Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile

van Eijk, Erika; Paschalis, Vasileios; Green, Matthew; Friggen, Annemieke H.; Larson, Marilynn A.; Spriggs, Keith; Briggs, Geoffrey S.; Soultanas, Panos; Smits, Wiep Klass

doi:10.1098/rsob.160272

All Outputs (2)

Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells (2017)
Journal Article

Polymer micelles have emerged as promising carriers for controlled release applications, however, several limitations of micelle-based drug delivery have also been reported. To address these issues, we have synthesized a functional biodegradable and... Read More about Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells.

Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile (2016)
Journal Article

DNA replication is an essential and conserved process in all domains of life and may serve as a target for the development of new antimicrobials. However, such developments are hindered by subtle mechanistic differences and limited understanding of D... Read More about Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile.