All Outputs (77)

Loss of muscle mass in the immediate post-operative period is associated with inadequate dietary protein and energy intake (2023)
Journal Article
Hardy, E. J., Deane, C. S., Lund, J. N., & Phillips, B. E. (2023). Loss of muscle mass in the immediate post-operative period is associated with inadequate dietary protein and energy intake. European Journal of Clinical Nutrition, 77, 503-505. https://doi.org/10.1038/s41430-023-01264-0

Despite the implementation of ‘Enhanced Recovery After Surgery’ (ERAS) protocols, major abdominal surgery is still associated with significant and detrimental losses of muscle mass and function in the post-operative period. Although ERAS protocols ad... Read More about Loss of muscle mass in the immediate post-operative period is associated with inadequate dietary protein and energy intake.

Differences in progression by surgical specialty: A national cohort study (2022)
Journal Article
Hope, C., Lund, J., Griffiths, G., & Humes, D. (2022). Differences in progression by surgical specialty: A national cohort study. BMJ Open, 12(2), Article e053391. https://doi.org/10.1136/bmjopen-2021-053391

The aim of surgical training across the 10 surgical specialties is to produce competent day 1 consultants. Progression through training in the UK is assessed by the Annual Review of Competency Progression (ARCP). Objective This study aimed to examine... Read More about Differences in progression by surgical specialty: A national cohort study.

Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults (2021)
Journal Article
Din, U. S. U., Sian, T. S., Deane, C. S., Smith, K., Gates, A., Lund, J. N., …Phillips, B. E. (2021). Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults. Nutrients, 13(11), Article 3895. https://doi.org/10.3390/nu13113895

Postprandial macro-and microvascular blood flow and metabolic dysfunction manifest with advancing age, so vascular transmuting interventions are desirable. In this randomised, singleblind, placebo-controlled, crossover trial, we investigated the impa... Read More about Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults.

Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults (2021)
Journal Article
Herrod, P. J., Atherton, P. J., Smith, K., Williams, J. P., Lund, J. N., & Phillips, B. E. (2021). Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults. GeroScience, 43(6), 2667-2678. https://doi.org/10.1007/s11357-021-00463-6

Impairments in muscle microvascular function are associated with the pathogenesis of sarcopenia and cardiovascular disease. High-intensity interval training (HIIT) is an intervention by which a myriad of beneficial skeletal muscle/cardiovascular adap... Read More about Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults.

Contrast‐enhanced ultrasound assessed renal microvascular perfusion may predict postoperative renal complications following colorectal surgery (2021)
Journal Article
Read, D., Doleman, B., Heinink, T., Selby, N., Lund, J., Phillips, B., & Williams, J. (2021). Contrast‐enhanced ultrasound assessed renal microvascular perfusion may predict postoperative renal complications following colorectal surgery. Clinical and Experimental Pharmacology and Physiology, 48(7), 971-977. https://doi.org/10.1111/1440-1681.13501

Colorectal surgery is associated with an above‐average mortality rate of ~15%. During surgery, maintenance of vital organ perfusion is essential in order to reduce postoperative mortality and morbidity, with renal perfusion of particular importance.... Read More about Contrast‐enhanced ultrasound assessed renal microvascular perfusion may predict postoperative renal complications following colorectal surgery.

Factors Associated with Attrition and Performance Throughout Surgical Training: A Systematic Review and Meta-Analysis (2020)
Journal Article
Hope, C., Reilly, J.-J., Griffiths, G., Lund, J., & Humes, D. (2021). Factors Associated with Attrition and Performance Throughout Surgical Training: A Systematic Review and Meta-Analysis. World Journal of Surgery, 45, 429-442

Background Attrition within surgical training is a challenge. In the USA, attrition rates are as high as 20-26%. The factors predicting attrition are not well known. The aim of this systematic review is to identify factors that influence attrition or... Read More about Factors Associated with Attrition and Performance Throughout Surgical Training: A Systematic Review and Meta-Analysis.

Time-efficient physical activity interventions to reduce blood pressure in older adults: a randomized controlled trial (2020)
Journal Article
Herrod, P., Lund, J., & Phillips, B. (2021). Time-efficient physical activity interventions to reduce blood pressure in older adults: a randomized controlled trial. Age and Ageing, 50(3), 980-984. https://doi.org/10.1093/ageing/afaa211

Background
Hypertension is a risk factor for both cardiovascular and cerebrovascular disease, with an increasing incidence with advancing patient age. Exercise interventions have the potential to reduce blood pressure in older adults, however, rates... Read More about Time-efficient physical activity interventions to reduce blood pressure in older adults: a randomized controlled trial.

Fasting and surgery timing (FaST) audit (2020)
Journal Article
El-Sharkawy, A. M., Daliya, P., Lewis-Lloyd, C., Adiamah, A., Malcolm, F. L., Boyd-Carson, H., …Wolff, J. (2021). Fasting and surgery timing (FaST) audit. Clinical Nutrition, 40(3), 1405-1412. https://doi.org/10.1016/j.clnu.2020.08.033

Background & aims

International guidance advocates the avoidance of prolonged preoperative fasting due to its negative impact on perioperative hydration. This study aimed to assess the adherence to these guidelines for fasting in patients undergoi... Read More about Fasting and surgery timing (FaST) audit.

The management of adult appendicitis during the COVID-19 pandemic: an interim analysis of a UK cohort study (2020)
Journal Article
Javanmard-Emamghissi, H., Boyd-Carson, H., Hollyman, M., Doleman, B., Adiamah, A., Lund, J. N., …The COVID: HAREM (Had Appendicitis, Resolved/Recurred Emergency Morbidity/Mortality) Collaborators Group. (2021). The management of adult appendicitis during the COVID-19 pandemic: an interim analysis of a UK cohort study. Techniques in Coloproctology, 25(4), 401–411. https://doi.org/10.1007/s10151-020-02297-4

Background
Acute appendicitis (AA) is the most common general surgical emergency. Early laparoscopic appendicectomy is the gold-standard management. SARS-CoV-2 (COVID-19) brought concerns of increased perioperative mortality and spread of infection... Read More about The management of adult appendicitis during the COVID-19 pandemic: an interim analysis of a UK cohort study.

Funnel plots may show asymmetry in the absence of publication bias with continuous outcomes dependent on baseline risk: presentation of a new publication bias test (2020)
Journal Article
Doleman, B., Freeman, S. C., Lund, J. N., Williams, J. P., & Sutton, A. J. (2020). Funnel plots may show asymmetry in the absence of publication bias with continuous outcomes dependent on baseline risk: presentation of a new publication bias test. Research Synthesis Methods, 11(4), 522-534. https://doi.org/10.1002/jrsm.1414

This study aimed to determine for continuous outcomes dependent on baseline risk, whether funnel plot asymmetry may be due to statistical artefact rather than publication bias and evaluate a novel test to resolve this. Firstly, we conducted assessmen... Read More about Funnel plots may show asymmetry in the absence of publication bias with continuous outcomes dependent on baseline risk: presentation of a new publication bias test.

Trainee-led emergency laparotomy operating (2020)
Journal Article
Boyd-Carson, H., Doleman, B., Lockwood, S., Williams, J. P., Tierney, G. M., & Lund, J. N. (2020). Trainee-led emergency laparotomy operating. British Journal of Surgery, 107(10), 1289-1298. https://doi.org/10.1002/bjs.11611

© 2020 BJS Society Ltd Published by John Wiley & Sons Ltd Background: To achieve completion of training in general surgery, trainees are required to demonstrate competency in common procedures performed at emergency laparotomy. The aim of this stud... Read More about Trainee-led emergency laparotomy operating.

High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial (2020)
Journal Article
Blackwell, J. E. M., Doleman, B., Boereboom, C. L., Morton, A., Williams, S., Atherton, P., …Lund, J. N. (2020). High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial. Prostate Cancer and Prostatic Diseases, 23, 696–704. https://doi.org/10.1038/s41391-020-0219-1

Objectives

To assess the efficacy of high-intensity interval training (HIIT) for improving cardiorespiratory fitness (CRF) in patients awaiting resection for urological malignancy within four weeks.

Subjects/patients and methods

A randomised... Read More about High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial.

Therapeutic Resolution of Focal, Predominantly Anastomotic Crohn’s Disease Strictures Using Removable Stents: Outcomes from a Single-Center United Kingdom Case Series (2020)
Journal Article
Cole, A., Das, R., Goddard, A., Singh, R., Fraser, C., Din, S., …Hearing, S. (2020). Therapeutic Resolution of Focal, Predominantly Anastomotic Crohn’s Disease Strictures Using Removable Stents: Outcomes from a Single-Center United Kingdom Case Series. Gastrointestinal Endoscopy, 92(2), 344-352. https://doi.org/10.1016/j.gie.2020.01.053

Background and Aims
Intestinal and anastomotic strictures in Crohn’s disease (CD) produce considerable morbidity The development of surgery sparing, endoscopic modalities for stricture resolution is essential. Removable stent therapy is emerging as... Read More about Therapeutic Resolution of Focal, Predominantly Anastomotic Crohn’s Disease Strictures Using Removable Stents: Outcomes from a Single-Center United Kingdom Case Series.

Delay in Source Control in Perforated Peptic Ulcer Leads to 6% Increased Risk of Death Per Hour: A Nationwide Cohort Study (2019)
Journal Article
Boyd-Carson, H., Doleman, B., Cromwell, D., Lockwood, S., Williams, J. P., Tierney, G. M., …for The National Emergency Laparotomy Audit Collaboration. (2019). Delay in Source Control in Perforated Peptic Ulcer Leads to 6% Increased Risk of Death Per Hour: A Nationwide Cohort Study. World Journal of Surgery, 44, 869–875. https://doi.org/10.1007/s00268-019-05254-x

© 2019, Société Internationale de Chirurgie. Background: Delay to theatre for patients with intra-abdominal sepsis is cited as a particular risk factor for death. Our aim was to evaluate the potential relationship between hourly delay from admission... Read More about Delay in Source Control in Perforated Peptic Ulcer Leads to 6% Increased Risk of Death Per Hour: A Nationwide Cohort Study.

