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Systematic review of the evidence sources applied to cost-effectiveness analyses for older women with primary breast cancer (2022)
Journal Article
Wang, Y., Gavan, S. P., Steinke, D., Cheung, K. L., & Chen, L. C. (2022). Systematic review of the evidence sources applied to cost-effectiveness analyses for older women with primary breast cancer. Cost Effectiveness and Resource Allocation, 20(1), Article 9. https://doi.org/10.1186/s12962-022-00342-7

Objective: To appraise the sources of evidence and methods to estimate input parameter values in decision-analytic model-based cost-effectiveness analyses of treatments for primary breast cancer (PBC) in older patients (≥70years old). Methods: Two el... Read More about Systematic review of the evidence sources applied to cost-effectiveness analyses for older women with primary breast cancer.

Process evaluation of the Bridging the Age Gap in Breast Cancer decision support intervention cluster randomised trial (2021)
Journal Article
Burton, M., Lifford, K. J., Wyld, L., Armitage, F., Ring, A., Nettleship, A., …Audisio, R. (2021). Process evaluation of the Bridging the Age Gap in Breast Cancer decision support intervention cluster randomised trial. Trials, 22(1), Article 447. https://doi.org/10.1186/s13063-021-05360-z

Background The Bridging the Age Gap in Breast Cancer research programme sought to improve treatment decision-making for older women with breast cancer by developing and testing, in a cluster randomised trial (n = 1339 patients), two decision support... Read More about Process evaluation of the Bridging the Age Gap in Breast Cancer decision support intervention cluster randomised trial.

Observational cohort study in older women with early breast cancer: Use of radiation therapy and impact on health-related quality of life and mortality (2021)
Journal Article
Battisti, N. M. L., Hatton, M. Q., Reed, M. W., Herbert, E., Morgan, J. L., Bradburn, M., …Ring, A. (2021). Observational cohort study in older women with early breast cancer: Use of radiation therapy and impact on health-related quality of life and mortality. Radiotherapy and Oncology, 161, 166-176. https://doi.org/10.1016/j.radonc.2021.06.021

Background: Radiotherapy reduces in-breast recurrence risk in early breast cancer (EBC) in older women. This benefit may be small and should be balanced against treatment effect and holistic patient assessment. This study described treatment patterns... Read More about Observational cohort study in older women with early breast cancer: Use of radiation therapy and impact on health-related quality of life and mortality.

Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG) (2021)
Journal Article
Biganzoli, L., Battisti, N. . M. L., Wildiers, H., McCartney, A., Colloca, G., Kunkler, I. H., …Brain, E. G. (2021). Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG). Lancet Oncology, 22(7), e327-e340. https://doi.org/10.1016/S1470-2045%2820%2930741-5

Breast cancer is increasingly prevalent in older adults and is a substantial part of routine oncology practice. However, management of breast cancer in this population is challenging because the disease is highly heterogeneous and there is insufficie... Read More about Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG).

Bridging The Age Gap: observational cohort study of effects of chemotherapy and trastuzumab on recurrence, survival and quality of life in older women with early breast cancer (2021)
Journal Article
Ring, A., Battisti, N. M. L., Reed, M. W. R., Herbert, E., Morgan, J. L., Bradburn, M., …on behalf of the Age Gap TMG. (2021). Bridging The Age Gap: observational cohort study of effects of chemotherapy and trastuzumab on recurrence, survival and quality of life in older women with early breast cancer. British Journal of Cancer, 125, 209-219. https://doi.org/10.1038/s41416-021-01388-9

Background: Chemotherapy improves outcomes for high risk early breast cancer (EBC) patients but is infrequently offered to older individuals. This study determined if there are fit older patients with high-risk disease who may benefit from chemothera... Read More about Bridging The Age Gap: observational cohort study of effects of chemotherapy and trastuzumab on recurrence, survival and quality of life in older women with early breast cancer.

Cost-Effectiveness Modeling of Surgery Plus Adjuvant Endocrine Therapy Versus Primary Endocrine Therapy Alone in UK Women Aged 70 and Over With Early Breast Cancer (2021)
Journal Article
Holmes, G. R., Ward, S. E., Brennan, A., Bradburn, M., Morgan, J. L., Reed, M. W., …Gath, J. (2021). Cost-Effectiveness Modeling of Surgery Plus Adjuvant Endocrine Therapy Versus Primary Endocrine Therapy Alone in UK Women Aged 70 and Over With Early Breast Cancer. Value in Health, 24(6), 770-779. https://doi.org/10.1016/j.jval.2020.12.016

Objectives: Approximately 20% of UK women aged 70+ with early breast cancer receive primary endocrine therapy (PET) instead of surgery. PET reduces surgical morbidity but with some survival decrement. To complement and utilize a treatment dependent p... Read More about Cost-Effectiveness Modeling of Surgery Plus Adjuvant Endocrine Therapy Versus Primary Endocrine Therapy Alone in UK Women Aged 70 and Over With Early Breast Cancer.

Bridging the age gap in breast cancer: impact of omission of breast cancer surgery in older women with oestrogen receptor-positive early breast cancer on quality-of-life outcomes (2021)
Journal Article
Morgan, J. L., Shrestha, A., Reed, M. W. R., Herbert, E., Bradburn, M., Walters, S. J., …Wyld, L. (2021). Bridging the age gap in breast cancer: impact of omission of breast cancer surgery in older women with oestrogen receptor-positive early breast cancer on quality-of-life outcomes. British Journal of Surgery, 108(3), 315-325. https://doi.org/10.1093/bjs/znaa125

BACKGROUND: Primary endocrine therapy may be an alternative treatment for less fit women with oestrogen receptor (ER)-positive breast cancer. This study compared quality-of-life (QoL) outcomes in older women treated with surgery or primary endocrine... Read More about Bridging the age gap in breast cancer: impact of omission of breast cancer surgery in older women with oestrogen receptor-positive early breast cancer on quality-of-life outcomes.

Bridging the age gap in breast cancer: cluster randomized trial of the effects of two decision support interventions for older women with operable breast cancer on quality of life, survival, decision quality, and treatment choices (2021)
Journal Article
Wyld, L., Reed, M. W. R., Collins, K., Burton, M., Lifford, K., Edwards, A., …Thompson, A. M. (2021). Bridging the age gap in breast cancer: cluster randomized trial of the effects of two decision support interventions for older women with operable breast cancer on quality of life, survival, decision quality, and treatment choices. British Journal of Surgery, 108(5), 499-510. https://doi.org/10.1093/bjs/znab005

Background: Rates of surgery and adjuvant therapy for breast cancer vary widely between breast units. This may contribute to differences in survival. This cluster RCT evaluated the impact of decision support interventions (DESIs) for older women with... Read More about Bridging the age gap in breast cancer: cluster randomized trial of the effects of two decision support interventions for older women with operable breast cancer on quality of life, survival, decision quality, and treatment choices.

Age-related biology of early-stage operable breast cancer and its impact on clinical outcome (2021)
Journal Article
Cheung, K. L., Ellis, I. O., Morgan, D. A., Rakha, E. A., Green, A. R., & Syed, B. M. (2021). Age-related biology of early-stage operable breast cancer and its impact on clinical outcome. Cancers, 13(6), Article 1417. https://doi.org/10.3390/cancers13061417

As age advances, breast cancer (BC) tends to change its biological characteristics. This study aimed to explore the natural progression of such changes. The study included 2383 women with clinically T0-2N0-1M0 BC, managed by primary surgery and optim... Read More about Age-related biology of early-stage operable breast cancer and its impact on clinical outcome.

Treatment choices for older women with primary operable breast cancer and cognitive impairment: Results from a prospective, multicentre cohort study (2021)
Journal Article
Martin, C., Shrestha, A., Morgan, J., Bradburn, M., Herbert, E., Burton, M., …Wyld, L. (2021). Treatment choices for older women with primary operable breast cancer and cognitive impairment: Results from a prospective, multicentre cohort study. Journal of Geriatric Oncology, 12(5), 705-713. https://doi.org/10.1016/j.jgo.2020.12.006

© 2020 The Authors Objectives: The presence of dementia co-existing with a diagnosis of breast cancer may render management more challenging and have a substantial impact on oncological outcomes. The aim of this study was to examine the treatment and... Read More about Treatment choices for older women with primary operable breast cancer and cognitive impairment: Results from a prospective, multicentre cohort study.

Priorities for the global advancement of care for older adults with cancer: an update of the International Society of Geriatric Oncology Priorities Initiative (2020)
Journal Article
Extermann, M., Brain, . E., Canin, B., Cherian, . M. N., Cheung, K. L., de Glas, N., …Wildiers, . H. (2021). Priorities for the global advancement of care for older adults with cancer: an update of the International Society of Geriatric Oncology Priorities Initiative. Lancet Oncology, 22(1), e29-e36. https://doi.org/10.1016/S1470-2045%2820%2930473-3

In 2011, the International Society of Geriatric Oncology (SIOG) published the SIOG 10 Priorities Initiative, which defined top priorities for the improvement of the care of older adults with cancer worldwide.1 Substantial scientific, clinical, and ed... Read More about Priorities for the global advancement of care for older adults with cancer: an update of the International Society of Geriatric Oncology Priorities Initiative.

Bridging the Age Gap in breast cancer: Impact of chemotherapy on quality of life in older women with early breast cancer (2020)
Journal Article
Battisti, N. M. L., Reed, M. W., Herbert, E., Morgan, J. L., Collins, K. A., Ward, S. E., …Ring, A. (2021). Bridging the Age Gap in breast cancer: Impact of chemotherapy on quality of life in older women with early breast cancer. European Journal of Cancer, 144, 269-280. https://doi.org/10.1016/j.ejca.2020.11.022

Introduction: Older patients with early breast cancer (EBC) derive modest survival benefit from chemotherapy but have increased toxicity risk. Data on the impact of chemotherapy for EBC on quality of life in older patients are limited, but this is a... Read More about Bridging the Age Gap in breast cancer: Impact of chemotherapy on quality of life in older women with early breast cancer.

