Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33

Tarr, Alexander W.; Owsianka, Ania M.; Timms, Judith M.; McClure, C. Patrick; Brown, Richard J.P.; Hickling, Timothy P.; Pietschmann, Thomas; Bartenschlager, Ralf; Patel, Arvind H.; Ball, Jonathan K.

doi:10.1002/hep.21088

All Outputs (2)

Identification of Conserved Residues in the E2 Envelope Glycoprotein of the Hepatitis C Virus That Are Critical for CD81 Binding (2006)
Journal Article

Hepatitis C virus (HCV) cell entry involves interaction between the viral envelope glycoprotein E2 and the cell surface receptor CD81. Knowledge of conserved E2 determinants important for successful binding will facilitate development of entry inhibi... Read More about Identification of Conserved Residues in the E2 Envelope Glycoprotein of the Hepatitis C Virus That Are Critical for CD81 Binding.

Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33 (2006)
Journal Article

The mouse monoclonal antibody (MAb) AP33, recognizing a 12 amino acid linear epitope in the hepatitis C virus (HCV) E2 glycoprotein, potently neutralizes retroviral pseudoparticles (HCVpp) carrying genetically diverse HCV envelope glycoproteins. Cons... Read More about Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33.