Acute cocoa flavanol supplementation improves muscle macro- and microvascular but not anabolic responses to amino acids in older men

Phillips, Bethan E.; Atherton, Philip J.; Varadhan, Krishna; Limb, Marie C.; Williams, John P.; Smith, Kenneth

doi:10.1139/apnm-2015-0543

All Outputs (6)

Stable isotope tracers and exercise physiology: past, present and future (2016)
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Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein Synthesis, Breakdown, and Insulin Resistance—A Qualitative Review (2016)
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The ever increasing burden of an ageing population and pandemic of metabolic syndrome worldwide demands further understanding of the modifiable risk factors in reducing disability and morbidity associated with these conditions. Disuse skeletal muscle... Read More about Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein Synthesis, Breakdown, and Insulin Resistance—A Qualitative Review.

Metformin Increases Cortisol Regeneration by 11?HSD1 in Obese Men With and Without Type 2 Diabetes Mellitus (2016)
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CONTEXT: The mechanism of action of metformin remains unclear. Given the regulation of the cortisol-regenerating enzyme 11?hydroxysteroid dehydrogenase 1 (11?HSD1) by insulin and the limited efficacy of selective 11?HSD1 inhibitors to lower blood gl... Read More about Metformin Increases Cortisol Regeneration by 11?HSD1 in Obese Men With and Without Type 2 Diabetes Mellitus.

Human Skeletal Muscle Protein Metabolism Responses to Amino Acid Nutrition (2016)
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Healthy individuals maintain remarkably constant skeletal muscle mass across much of adult life, suggesting the existence of robust homeostatic mechanisms. Muscle exists in dynamic equilibrium whereby the influx of amino acids (AAs) and the resulting... Read More about Human Skeletal Muscle Protein Metabolism Responses to Amino Acid Nutrition.

An overview of technical considerations for Western blotting applications to physiological research (2016)
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The applications of Western/immuno-blotting (WB) techniques have reached multiple layers of the scientific community and are now considered routine procedures in the field of physiology. This is none more so than in relation to skeletal muscle physio... Read More about An overview of technical considerations for Western blotting applications to physiological research.

Acute cocoa flavanol supplementation improves muscle macro- and microvascular but not anabolic responses to amino acids in older men (2016)
Journal Article

The anabolic effects of nutrition on skeletal muscle may depend on adequate skeletal muscle perfusion, which is impaired in older people. Cocoa flavanols have been shown to improve flow-mediated dilation, an established measure of endothelial functio... Read More about Acute cocoa flavanol supplementation improves muscle macro- and microvascular but not anabolic responses to amino acids in older men.