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Management and outcomes for older women with early breast cancer treated with primary endocrine therapy (PET) (2024)
Journal Article
Hubbard, T., Wright, G., Morgan, J., Martin, C., Walters, S., Cheung, K.-L., Audisio, R., Reed, M., & Wyld, L. (2024). Management and outcomes for older women with early breast cancer treated with primary endocrine therapy (PET). Breast, 77, Article 103768. https://doi.org/10.1016/j.breast.2024.103768

Background: This study reports the detailed management and outcomes of women treated with Primary Endocrine Therapy (PET) in a large prospective UK cohort of older women (≥70) with breast cancer. Methods: This was an unplanned secondary analysis of a... Read More about Management and outcomes for older women with early breast cancer treated with primary endocrine therapy (PET).

Leave no one behind: A global survey of the current state of geriatric oncology practice by SIOG national representatives (2024)
Journal Article
Mizutani, T., Cheung, K.-L., Hakobyan, Y., Lane, H., Decoster, L., Karnakis, T., Puts, M., Calderon, O., Jørgensen, T. L., Boulahssass, R., Wedding, U., Karampeazis, A., Chan, W. W. L., Banerjee, J., Falci, C., van Leeuwen, B. L., Fonseca, V., Gironés Sarrió, R., Vetter, M., Dougoud, V., …Kanesvaran, R. (2024). Leave no one behind: A global survey of the current state of geriatric oncology practice by SIOG national representatives. Journal of Geriatric Oncology, 15(2), Article 10179. https://doi.org/10.1016/j.jgo.2024.101709

Introduction
The Sustainable Development Goals of the United Nations include a commitment to “leave no one behind” as a universal goal. To achieve this in geriatric oncology (GO) worldwide, it is important to understand the current state of GO at an... Read More about Leave no one behind: A global survey of the current state of geriatric oncology practice by SIOG national representatives.

Survival Outcomes in Older Women with Oestrogen-Receptor-Positive Early-Stage Breast Cancer: Primary Endocrine Therapy vs. Surgery by Comorbidity and Frailty Levels (2024)
Journal Article
Wang, Y., Steinke, D., Gavan, S. P., Chen, T.-C., Carr, M. J., Ashcroft, D. M., …Chen, L.-C. (2024). Survival Outcomes in Older Women with Oestrogen-Receptor-Positive Early-Stage Breast Cancer: Primary Endocrine Therapy vs. Surgery by Comorbidity and Frailty Levels. Cancers, 16(4), Article 749. https://doi.org/10.3390/cancers16040749

Primary endocrine therapy (PET) offers non-surgical treatment for older women with early-stage breast cancer who are unsuitable for surgery due to frailty or comorbidity. This research assessed all-cause and breast cancer-specific mortality of PET vs... Read More about Survival Outcomes in Older Women with Oestrogen-Receptor-Positive Early-Stage Breast Cancer: Primary Endocrine Therapy vs. Surgery by Comorbidity and Frailty Levels.

Treatment and outcomes in breast cancer patients: A cross section study from the EUSOMA breast centre network (2023)
Journal Article
Aristei, C., Tomatis, M., Ponti, A., Marotti, L., Cardoso, M. J., Cheung, K. L., …Rubio, I. T. (2024). Treatment and outcomes in breast cancer patients: A cross section study from the EUSOMA breast centre network. European Journal of Cancer, 196, Article 113438. https://doi.org/10.1016/j.ejca.2023.113438

Introduction
The present study was designed to describe tumour features and treatments for patients with breast cancer. It also aimed at assessing the risk of distant metastases in relation to biological profiles, disease stages and treatment.
Meth... Read More about Treatment and outcomes in breast cancer patients: A cross section study from the EUSOMA breast centre network.

Geriatric Oncology as an Unmet Workforce Training Need in the United Kingdom—A Narrative Review by the British Oncology Network for Undergraduate Societies (BONUS) and the International Society of Geriatric Oncology (SIOG) UK Country Group (2023)
Journal Article
Khoury, E. G., Nuamek, T., Heritage, S., Fulton-Ward, T., Kucharczak, J., Ng, C., …Baxter, M. A. (2023). Geriatric Oncology as an Unmet Workforce Training Need in the United Kingdom—A Narrative Review by the British Oncology Network for Undergraduate Societies (BONUS) and the International Society of Geriatric Oncology (SIOG) UK Country Group. Cancers, 15(19), 4782. https://doi.org/10.3390/cancers15194782

Cancer is a disease associated with ageing. Managing cancer in older adults may prove challenging owing to pre-existing frailty, comorbidity, and wider holistic needs, as well as the unclear benefits and harms of standard treatment options. With the... Read More about Geriatric Oncology as an Unmet Workforce Training Need in the United Kingdom—A Narrative Review by the British Oncology Network for Undergraduate Societies (BONUS) and the International Society of Geriatric Oncology (SIOG) UK Country Group.

