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All Outputs (43)

Methodologies for network meta-analysis of randomised controlled trials in pain, anaesthesia, and perioperative medicine: a narrative review (2025)
Journal Article
Doleman, B., Jakobsen, J. C., Mathiesen, O., Cooper, N., Sutton, A., & Hardman, J. (2025). Methodologies for network meta-analysis of randomised controlled trials in pain, anaesthesia, and perioperative medicine: a narrative review. British Journal of Anaesthesia, 134(4), 1029-1040. https://doi.org/10.1016/j.bja.2024.12.039

Network meta-analysis has emerged as a method for analysing clinical trials, with a large increase in the number of publications over the past decade. Network meta-analysis offers advantages over traditional pairwise meta-analysis, including increase... Read More about Methodologies for network meta-analysis of randomised controlled trials in pain, anaesthesia, and perioperative medicine: a narrative review.

Acute management of adults following chest wall injury: An assessment of institutional clinical practice guidelines across the UK and synthesis of care recommendations (2024)
Journal Article
Chen, C., Sehgal, A., Battle, C., Hardman, J., Ollivere, B., & Hewson, D. W. (2025). Acute management of adults following chest wall injury: An assessment of institutional clinical practice guidelines across the UK and synthesis of care recommendations. Injury, 56(5), Article 112077. https://doi.org/10.1016/j.injury.2024.112077

Objective
Chest wall injury causes significant morbidity and mortality. There is uncertainty regarding many aspects of clinical care for these patients, including optimal analgesia, acuity of monitoring and surgical fixation. Our aim in this work is... Read More about Acute management of adults following chest wall injury: An assessment of institutional clinical practice guidelines across the UK and synthesis of care recommendations.

Impact of spinal or epidural anaesthesia on perioperative outcomes in adult noncardiac surgery: a narrative review of recent evidence (2024)
Journal Article
Hewson, D. W., Tedore, T. R., & Hardman, J. G. (2024). Impact of spinal or epidural anaesthesia on perioperative outcomes in adult noncardiac surgery: a narrative review of recent evidence. British Journal of Anaesthesia, 133(2), 380-399. https://doi.org/10.1016/j.bja.2024.04.044

Spinal and epidural anaesthesia and analgesia are important anaesthetic techniques, familiar to all anaesthetists and applied to patients undergoing a range of surgical procedures. Although the immediate effects of a well-conducted neuraxial techniqu... Read More about Impact of spinal or epidural anaesthesia on perioperative outcomes in adult noncardiac surgery: a narrative review of recent evidence.

Clinical hypnosis: implications in anaesthesia and perioperative care (2023)
Journal Article
Cyna, A. M., Hewson, D. W., & Hardman, J. G. (2023). Clinical hypnosis: implications in anaesthesia and perioperative care. British Journal of Anaesthesia, 130(6), 647-650

A randomised trial published in the British Journal of Anaesthesia describes hypnosis compared with general anaesthesia in 60 children undergoing superficial surgery. We describe a definition of clinical hypnosis; the goals and conduct of hypnotic co... Read More about Clinical hypnosis: implications in anaesthesia and perioperative care.

Evaluating current guidelines for cardiopulmonary resuscitation using an integrated computational model of the cardiopulmonary system (2023)
Journal Article
Daudre-Vignier, C., Bates, D. G., Scott, T. E., Hardman, J. G., & Laviola, M. (2023). Evaluating current guidelines for cardiopulmonary resuscitation using an integrated computational model of the cardiopulmonary system. Resuscitation, 186, Article 109758. https://doi.org/10.1016/j.resuscitation.2023.109758

Objective: We aimed to use a high-fidelity computational model that captures key interactions between the cardiovascular and pulmonary systems to investigate whether current CPR protocols could potentially be improved. Methods: We developed and valid... Read More about Evaluating current guidelines for cardiopulmonary resuscitation using an integrated computational model of the cardiopulmonary system.

Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study (2022)
Journal Article
Ellis, R., Laviola, M., Stolady, D., Valentine, R. L., Pillai, A., & Hardman, J. G. (2022). Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study. British Journal of Anaesthesia, 129(4), 581-587. https://doi.org/10.1016/j.bja.2022.06.021

Background: Hypoxaemia during general anaesthesia can cause harm. Apnoeic oxygenation extends safe apnoea time, reducing risk during airway management. We hypothesised that low-flow nasal oxygenation (LFNO) would extend safe apnoea time similarly to... Read More about Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study.

Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study (2022)
Journal Article
Ellis, R., Laviola, M., Stolady, D., Valentine, R. L., Pillai, A., & Hardman, J. G. (2022). Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study. British Journal of Anaesthesia, 129(4), 581-587. https://doi.org/10.1016/j.bja.2022.06.021

Background
Hypoxaemia during general anaesthesia can cause harm. Apnoeic oxygenation extends safe apnoea time, reducing risk during airway management. We hypothesised that low-flow nasal oxygenation (LFNO) would extend safe apnoea time similarly to... Read More about Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study.

Validation of at-the-bedside formulae for estimating ventilator driving pressure during airway pressure release ventilation using computer simulation (2022)
Journal Article
Mistry, S., Das, A., Saffaran, S., Yehya, N., Scott, T. E., Chikhani, M., Laffey, J. G., Hardman, J. G., Camporota, L., & Bates, D. G. (2022). Validation of at-the-bedside formulae for estimating ventilator driving pressure during airway pressure release ventilation using computer simulation. Respiratory Research, 23, Article 101. https://doi.org/10.1186/s12931-022-01985-z

Background: Airway pressure release ventilation (APRV) is widely available on mechanical ventilators and has been proposed as an early intervention to prevent lung injury or as a rescue therapy in the management of refractory hypoxemia. Driving press... Read More about Validation of at-the-bedside formulae for estimating ventilator driving pressure during airway pressure release ventilation using computer simulation.

Optimising respiratory support for early COVID-19 pneumonia: a computational modelling study (2022)
Journal Article
Weaver, L., Das, A., Saffaran, S., Yehya, N., Chikhani, M., Scott, T. E., Laffey, J. G., Hardman, J. G., Camporota, L., & Bates, D. G. (2022). Optimising respiratory support for early COVID-19 pneumonia: a computational modelling study. British Journal of Anaesthesia, https://doi.org/10.1016/j.bja.2022.02.037

Background: Optimal respiratory support in early COVID-19 pneumonia is controversial and remains unclear. Using computational modelling, we examined whether lung injury might be exacerbated in early COVID-19 by assessing the impact of conventional ox... Read More about Optimising respiratory support for early COVID-19 pneumonia: a computational modelling study.

Patient-maintained versus anaesthetist-controlled propofol sedation during elective primary lower-limb arthroplasty performed under spinal anaesthesia: a randomised controlled trial (2021)
Journal Article
Hewson, D. W., Worcester, F., Sprinks, J., Smith, M. D., Buchanan, H., Breedon, P., Hardman, J. G., & Bedforth, N. M. (2022). Patient-maintained versus anaesthetist-controlled propofol sedation during elective primary lower-limb arthroplasty performed under spinal anaesthesia: a randomised controlled trial. British Journal of Anaesthesia, 128(1), 186-197. https://doi.org/10.1016/j.bja.2021.09.038

Background: Patient-maintained propofol TCI sedation (PMPS) allows patients to titrate their own target-controlled infusion (TCI) delivery of propofol sedation using a handheld button. The aim of this RCT was to compare PMPS with anaesthetist-control... Read More about Patient-maintained versus anaesthetist-controlled propofol sedation during elective primary lower-limb arthroplasty performed under spinal anaesthesia: a randomised controlled trial.

Intra-tracheal multiplexed sensing of contact pressure and perfusion (2021)
Journal Article
Correia, R., Gadsby, B., Korposh, S., Norris, A. M., Hayes-Gill, B. R., Sinha, R., Hardman, J. G., Gardner, D. S., Talbot, S., Harvey, D., McGlashan, J., & Morgan, S. P. (2022). Intra-tracheal multiplexed sensing of contact pressure and perfusion. Biomedical Optics Express, 13(1), 48-64. https://doi.org/10.1364/BOE.442165

Incorrect endotracheal tube (ETT) cuff inflation pressure causes significant problems for intubated patients. The technical development and first in vivo use of a smart ETT for measurements at the cuff-trachea interface during mechanical ventilation... Read More about Intra-tracheal multiplexed sensing of contact pressure and perfusion.

Pre-hospital continuous positive airway pressure after blast lung injury and hypovolaemic shock: a modelling study (2021)
Journal Article
Mistry, S., Das, A., Hardman, J. G., Bates, D. G., & Scott, T. E. (2022). Pre-hospital continuous positive airway pressure after blast lung injury and hypovolaemic shock: a modelling study. British Journal of Anaesthesia, 128(2), e151-e157. https://doi.org/10.1016/j.bja.2021.10.012

Background
In non-traumatic respiratory failure, pre-hospital application of CPAP reduces the need for intubation. Primary blast lung injury (PBLI) accompanied by haemorrhagic shock is common after mass casualty incidents. We hypothesised that pre-h... Read More about Pre-hospital continuous positive airway pressure after blast lung injury and hypovolaemic shock: a modelling study.

High risk of patient self-inflicted lung injury in COVID-19 with frequently encountered spontaneous breathing patterns: a computational modelling study (2021)
Journal Article
Weaver, L., Das, A., Saffaran, S., Yehya, N., Scott, T. E., Chikhani, M., Laffey, J. G., Hardman, J. G., Camporota, L., & Bates, D. G. (2021). High risk of patient self-inflicted lung injury in COVID-19 with frequently encountered spontaneous breathing patterns: a computational modelling study. Annals of Intensive Care, 11(1), Article 109. https://doi.org/10.1186/s13613-021-00904-7

Background: There is ongoing controversy regarding the potential for increased respiratory effort to generate patient self-inflicted lung injury (P-SILI) in spontaneously breathing patients with COVID-19 acute hypoxaemic respiratory failure. However,... Read More about High risk of patient self-inflicted lung injury in COVID-19 with frequently encountered spontaneous breathing patterns: a computational modelling study.

Ventilation strategies for front of neck airway rescue: an in silico study (2021)
Journal Article
Laviola, M., Niklas, C., Das, A., Bates, D. G., & Hardman, J. G. (2021). Ventilation strategies for front of neck airway rescue: an in silico study. British Journal of Anaesthesia, 126(6), 1226-1236. https://doi.org/10.1016/j.bja.2021.01.030

Background. During induction of general anaesthesia a “can’t intubate, can’t oxygenate” (CICO) situation can arise, leading to severe hypoxaemia. Evidence is scarce to guide ventilation strategies for small-bore front of neck airways that ensure effe... Read More about Ventilation strategies for front of neck airway rescue: an in silico study.

Effect of variable pre-oxygenation endpoints on safe apnoea time using high flow nasal oxygen for women in labour: a modelling investigation (2021)
Journal Article
Stolady, D., Laviola, M., Pillai, A., & Hardman, J. G. (2021). Effect of variable pre-oxygenation endpoints on safe apnoea time using high flow nasal oxygen for women in labour: a modelling investigation. British Journal of Anaesthesia, 126(4), 889-895. https://doi.org/10.1016/j.bja.2020.12.031

Background

Studies of pulmonary denitrogenation (pre-oxygenation) in obstetric populations have shown high flow nasal oxygen therapy (HFNO) is inferior to facemask techniques. HFNO achieves median end-tidal oxygen fraction (FE′O2) of 0.87 after 3... Read More about Effect of variable pre-oxygenation endpoints on safe apnoea time using high flow nasal oxygen for women in labour: a modelling investigation.

In Silico Modeling of Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Pathophysiologic Insights and Potential Management Implications (2020)
Journal Article
Das, A., Saffaran, S., Chikhani, M., Scott, T. E., Laviola, M., Yehya, N., Laffey, J. G., Hardman, J. G., & Bates, D. G. (2020). In Silico Modeling of Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Pathophysiologic Insights and Potential Management Implications. Critical Care Explorations, 2(9), Article e0202. https://doi.org/10.1097/CCE.0000000000000202

Objectives: Patients with COVID-19 Acute Respiratory Distress Syndrome (CARDS) appear to present with at least two distinct phenotypes: severe hypoxemia with relatively well-preserved lung compliance and lung gas volumes (Type 1) and a more conventio... Read More about In Silico Modeling of Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Pathophysiologic Insights and Potential Management Implications.

Patient-maintained propofol sedation for adult patients undergoing surgical or medical procedures: a scoping review of current evidence and technology (2020)
Journal Article
Hewson, D. W., Hardman, J. G., & Bedforth, N. M. (2021). Patient-maintained propofol sedation for adult patients undergoing surgical or medical procedures: a scoping review of current evidence and technology. British Journal of Anaesthesia, 126(1), 139-148. https://doi.org/10.1016/j.bja.2020.07.053

Patient-maintained propofol sedation (PMPS) is the delivery of procedural propofol sedation by target-controlled infusion with the patient exerting an element of control over their target-site propofol concentration. This scoping review aims to estab... Read More about Patient-maintained propofol sedation for adult patients undergoing surgical or medical procedures: a scoping review of current evidence and technology.

The impact of video games on ultrasound-guided regional anesthesia skills (2020)
Journal Article
Shafqat, A., Mukarram, S., Bedforth, N. M., Hardman, J. G., & Mccahon, R. A. (2020). The impact of video games on ultrasound-guided regional anesthesia skills. Regional Anesthesia and Pain Medicine, 45(11), 860-865. https://doi.org/10.1136/rapm-2020-101641

Background: There is an association between video game practice and laparoscopic expertise in trainee surgeons. Ultrasound-guided regional anesthesia has many parallels with laparoscopic surgery. The aim of this study was to explore whether video gam... Read More about The impact of video games on ultrasound-guided regional anesthesia skills.