A double-blind randomized controlled trial of the effects of eicosapentaenoic acid supplementation on muscle inflammation and physical function in patients undergoing colorectal cancer resection (2019)
Journal Article
Hossain, T., Phillips, B. E., Doleman, B., Lund, J. N., & Williams, J. P. (2020). A double-blind randomized controlled trial of the effects of eicosapentaenoic acid supplementation on muscle inflammation and physical function in patients undergoing colorectal cancer resection. Clinical Nutrition, 39(7), 2055-2061. https://doi.org/10.1016/j.clnu.2019.09.009

Background

Resection of colorectal cancer (CRC) initiates inflammation, mediated at least partly by NFĸB (nuclear factor kappa-light-chain-enhancer of activated B-cells), leading to muscle catabolism and reduced physical performance. Eicosapentaen... Read More about A double-blind randomized controlled trial of the effects of eicosapentaenoic acid supplementation on muscle inflammation and physical function in patients undergoing colorectal cancer resection.

Long-term outcomes of biological mesh repair following extra levator abdominoperineal excision of the rectum: an observational study of 100 patients (2019)
Journal Article
Thomas, P. W., Blackwell, J. E. M., Herrod, P. J. J., Peacock, O., Singh, R., Williams, J. P., …Lund, J. N. (2019). Long-term outcomes of biological mesh repair following extra levator abdominoperineal excision of the rectum: an observational study of 100 patients. Techniques in Coloproctology, 23(8), 761-767. https://doi.org/10.1007/s10151-019-02056-0

Background
Current evidence suggests that pelvic floor reconstruction following extralevator abdominoperineal excision of rectum (ELAPER) may reduce the risk of perineal herniation of intra-abdominal contents. Options for reconstruction include mesh... Read More about Long-term outcomes of biological mesh repair following extra levator abdominoperineal excision of the rectum: an observational study of 100 patients.

Why most published meta-analysis findings are false (2019)
Journal Article
Doleman, B., Williams, J. P., & Lund, J. (2019). Why most published meta-analysis findings are false. Techniques in Coloproctology, 23(9), 925-928. https://doi.org/10.1007/s10151-019-02020-y

Almost a decade after the controversial paper ‘why most published research findings are false’ was written [1], we re-visit this concern with regard to published meta-analyses. Although reading the title of this article may make some pause for though... Read More about Why most published meta-analysis findings are false.

Short-term pre-operative high-intensity interval training does not improve fitness of colorectal cancer patients (2019)
Journal Article
Boereboom, C. L., Blackwell, J. E., Williams, J. P., Phillips, B. E., & Lund, J. N. (2019). Short-term pre-operative high-intensity interval training does not improve fitness of colorectal cancer patients. Scandinavian Journal of Medicine and Science in Sports, 29(9), 1383-1391. https://doi.org/10.1111/sms.13460

Background: Preoperative cardiorespiratory fitness (CRF) in colorectal cancer patients has been shown to affect postoperative outcomes. The aim of this study was to test the feasibility of high-intensity interval training (HIT) for improving fitness... Read More about Short-term pre-operative high-intensity interval training does not improve fitness of colorectal cancer patients.

Association between surgeon special interest and mortality after emergency laparotomy (2019)
Journal Article
Boyd‐Carson, H., Doleman, B., Herrod, P. J. J., Anderson, I. D., Williams, J. P., Lund, J. N., …on behalf of the NELA Collaboration. (2019). Association between surgeon special interest and mortality after emergency laparotomy. British Journal of Surgery, 106(7), 940-948. https://doi.org/10.1002/bjs.11146

© 2019 BJS Society Ltd Published by John Wiley & Sons Ltd Background: Approximately 30 000 emergency laparotomies are performed each year in England and Wales. Patients with pathology of the gastrointestinal tract requiring emergency laparotomy are... Read More about Association between surgeon special interest and mortality after emergency laparotomy.

The acute transcriptional response to resistance exercise: impact of age and contraction mode (2019)
Journal Article
Deane, C. S., Ames, R. M., Phillips, B. E., Weedon, M. N., Willis, C. R., Boereboom, C., …Etheridge, T. (2019). The acute transcriptional response to resistance exercise: impact of age and contraction mode. Aging, 11(7), 2111-2126. https://doi.org/10.18632/aging.101904

Optimization of resistance exercise (RE) remains a hotbed of research for muscle building and maintenance. However, the interactions between the contractile components of RE (i.e. concentric (CON) and eccentric (ECC)) and age, are poorly defined. We... Read More about The acute transcriptional response to resistance exercise: impact of age and contraction mode.