Assessing patient-reported outcomes (PROs) and patient-related outcomes in randomized cancer clinical trials for older adults: Results of DATECAN-ELDERLY initiative (2023)
Journal Article
Galvin, A., Soubeyran, P., Brain, E., Cheung, K. L., Hamaker, M. E., Kanesvaran, R., …Bellera, C. (2023). Assessing patient-reported outcomes (PROs) and patient-related outcomes in randomized cancer clinical trials for older adults: Results of DATECAN-ELDERLY initiative. Journal of Geriatric Oncology, Article 101611. https://doi.org/10.1016/j.jgo.2023.101611

As older adults with cancer are underrepresented in randomized clinical trials (RCT), there is limited evidence on which to rely for treatment decisions for this population. Commonly used RCT endpoints for the assessment of treatment efficacy are mor... Read More about Assessing patient-reported outcomes (PROs) and patient-related outcomes in randomized cancer clinical trials for older adults: Results of DATECAN-ELDERLY initiative.

Geriatric assessment for older people with cancer: policy recommendations (2023)
Journal Article
Seghers, P. A., Alibhai, S. M., Battisti, N. M. L., Kanesvaran, R., Extermann, M., O’Donovan, A., …O’Hanlon, S. (2023). Geriatric assessment for older people with cancer: policy recommendations. Global Health Research and Policy, 8(1), Article 37. https://doi.org/10.1186/s41256-023-00323-0

Most cancers occur in older people and the burden in this age group is increasing. Over the past two decades the evidence on how best to treat this population has increased rapidly. However, implementation of new best practices has been slow and need... Read More about Geriatric assessment for older people with cancer: policy recommendations.

Oncoplastic breast surgery in older women with primary breast cancer: a systematic review (2023)
Journal Article
Chia, Z., Lee, R. X. N., Cardoso, M. J., Cheung, K. L., & Parks, R. M. (2023). Oncoplastic breast surgery in older women with primary breast cancer: a systematic review. British Journal of Surgery, 110(10), 1309-1315. https://doi.org/10.1093/bjs/znad161

Oncoplastic procedures allow excision of larger breast tumours, or unfavourable tumour/breast ratio lesions while achieving a good cosmetic outcome. This increases the pool of patients eligible for breast conservation over mastectomy, reducing the ne... Read More about Oncoplastic breast surgery in older women with primary breast cancer: a systematic review.

Assessment of the Androgen Receptor in Older Women with Primary Breast Cancer: Association with a Panel of Biomarkers and Breast Cancer Specific Survival (2023)
Journal Article
Kalvala, J., Parks, R. M., Abdi, J., Green, A. R., & Cheung, K. L. (2023). Assessment of the Androgen Receptor in Older Women with Primary Breast Cancer: Association with a Panel of Biomarkers and Breast Cancer Specific Survival. Advances in Therapy, https://doi.org/10.1007/s12325-023-02504-2

Introduction
Breast cancer in older women tends to have more favourable biology, compared to younger women. Androgen receptor (AR) is significant for breast tumour carcinogenesis; however, the role of AR in older women has not been fully explored.... Read More about Assessment of the Androgen Receptor in Older Women with Primary Breast Cancer: Association with a Panel of Biomarkers and Breast Cancer Specific Survival.

Improving the Assessment and Diagnosis of Breast Lymphedema after Treatment for Breast Cancer (2023)
Journal Article
Riches, K., Cheung, K. L., & Keeley, V. (2023). Improving the Assessment and Diagnosis of Breast Lymphedema after Treatment for Breast Cancer. Cancers, 15(6), Article 1758. https://doi.org/10.3390/cancers15061758

Lymphedema can develop after treatment for breast cancer (BCRL). Lymphedema of the breast is not well studied. Currently, the main techniques used to diagnose and monitor the effectiveness of treatment are subjective clinician assessment and patient... Read More about Improving the Assessment and Diagnosis of Breast Lymphedema after Treatment for Breast Cancer.

Revisiting primary endocrine therapy versus surgery in older women with breast cancer: meta-analysis (2023)
Journal Article
Chan, K. S., Chong, M. T. H., Chia, C. L. K., & Cheung, K. L. (2023). Revisiting primary endocrine therapy versus surgery in older women with breast cancer: meta-analysis. British Journal of Surgery, 110(4), 420-431. https://doi.org/10.1093/bjs/znac435

Background Old age is associated with increased co-morbidities, resulting in reduced life expectancy. Primary endocrine therapy is an alternative to primary surgical therapy for patients with breast cancer and increased co-morbidities. The aim was to... Read More about Revisiting primary endocrine therapy versus surgery in older women with breast cancer: meta-analysis.

