Research Repository

See what's under the surface


Intracellular processing of silica-coated superparamagnetic iron nanoparticles in human mesenchymal stem cells (2019)
Journal Article
Harrison, R. P., Chauhan, V. M., Onion, D., Aylott, J. W., & Sottile, V. (2019). Intracellular processing of silica-coated superparamagnetic iron nanoparticles in human mesenchymal stem cells. RSC Advances, 9, 3176-3184. doi:10.1039/C8RA09089K

Silica-coated Superparamagnetic Iron Nanoparticles (SiMAGs) are an exciting biomedical technology capable of targeted delivery of cell-based therapeutics and disease diagnosis. However, in order to realise their full clinical potential, their intrace... Read More

New generation of bioreactors that advance extracellular matrix modelling and tissue engineering (2018)
Journal Article
Ahmed, S., Chauhan, V. M., Ghaemmaghami, A. M., & Aylott, J. W. (2018). New generation of bioreactors that advance extracellular matrix modelling and tissue engineering. Biotechnology Letters, doi:10.1007/s10529-018-2611-7

Bioreactors hold a lot of promise for tissue engineering and regenerative medicine applications. They have multiple uses including cell cultivation for therapeutic production and for in vitro organ modelling to provide a more physiologically relevant... Read More

Enhanced distance-dependent fluorescence quenching using size tuneable core shell silica nanoparticles (2018)
Journal Article
Elsutohy, M. M., Selo, A., Chauhan, V. M., Tendler, S. J., & Aylott, J. W. (2018). Enhanced distance-dependent fluorescence quenching using size tuneable core shell silica nanoparticles. RSC Advances, 8(62), doi:10.1039/C8RA05929B

Silica nanoparticles (SNPs) have been used as favoured platforms for sensor, drug delivery and biological imaging applications, due to their ease of synthesis, size-control and bespoke physico-chemical properties. In this study, we have developed a p... Read More

The physicochemical fingerprint of Necator americanus (2017)
Journal Article
Chauhan, V. M., Scurr, D. J., Christie, T., Telford, G., Aylott, J. W., & Pritchard, D. (in press). The physicochemical fingerprint of Necator americanus. PLoS Neglected Tropical Diseases, 11(12), doi:10.1371/journal.pntd.0005971. ISSN 1935-2735

Necator americanus, a haematophagous hookworm parasite, infects ~10% of the world’s population and is considered to be a significant public health risk. Its lifecycle has distinct stages, permitting its successful transit from the skin via the lungs... Read More

Control of aggregation temperatures in mixed and blended cytocompatible thermoresponsive block co-polymer nanoparticles (2017)
Journal Article
Foralosso, R., Moir, L., Mastrotto, F., Sasso, L., Tchoryk, A., Abouselo, A., …Alexander, C. (2017). Control of aggregation temperatures in mixed and blended cytocompatible thermoresponsive block co-polymer nanoparticles. Soft Matter, 40(13), doi:10.1039/c7sm00920h. ISSN 1744-683X

A small library of thermoresponsive amphiphilic copolymers based on polylactide-block-poly((2-(2-methoxyethoxy)ethyl methacrylate)-co-(oligoethylene glycol methacrylate)) (PLA-b-P(DEGMA)-co-(OEGMA)), was synthesised by copper-mediated controlled radi... Read More

Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes (2016)
Journal Article
Rawson, F. J., Cole, M., Hicks, J., Aylott, J. W., Milne, W., Collins, C., …Mendes, P. M. (in press). Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes. Scientific Reports, 6(37672), doi:10.1038/srep37672. ISSN 2045-2322

With the rapidly increasing demands for ultrasensitive biodetection, the design and applications of new nano-scale materials for development of sensors based on optical and electrochemical transducers have attracted substantial interest. In particula... Read More

Quadruple labelled dual oxygen and pH-sensitive ratiometric nanosensors (2016)
Journal Article
Chauhan, V. M., Giuntini, F., & Aylott, J. W. (2016). Quadruple labelled dual oxygen and pH-sensitive ratiometric nanosensors. Sensing and Bio-Sensing Research, 8, doi:10.1016/j.sbsr.2016.03.007. ISSN 2214-1804

Nanosensors capable of simultaneously measuring dissolved oxygen concentrations from 0 to 100% saturation and pH over the full physiological range, from pH 3.5 to 7.5, that advance the methods towards understanding of key biological gradients, were s... Read More

Indomethacin-Kollidon VA64 extrudates: a mechanistic study of pH-dependent controlled release (2016)
Journal Article
Tres, F., Treacher, K., Booth, J., Hughes, L. P., Wren, S. A., Aylott, J., & Burley, J. (2016). Indomethacin-Kollidon VA64 extrudates: a mechanistic study of pH-dependent controlled release. Molecular Pharmaceutics, 13(3), 1166–1175. doi:10.1021/acs.molpharmaceut.5b00979

Because of its weakly acidic nature (pKa of 4.5), indomethacin presents an aqueous solubility that significantly increases when changing from acidic to neutral/alkaline pH (1.5 μg/mL at pH 1.2 and 105.2 μg/mL at pH 7.4). We have therefore investigate... Read More

Facile approach to generating polymeric nanoarrays containing populations of nanoparticles (2015)
Journal Article
Marques, L., Chen, X., Roberts, C. J., Clark, M., & Aylott, J. W. (2015). Facile approach to generating polymeric nanoarrays containing populations of nanoparticles. Micro and Nano Letters, 10(8), 378-383. doi:10.1049/mnl.2015.0041

The production of nanoarrays containing a population of entrapped, heterogeneous nanoparticles is reported. The nanoarray consists of a nanoporous film with pores of diameter 60-180 nm, formed from the phase separation of two immiscible polymers: pol... Read More

Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping (2015)
Journal Article
Tres, F., Aylott, J., Patient, J. D., Williams, P. M., Treacher, K., Booth, J., …Burley, J. C. (2015). Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping. Molecular Pharmaceutics, 12(5), 1512–1522. doi:10.1021/mp500829v

Real-time in situ Raman mapping has been employed to monitor, during dissolution, the crystallization transitions of amorphous bicalutamide formulated as a molecular dispersion in a copovidone VA64 matrix. The dissolution performance was also investi... Read More

Optically excited nanoscale ultrasonic transducers (2015)
Journal Article
Smith, R. J., Cota, F. P., Marques, L., Chen, X., Arca, A., Webb, K., …Clark, M. (2015). Optically excited nanoscale ultrasonic transducers. Journal of the Acoustical Society of America, 137(1), doi:10.1121/1.4904487. ISSN 0001-4966

In order to work at higher ultrasonic frequencies, for instance, to increase the resolution, it is necessary to fabricate smaller and higher frequency transducers. This paper presents an ultrasonic transducer capable of being made at a very small siz... Read More

An appraisal of the Suzuki cross-coupling reaction for the synthesis of novel fluorescent coumarin derivatives (2014)
Journal Article
Alhaj Zen, A., Aylott, J. W., & Chan, W. C. (2014). An appraisal of the Suzuki cross-coupling reaction for the synthesis of novel fluorescent coumarin derivatives. Tetrahedron Letters, 55(40), doi:10.1016/j.tetlet.2014.08.058. ISSN 0040-4039

We report the chemical design and development of 3-aryl-substituted 7-alkoxy-4-methylcoumarins with enhanced fluorogenic properties. The 3-aryl substituents are installed via an optimized Suzuki–Miyaura cross-coupling (SMC) reaction between a 7-alkox... Read More