New generation of bioreactors that advance extracellular matrix modelling and tissue engineering

Ahmed, Shehnaz; Chauhan, Veeren M.; Ghaemmaghami, Amir M.; Aylott, Jonathan W.

Abstract

Bioreactors hold a lot of promise for tissue engineering and regenerative medicine applications. They have multiple uses including cell cultivation for therapeutic production and for in vitro organ modelling to provide a more physiologically relevant environment for cultures compared to conventional static conditions. Bioreactors are often used in combination with scaffolds as the nutrient flow can enhance oxygen and diffusion throughout the 3D constructs to prevent the formation of necrotic cores. A variety of scaffolds have been fabricated to achieve a structural architecture that mimic native extracellular matrix. Future developments of in vitro models will incorporate the ability to non-invasively monitor the cellular microenvironment to enhance the understanding of in vitro conditions. This review details current advancements in bioreactor and scaffold systems and provides insight on how in vitro models can be augmented for future biomedical applications.

Citation

Ahmed, S., Chauhan, V. M., Ghaemmaghami, A. M., & Aylott, J. W. (2019). New generation of bioreactors that advance extracellular matrix modelling and tissue engineering. Biotechnology Letters, 41(1), 1–25. https://doi.org/10.1007/s10529-018-2611-7

• Journal Article Type: Article
• Acceptance Date: Sep 26, 2018
• Online Publication Date: Oct 27, 2018
• Publication Date: 2019-01
• Deposit Date: Oct 11, 2018
• Publicly Available Date: Oct 11, 2018
• Journal: Biotechnology Letters
• Print ISSN: 0141-5492
• Electronic ISSN: 1573-6776
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 41
• Issue: 1
• Pages: 1–25
• DOI: https://doi.org/10.1007/s10529-018-2611-7
• Public URL: https://nottingham-repository.worktribe.com/output/1161049
• Publisher URL: https://link.springer.com/article/10.1007%2Fs10529-018-2611-7