A clinical evaluation of the pharmacokinetics and pharmacodynamics of intravenous alfaxalone in cyclodextrin in male and female rats following a loading dose and constant rate infusion

White, Kate L.; Paine, Stuart; Harris, John

doi:10.1016/j.vaa.2017.01.001

All Outputs (4)

A retrospective review of western lowland gorilla (gorilla, gorilla, gorilla) mortality in European zoological collections between 2004 and 2014 (2017)
Journal Article

An understanding of the main causes of mortality among captive gorillas is imperative to promoting their optimal care, health, and welfare. A retrospective observational review of mortality among the European zoo–housed western lowland gorilla (Goril... Read More about A retrospective review of western lowland gorilla (gorilla, gorilla, gorilla) mortality in European zoological collections between 2004 and 2014.

Safety culture: the Nottingham Veterinary Safety Culture Survey (NVSCS) (2017)
Journal Article

Safety culture is a vital concept in human healthcare because of its influence on staff behaviours in relation to patient safety. Understanding safety culture is essential to ensure the acceptance and sustainability of changes, such as the introducti... Read More about Safety culture: the Nottingham Veterinary Safety Culture Survey (NVSCS).

Clinical comparison of alfaxalone, ketamine and propofol following medetomidine and methadone in dogs (2017)
Journal Article

Objective To compare the clinical effects of alfaxalone, ketamine and propofol in dogs following premedication with medetomidine and methadone. Study design Prospective, ‘blinded’ and randomized clinical study. Animals A total of 75 ma... Read More about Clinical comparison of alfaxalone, ketamine and propofol following medetomidine and methadone in dogs.

A clinical evaluation of the pharmacokinetics and pharmacodynamics of intravenous alfaxalone in cyclodextrin in male and female rats following a loading dose and constant rate infusion (2017)
Journal Article

Objective: To characterise, as a clinical study, the pharmacokinetics and pharmacodynamics and describe the hypnotic effect of the neurosteroid alfaxalone (3?-hydroxy-5 ?-pregnane-11, 20-dione) formulated with 2-hydroxypropyl-?-cyclodextrin in male a... Read More about A clinical evaluation of the pharmacokinetics and pharmacodynamics of intravenous alfaxalone in cyclodextrin in male and female rats following a loading dose and constant rate infusion.