S., Meinert Larsen, T., Westerterp-Plantenga, M., Drummen, M., Adam, T., Macdonald, I., Taylor, M., Simpson, E., Martinez, J. A., Navas-Carretero, S., Handjieva-Darlenska, T., Poppitt, S. D., Silvestre, M. P., Fogelholm, M., Jalo, E., Muirhead, R., Brodie, S., Brand-Miller, J., …Schlicht, W. (2021). Goal achievement and adaptive goal adjustment in a behavioral intervention for participants with prediabetes. Journal of Health Psychology, 26(14), 2743-2755. https://doi.org/10.1177/1359105320925150

© The Author(s) 2020. Participants with prediabetes were supported to achieve and maintain weight loss with a stage-based behavior change group program named PREview behavior Modification Intervention Toolbox (PREMIT). The tendency to engage in a pro... Read More about Goal achievement and adaptive goal adjustment in a behavioral intervention for participants with prediabetes.

The impact of reduced red and processed meat consumption on cardiovascular risk factors; an intervention trial in healthy volunteers (2019)
Journal Article
Simpson, E. J., Clark, M., Razak, A. A., & Salter, A. (2019). The impact of reduced red and processed meat consumption on cardiovascular risk factors; an intervention trial in healthy volunteers. Food and Function, 2019(10), 6690-6698. https://doi.org/10.1039/C9FO00758J

Meat represents an important part of the diet for many adults, supplying essential amino acids and micronutrients. However, high red and processed meat (RPM) intake is implicated in the development of cardiovascular disease and dyslipidemia. This stu... Read More about The impact of reduced red and processed meat consumption on cardiovascular risk factors; an intervention trial in healthy volunteers.

Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease (2018)
Journal Article
Sargeant, J. A., Bawden, S., Aithal, G. P., Simpson, E. J., Macdonald, I. A., Turner, M. C., Cegielski, J., Smith, K., Dorling, J. L., Gowland, P. A., Nimmo, M. A., & King, J. A. (2018). Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease. European Journal of Applied Physiology, 118(4), 817-828. https://doi.org/10.1007/s00421-018-3818-y

Purpose: This study examined the feasibility of sprint interval exercise training (SIT) for men with non-alcoholic fatty liver disease (NAFLD) and its effects on intrahepatic triglyceride (IHTG), insulin sensitivity (hepatic and peripheral), visceral... Read More about Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease.