Evaluation of the physiological properties of ventilatory ratio in a computational cardiopulmonary model and its clinical application in an acute respiratory distress syndrome population

Sinha, Pratik; Hardman, Jonathan; Singh, Suveer; Bersten, Andrew D.; Soni, Neil C.

doi:10.1093/bja/aet283

All Outputs (26)

An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation (2018)
Journal Article

This study uses a highly fidelity computational simulator of pulmonary physiology to evaluate the impact of a soluble guanylate cyclase (sGC) modulator on gas exchange in patients with chronic obstructive pulmonary disease (COPD) and pulmonary hypert... Read More about An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation.

Investigating the effect of cardiac oscillations and deadspace gas mixing during apnea using computer simulation (2017)
Conference Proceeding

Gaseous mixing in the anatomical deadspace with stimulation of respiratory ventilation through cardiogenic oscillations is an important physiological mechanism at the onset of apnea, which has been credited with various beneficial effects, e.g. reduc... Read More about Investigating the effect of cardiac oscillations and deadspace gas mixing during apnea using computer simulation.

Cohort study of preoperative blood pressure and risk of 30-day mortality after elective non-cardiac surgery (2017)
Journal Article

Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome (2017)
Journal Article

Background: Clinical trials have, so far, failed to establish clear beneficial outcomes of recruitment maneuvers (RMs) on patient mortality in acute respiratory distress syndrome (ARDS), and the effects of RMs on the cardiovascular system remain poor... Read More about Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome.

High PEEP in acute respiratory distress syndrome: quantitative evaluation between improved arterial oxygenation and decreased oxygen delivery (2016)
Journal Article

Background: Positive end-expiratory pressure (PEEP) is widely used to improve oxygenation and prevent alveolar collapse in mechanically ventilated patients with the acute respiratory distress syndrome (ARDS). While PEEP predictably improves arterial... Read More about High PEEP in acute respiratory distress syndrome: quantitative evaluation between improved arterial oxygenation and decreased oxygen delivery.

Evaluation of the physiological properties of ventilatory ratio in a computational cardiopulmonary model and its clinical application in an acute respiratory distress syndrome population (2014)
Journal Article