An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation

Saffaran, Sina; Wang, Wenfei; Das, Anup; Schmitt, Walter; Becker-Pelster, Eva-Maria; Hardman, Jonathan G.; Weimann, Gerrit; Bates, Declan G.

doi:10.1002/psp4.12308

All Outputs (4)

Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea (2018)
Journal Article

Background Apnoeic oxygenation can come close to matching the oxygen demands of the apnoeic patient but does not facilitate carbon dioxide (CO2) elimination, potentially resulting in dangerous hypercapnia. Numerous studies have shown that high-flo... Read More about Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea.

Validity and reliability of an objective structured assessment tool for performance of ultrasound-guided regional anaesthesia (2018)
Journal Article

Background: We aimed to examine the validity and reliability of previously developed criterion-referenced assessment checklist (AC) and global rating scale (GRS) to assess performance in ultrasound-guided regional anaesthesia (UGRA). Methods: Twenty... Read More about Validity and reliability of an objective structured assessment tool for performance of ultrasound-guided regional anaesthesia.

Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score (2018)
Journal Article

Objectives: Postintubation laryngotracheal injury is common. Assessment of histopathological changes currently requires animal models. We set about developing a viable, resource effective animal model to study these effects and to develop a detailed... Read More about Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score.

An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation (2018)
Journal Article

This study uses a highly fidelity computational simulator of pulmonary physiology to evaluate the impact of a soluble guanylate cyclase (sGC) modulator on gas exchange in patients with chronic obstructive pulmonary disease (COPD) and pulmonary hypert... Read More about An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation.