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The PREVIEW intervention study: Results from a 3-year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes

Raben, Anne; Vestentoft, Pia Siig; Brand?Miller, Jennie; Jalo, Elli; Drummen, Mathjis; Simpson, Liz; Martinez, J. Alfredo; Handjieva?Darlenska, Teodora; Stratton, Gareth; Huttunen?Lenz, Maija; Lam, Tony; Sundvall, Jouko; Muirhead, Roslyn; Poppitt, Sally; Ritz, Christian; Pietil�inen, Kirsi H; Westerterp?Plantenga, Margriet; Taylor, Moira A.; Carretero, Santiago Navas; Handjiev, Svetoslav; McNarry, Melitta A; Hansen, Sylvia; R�man, Laura; Brodie, Shannon; Silvestre, Marta P; Adam, Tanja C; Macdonald, Ian A; San?Cristobal, Rodrigo; Boyadjieva, Nadka; Mackintosh, Kelly A; Schlicht, Wolfgang; Liu, Amy; Larsen, Thomas M; Fogelholm, Mikael

The PREVIEW intervention study: Results from a 3-year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes Thumbnail


Authors

Anne Raben

Pia Siig Vestentoft

Jennie Brand?Miller

Elli Jalo

Mathjis Drummen

Liz Simpson

J. Alfredo Martinez

Teodora Handjieva?Darlenska

Gareth Stratton

Maija Huttunen?Lenz

Tony Lam

Jouko Sundvall

Roslyn Muirhead

Sally Poppitt

Christian Ritz

Kirsi H Pietil�inen

Margriet Westerterp?Plantenga

Santiago Navas Carretero

Svetoslav Handjiev

Melitta A McNarry

Sylvia Hansen

Laura R�man

Shannon Brodie

Marta P Silvestre

Tanja C Adam

Ian A Macdonald

Rodrigo San?Cristobal

Nadka Boyadjieva

Kelly A Mackintosh

Wolfgang Schlicht

Amy Liu

Thomas M Larsen

Mikael Fogelholm



Abstract

© 2020 John Wiley & Sons Ltd Aim: To compare the impact of two long-term weight-maintenance diets, a high protein (HP) and low glycaemic index (GI) diet versus a moderate protein (MP) and moderate GI diet, combined with either high intensity (HI) or moderate intensity physical activity (PA), on the incidence of type 2 diabetes (T2D) after rapid weight loss. Materials and Methods: A 3-year multicentre randomized trial in eight countries using a 2 x 2 diet-by-PA factorial design was conducted. Eight-week weight reduction was followed by a 3-year randomized weight-maintenance phase. In total, 2326 adults (age 25-70 years, body mass index ≥ 25 kg/m2) with prediabetes were enrolled. The primary endpoint was 3-year incidence of T2D analysed by diet treatment. Secondary outcomes included glucose, insulin, HbA1c and body weight. Results: The total number of T2D cases was 62 and the cumulative incidence rate was 3.1%, with no significant differences between the two diets, PA or their combination. T2D incidence was similar across intervention centres, irrespective of attrition. Significantly fewer participants achieved normoglycaemia in the HP compared with the MP group (P

Citation

Raben, A., Vestentoft, P. S., Brand‐Miller, J., Jalo, E., Drummen, M., Simpson, L., Martinez, J. A., Handjieva‐Darlenska, T., Stratton, G., Huttunen‐Lenz, M., Lam, T., Sundvall, J., Muirhead, R., Poppitt, S., Ritz, C., Pietiläinen, K. H., Westerterp‐Plantenga, M., Taylor, M. A., Carretero, S. N., Handjiev, S., …Fogelholm, M. (2021). The PREVIEW intervention study: Results from a 3-year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes. Diabetes, Obesity and Metabolism, 23(2), 324-337. https://doi.org/10.1111/dom.14219

Journal Article Type Article
Acceptance Date Oct 2, 2020
Online Publication Date Nov 3, 2020
Publication Date Feb 1, 2021
Deposit Date Oct 13, 2020
Publicly Available Date Nov 4, 2021
Journal Diabetes, Obesity and Metabolism
Print ISSN 1462-8902
Electronic ISSN 1463-1326
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 23
Issue 2
Pages 324-337
DOI https://doi.org/10.1111/dom.14219
Keywords Internal Medicine; Endocrinology, Diabetes and Metabolism; Endocrinology
Public URL https://nottingham-repository.worktribe.com/output/4962130
Publisher URL https://dom-pubs.onlinelibrary.wiley.com/doi/epdf/10.1111/dom.14219