Patterns of biomarker expression in patients treated with primary endocrine therapy – a unique insight using core needle biopsy tissue microarray (2020)
Journal Article
Parks, R. M., Albanghali, M. A., Syed, B. M., Green, A. R., Ellis, I. O., & Cheung, K. L. (2021). Patterns of biomarker expression in patients treated with primary endocrine therapy – a unique insight using core needle biopsy tissue microarray. Breast Cancer Research and Treatment, 185(3), 647-655. https://doi.org/10.1007/s10549-020-06023-4

© 2020, The Author(s). Purpose: Prediction of response to primary endocrine therapy (PET) in older women is based on measurement of oestrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor (HER)-2. This study uses a uniq... Read More about Patterns of biomarker expression in patients treated with primary endocrine therapy – a unique insight using core needle biopsy tissue microarray.

Bridging the age gap in breast cancer. Impacts of omission of breast cancer surgery in older women with oestrogen receptor positive early breast cancer. A risk stratified analysis of survival outcomes and quality of life (2020)
Journal Article
Wyld, L., Reed, M. W., Morgan, J., Collins, K., Ward, S., Holmes, G. R., …Thomson, A. M. (2021). Bridging the age gap in breast cancer. Impacts of omission of breast cancer surgery in older women with oestrogen receptor positive early breast cancer. A risk stratified analysis of survival outcomes and quality of life. European Journal of Cancer, 142, 48-62. https://doi.org/10.1016/j.ejca.2020.10.015

Background: Age-related breast cancer treatment variance is widespread with many older women having primary endocrine therapy (PET), which may contribute to inferior survival and local control. This propensity-matched study determined if a subgroup o... Read More about Bridging the age gap in breast cancer. Impacts of omission of breast cancer surgery in older women with oestrogen receptor positive early breast cancer. A risk stratified analysis of survival outcomes and quality of life.

The predictive value of G8 and the Cancer and aging research group chemotherapy toxicity tool in treatment-related toxicity in older Chinese patients with cancer (2020)
Journal Article
Chan, W. L., Ma, T., Cheung, K. L., Choi, H., Wong, J., Lam, K. O., …Kwong, D. (2021). The predictive value of G8 and the Cancer and aging research group chemotherapy toxicity tool in treatment-related toxicity in older Chinese patients with cancer. Journal of Geriatric Oncology, 12(4), 557-562. https://doi.org/10.1016/j.jgo.2020.10.013

Introduction: Older patients experience a higher risk of treatment-related toxicity (TRT). The G8 screening tool was developed to separate cancer older patients fit to receive standard treatment from those who are frail and experiencing functional de... Read More about The predictive value of G8 and the Cancer and aging research group chemotherapy toxicity tool in treatment-related toxicity in older Chinese patients with cancer.

Age specific recruitment and retention to a large multicentre observational breast cancer trial in older women: The Age Gap Trial (2020)
Journal Article
Todd, A., Martin, C., Morgan, J., Herbert, E., Bradburn, M., Burton, M., …Wyld, L. (2021). Age specific recruitment and retention to a large multicentre observational breast cancer trial in older women: The Age Gap Trial. Journal of Geriatric Oncology, 12(5), 714-723. https://doi.org/10.1016/j.jgo.2020.10.015

Introduction Recruitment and retention are two of the most important factors in successfully running clinical trials. Many trials encounter problems with both, causing delays or preventing study progress. These issues are greater in older adults and... Read More about Age specific recruitment and retention to a large multicentre observational breast cancer trial in older women: The Age Gap Trial.

Observational cohort study to determine the degree and causes of variation in the rate of surgery or primary endocrine therapy in older women with operable breast cancer (2020)
Journal Article
Morgan, J. L., Holmes, G., Ward, S., Martin, C., Burton, M., Walters, S. J., …Parmeshwar, R. (2021). Observational cohort study to determine the degree and causes of variation in the rate of surgery or primary endocrine therapy in older women with operable breast cancer. EJSO - European Journal of Surgical Oncology, 47(2), 261-268. https://doi.org/10.1016/j.ejso.2020.09.029

© 2020 The Authors Background: In the UK there is variation in the treatment of older women with breast cancer, with up to 40% receiving primary endocrine therapy (PET), which is associated with inferior survival. Case mix and patient choice may expl... Read More about Observational cohort study to determine the degree and causes of variation in the rate of surgery or primary endocrine therapy in older women with operable breast cancer.

Clinical relevance of biomarkers in oestrogen receptor positive breast cancer (2020)
Book Chapter
Parks, R. M., & Cheung, K. L. (2020). Clinical relevance of biomarkers in oestrogen receptor positive breast cancer. In G. G. Chen, M. C. Tong, & C. van Hasselt (Eds.), Estrogen receptors: structure, functions and clinical aspects (53-91). Nova Science Publishers

© 2020 Nova Science Publishers, Inc. Some biomarkers have been examined extensively in the context of breast cancer, including the oestrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2). They are now routinely measured and used c... Read More about Clinical relevance of biomarkers in oestrogen receptor positive breast cancer.