All Outputs (7)

Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes (2022)
Journal Article

The translation of new injectable anaesthetic drugs from rodent to humans remains slow, despite the realisation that reliance on the volatile agents is unsustainable from an environmental perspective. The aim of this study was to investigate the infl... Read More about Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes.

Clinical measurements performed during alfaxalone total intravenous anaesthesia for radiography and neurophysiological investigations in dogs (2019)
Journal Article

Objective: To describe clinically relevant, physiological measurements collected during a 3- hour duration alfaxalone total intravenous anaesthesia. Study design: Case series. Animals: A total of 112 client-owned middle aged or older dogs. Methods... Read More about Clinical measurements performed during alfaxalone total intravenous anaesthesia for radiography and neurophysiological investigations in dogs.

Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis (2018)
Journal Article

In man, central sensitisation (CS) contributes to the pain of osteoarthritis (OA). Dogs with spontaneous OA may also exhibit CS. Electrophysiological reflex measurements are more objective than behavioural assessments, and can be used to evaluate CS... Read More about Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis.

Gainfully employing descending controls in acute and chronic pain management (2018)
Journal Article

Specific primary afferent fibres termed nociceptors are responsible for transmitting nociceptive information. Centrally the axonal terminals of these fibres synapse with secondary projection neurones in the spinal dorsal horn to transmit nociceptive... Read More about Gainfully employing descending controls in acute and chronic pain management.

A clinical evaluation of the pharmacokinetics and pharmacodynamics of intravenous alfaxalone in cyclodextrin in male and female rats following a loading dose and constant rate infusion (2017)
Journal Article

Objective: To characterise, as a clinical study, the pharmacokinetics and pharmacodynamics and describe the hypnotic effect of the neurosteroid alfaxalone (3?-hydroxy-5 ?-pregnane-11, 20-dione) formulated with 2-hydroxypropyl-?-cyclodextrin in male a... Read More about A clinical evaluation of the pharmacokinetics and pharmacodynamics of intravenous alfaxalone in cyclodextrin in male and female rats following a loading dose and constant rate infusion.

Alfaxalone anaesthesia facilitates electrophysiological recordings of nociceptive withdrawal reflexes in dogs (Canis familiaris) (2016)
Journal Article

Naturally occurring canine osteoarthritis represents a welfare issue for affected dogs (Canis familiaris), but is also considered very similar to human osteoarthritis and has therefore been proposed as a model of disease in humans. Central sensitisat... Read More about Alfaxalone anaesthesia facilitates electrophysiological recordings of nociceptive withdrawal reflexes in dogs (Canis familiaris).

Involvement of spinal ??-adrenoceptors in prolonged modulation of hind limb withdrawal reflexes following acute noxious stimulation in the anaesthetized rabbit (2016)
Journal Article

The role of spinal α₂-adrenoceptors in mediating long-lasting modulation of hind limb withdrawal reflexes following acute noxious chemical stimulation of distant heterotopic and local homotopic locations has been investigated in pentobarbitone-anaest... Read More about Involvement of spinal ??-adrenoceptors in prolonged modulation of hind limb withdrawal reflexes following acute noxious stimulation in the anaesthetized rabbit.