The Association Between Medication Use in Older Women with Early-Stage Operable Primary Breast Cancer and Decision Regarding Primary Treatment (2023)
Journal Article
Tse, N., Parks, R. M., Holmes, H. M., & Cheung, K. L. (2023). The Association Between Medication Use in Older Women with Early-Stage Operable Primary Breast Cancer and Decision Regarding Primary Treatment. Oncologist, 28(3), e128-e135. https://doi.org/10.1093/oncolo/oyac278

Background Polypharmacy is one factor contributing to increased mortality, hospitalization, and adverse drug reactions in older adults. The aim of this study was to measure the prevalence of polypharmacy in a cohort of older women with early-stage op... Read More about The Association Between Medication Use in Older Women with Early-Stage Operable Primary Breast Cancer and Decision Regarding Primary Treatment.

The impact of age on health utility values for older women with early-stage breast cancer: a systematic review and meta-regression (2022)
Journal Article
Wang, Y., Gavan, S. P., Steinke, D., Cheung, K. L., & Chen, L. C. (2022). The impact of age on health utility values for older women with early-stage breast cancer: a systematic review and meta-regression. Health and Quality of Life Outcomes, 20(1), Article 169. https://doi.org/10.1186/s12955-022-02067-w

Introduction: An increasing number of postmenopausal women are diagnosed with breast cancer at an older age (≥ 70years). There is a lack of synthesised health utility data to support decision-making for managing breast cancer in this older population... Read More about The impact of age on health utility values for older women with early-stage breast cancer: a systematic review and meta-regression.

The impact of the SARS-COV-2 pandemic on the quality of breast cancer care in EUSOMA-certified breast centres (2022)
Journal Article
van Dam, P., Tomatis, M., Ponti, A., Marotti, L., Aristei, C., Biganzoli, L., …Verhoeven, D. (2022). The impact of the SARS-COV-2 pandemic on the quality of breast cancer care in EUSOMA-certified breast centres. European Journal of Cancer, 177, 72-79. https://doi.org/10.1016/j.ejca.2022.09.027

Aims: We analysed the impact of the SARS-CoV-2 pandemic (COVID-19) on the quality of breast cancer care in certified EUSOMA (European Society of Breast Cancer Specialists) breast centres. Materials and methods: The results of the EUSOMA quality indic... Read More about The impact of the SARS-COV-2 pandemic on the quality of breast cancer care in EUSOMA-certified breast centres.

Immediate breast reconstruction uptake in older women with primary breast cancer: systematic review (2022)
Journal Article
Lee, R. X. N., Cardoso, M. J., Cheung, K. L., & Parks, R. M. (2022). Immediate breast reconstruction uptake in older women with primary breast cancer: systematic review. British Journal of Surgery, 109(11), 1063-1072. https://doi.org/10.1093/bjs/znac251

BACKGROUND: Postmastectomy immediate breast reconstruction (PMIBR) may improve the quality of life of patients with breast cancer, of whom older women (aged 65 years or more) are a growing proportion. This study aimed to assess PMIBR in older women w... Read More about Immediate breast reconstruction uptake in older women with primary breast cancer: systematic review.

Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT (2022)
Journal Article
Wyld, L., Reed, M. W., Collins, K., Ward, S., Holmes, G., Morgan, J., …Parmeshwar, R. (2022). Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT. Programme Grants for Applied Research, 10(6), 1-114. https://doi.org/10.3310/xzoe2552

Background: In breast cancer management, age-related practice variation is widespread, with older women having lower rates of surgery and chemotherapy than younger women, based on the premise of reduced treatment tolerance and benefit. This may contr... Read More about Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT.

Chemotherapy and gene expression profiling in older early luminal breast cancer patients: An International Society of Geriatric Oncology systematic review (2022)
Journal Article
Battisti, N. M. L., De Glas, N., Soto-Perez-de-Celis, E., Liposits, G., Bringuier, M., Walko, C., …Brain, E. (2022). Chemotherapy and gene expression profiling in older early luminal breast cancer patients: An International Society of Geriatric Oncology systematic review. European Journal of Cancer, 172, 158-170. https://doi.org/10.1016/j.ejca.2022.05.039

Background: The benefit of chemotherapy for older patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer (EBC) is a key area of debate. Gene expression profiling (GEP) may identify p... Read More about Chemotherapy and gene expression profiling in older early luminal breast cancer patients: An International Society of Geriatric Oncology systematic review.