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New generation of bioreactors that advance extracellular matrix modelling and tissue engineering

Ahmed, Shehnaz; Chauhan, Veeren M.; Ghaemmaghami, Amir M.; Aylott, Jonathan W.


Shehnaz Ahmed


Bioreactors hold a lot of promise for tissue engineering and regenerative medicine applications. They have multiple uses including cell cultivation for therapeutic production and for in vitro organ modelling to provide a more physiologically relevant environment for cultures compared to conventional static conditions. Bioreactors are often used in combination with scaffolds as the nutrient flow can enhance oxygen and diffusion throughout the 3D constructs to prevent the formation of necrotic cores. A variety of scaffolds have been fabricated to achieve a structural architecture that mimic native extracellular matrix. Future developments of in vitro models will incorporate the ability to non-invasively monitor the cellular microenvironment to enhance the understanding of in vitro conditions. This review details current advancements in bioreactor and scaffold systems and provides insight on how in vitro models can be augmented for future biomedical applications.


Ahmed, S., Chauhan, V. M., Ghaemmaghami, A. M., & Aylott, J. W. (2019). New generation of bioreactors that advance extracellular matrix modelling and tissue engineering. Biotechnology Letters, 41(1), 1–25.

Journal Article Type Article
Acceptance Date Sep 26, 2018
Online Publication Date Oct 27, 2018
Publication Date 2019-01
Deposit Date Oct 11, 2018
Publicly Available Date Oct 11, 2018
Journal Biotechnology Letters
Print ISSN 0141-5492
Electronic ISSN 1573-6776
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 41
Issue 1
Pages 1–25
Public URL
Publisher URL


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