All Outputs (73)

Effects of feeding earthworm or vermicompost on early life performance of broilers under challenging dietary conditions (2024)
Journal Article
Daş, G., Brameld, J. M., Parr, T., Seyedalmoosavi, M. M., Görs, S., & Metges, C. C. (2024). Effects of feeding earthworm or vermicompost on early life performance of broilers under challenging dietary conditions. Poultry Science, 103(12), Article 104341. https://doi.org/10.1016/j.psj.2024.104341

We investigated if feeding earthworms (EW) or vermicompost (VC) to broilers improves performance and aids in coping with dietary challenges from a soluble non-starch polysaccharide (NSP)-enriched diet (negative control diet; CON-).... Read More about Effects of feeding earthworm or vermicompost on early life performance of broilers under challenging dietary conditions.

Magnolol Loaded Polydopamine-Chitosan Coated pH-responsive Nanoparticles for Alleviation of Ulcerative Colitis (2024)
Journal Article
Mu, G., Peng, F., Zhang, Z., M. Brameld, J., Rose, P., Yang, X., Jiang, Z.-J., He, X., & Tang, B. (2024). Magnolol Loaded Polydopamine-Chitosan Coated pH-responsive Nanoparticles for Alleviation of Ulcerative Colitis. Journal of Drug Delivery Science and Technology, 101(Part A), Article 106151. https://doi.org/10.1016/j.jddst.2024.106151

This study designed and developed a novel three-layer electrostatic, slow-releasing nanoparticle drug delivery system for the treatment of ulcerative colitis. The nanoparticles were composed of layers of zein-based polydopamine, chitosan and cellulos... Read More about Magnolol Loaded Polydopamine-Chitosan Coated pH-responsive Nanoparticles for Alleviation of Ulcerative Colitis.

The juvenile hormone analogue, pyriproxifen, alters protein and fat composition of Tenebrio molitor larvae (2024)
Journal Article
Hill, V., Lopez-Viso, C., Brameld, J., Salter, A., & Parr, T. (2024). The juvenile hormone analogue, pyriproxifen, alters protein and fat composition of Tenebrio molitor larvae. Journal of Insects as Food and Feed, https://doi.org/10.1163/23524588-00001043

Maximising the yield of product from livestock is common practice in the agriculture industry and there is potential to extend this practice to the emerging insect industry, to produce high-quality, sustainable protein. Tenebrio molitor larvae, commo... Read More about The juvenile hormone analogue, pyriproxifen, alters protein and fat composition of Tenebrio molitor larvae.

Active vitamin D increases myogenic differentiation in C2C12 cells via a vitamin D response element on the myogenin promoter (2024)
Journal Article
Alliband, K. H., Parr, T., Jethwa, P. H., & Brameld, J. M. (2024). Active vitamin D increases myogenic differentiation in C2C12 cells via a vitamin D response element on the myogenin promoter. Frontiers in Physiology, 14, Article 1322677. https://doi.org/10.3389/fphys.2023.1322677

Background: Skeletal muscle development during embryogenesis depends on proliferation of myoblasts followed by differentiation into myotubes/multinucleated myofibers. Vitamin D (VD) has been shown to affect these processes, but there is conflicting e... Read More about Active vitamin D increases myogenic differentiation in C2C12 cells via a vitamin D response element on the myogenin promoter.

Changes in nutrient composition and gene expression in growing mealworms (Tenebrio molitor) (2023)
Journal Article
Lopez-Viso, C., Castellanos-Uribe, M., May, T., Brameld, J., Salter, A., & Parr, T. (2023). Changes in nutrient composition and gene expression in growing mealworms (Tenebrio molitor). Journal of Insects as Food and Feed, 10(4), 601-610. https://doi.org/10.1163/23524588-20230143

Insects are of high interest as a sustainable source of nutrients to be included in the food production system. The larvae of Tenebrio molitor, commonly known as yellow mealworms (MW), have a high protein content, which means potential applications i... Read More about Changes in nutrient composition and gene expression in growing mealworms (Tenebrio molitor).

In vitro determination of the protein quality of maize varieties cultivated in Malawi using the INFOGEST digestion method. (2023)
Journal Article
Muleya, M., Li, D., Chiutsi-Phiri, G., Botoman, L., Brameld, J. M., & Salter, A. M. (2023). In vitro determination of the protein quality of maize varieties cultivated in Malawi using the INFOGEST digestion method. Heliyon, 9(9), Article e19797. https://doi.org/10.1016/j.heliyon.2023.e19797

There is an urgent need to alleviate protein deficiencies in low-income countries where cereal-based diets dominate. The objective of this study was to use the INFOGEST static digestion method and a recently established analytical workflow to determi... Read More about In vitro determination of the protein quality of maize varieties cultivated in Malawi using the INFOGEST digestion method..

Fermentation technology enhances the nutritional quality of underutilized Bambara groundnut – a review (2023)
Journal Article
Tee, A. J., Lim, Y. S., Brameld, J. M., Massawe, F., Parr, T., & Salter, A. M. (2023). Fermentation technology enhances the nutritional quality of underutilized Bambara groundnut – a review. Food Biotechnology, 37(2), 106-135. https://doi.org/10.1080/08905436.2023.2201307

Bambara groundnut (BG) offers great potential for sustainable food and nutritional security in the face of a growing population and changing climate. However, its utilization remains restricted by the hard-to-cook phenomenon of seed and the presence... Read More about Fermentation technology enhances the nutritional quality of underutilized Bambara groundnut – a review.

A Comparison of Primary Human Hepatocytes and Hepatoma Cell Lines to Model the Effects of Fatty Acids, Fructose and Glucose on Liver Cell Lipid Accumulation (2022)
Journal Article
Huggett, Z. J., Smith, A., De Vivo, N., Gomez, D., Jethwa, P., Brameld, J. M., …Salter, A. M. (2022). A Comparison of Primary Human Hepatocytes and Hepatoma Cell Lines to Model the Effects of Fatty Acids, Fructose and Glucose on Liver Cell Lipid Accumulation. Nutrients, 15(1), Article 40. https://doi.org/10.3390/nu15010040

Non-alcoholic fatty liver disease (NAFLD) begins with lipid accumulation within hepatocytes, but the relative contributions of different macronutrients is still unclear. We investigated the impact of fatty acids, glucose and fructose on lipid accumul... Read More about A Comparison of Primary Human Hepatocytes and Hepatoma Cell Lines to Model the Effects of Fatty Acids, Fructose and Glucose on Liver Cell Lipid Accumulation.

The effects of exogenous fibrolytic enzymes on the in vitro release of xylooligosaccharides and monosaccharides varies across six varieties of wheat (2022)
Journal Article
Dale, T., Bedford, M. R., King, J., Tucker, G. A., Brameld, J. M., & Parr, T. (2023). The effects of exogenous fibrolytic enzymes on the in vitro release of xylooligosaccharides and monosaccharides varies across six varieties of wheat. Animal Feed Science and Technology, 295, Article 115526. https://doi.org/10.1016/j.anifeedsci.2022.115526

Wheat is a widely used cereal grain for pig and poultry feeds globally. Despite this, there are noticeable differences in its nutritive value, potentially due to varying characteristics like inherent non-starch polysaccharide (NSP) content and compos... Read More about The effects of exogenous fibrolytic enzymes on the in vitro release of xylooligosaccharides and monosaccharides varies across six varieties of wheat.

The Winged Bean Genome: Winged Bean—One Species Supermarket (2022)
Book Chapter
Tsoutsoura, N., Chong, Y. T., Ho, W. K., Chai, H. H., Tanzi, A. S., Salazar-Licea, L., …Mayes, S. (2022). The Winged Bean Genome: Winged Bean—One Species Supermarket. In M. A. Chapman (Ed.), Underutilised Crop Genomes (315-336). Springer International Publishing. https://doi.org/10.1007/978-3-031-00848-1_17

Climate change, population growth and increasingly homogenised diets are a threat to food security and human nutritional status. There is an urgent need to incorporate highly nutritious crops into the human diet to provide new sources of nutrition, t... Read More about The Winged Bean Genome: Winged Bean—One Species Supermarket.

In vitro Effects of Biologically Active Vitamin D on Myogenesis: A Systematic Review (2021)
Journal Article
Alliband, K. H., Kozhevnikova, S. V., Parr, T., Jethwa, P. H., & Brameld, J. M. (2021). In vitro Effects of Biologically Active Vitamin D on Myogenesis: A Systematic Review. Frontiers in Physiology, 12, Article 736708. https://doi.org/10.3389/fphys.2021.736708

Vitamin D (VD) deficiency is associated with muscle weakness. A reduction in the incidence of falls in the elderly following VD supplementation and identification of the VD receptor within muscle cells suggests a direct effect of VD on muscle, but li... Read More about In vitro Effects of Biologically Active Vitamin D on Myogenesis: A Systematic Review.

Suitability of insects for animal feeding. (2021)
Book Chapter
Hawkey, K., Brameld, J., Parr, T., Salter, A., & Hall, H. (2021). Suitability of insects for animal feeding. In H. Hall, E. Fitches, & R. Smith (Eds.), Insects as Animal Feed: Novel Ingredients for Use in Pet, Aquaculture and Livestock Diets (26-38). CAB International. https://doi.org/10.1079/9781789245929.0004

This chapter explores the nutritional composition of insects and the potential benefits and drawbacks for their inclusion into pet, poultry, pig, ruminant and aquatic animal feeds. Six species are most commonly described for use in animal feed, namel... Read More about Suitability of insects for animal feeding..

98 The effect of mezquite pod flour in a wheat-based diet on broiler chicken growth performance (2021)
Presentation / Conference Contribution
Bone, G., Parr, T., Brameld, J., Elmes, M., Gonzalez-Carranza, Z., & Koech, O. (2021). 98 The effect of mezquite pod flour in a wheat-based diet on broiler chicken growth performance. Animal - Science proceedings, 12(1), 77. https://doi.org/10.1016/j.anscip.2021.03.099

Application Inclusion of Mezquite pod flour in broiler chicken diets significantly reduced weight gain, this could inform a recommendation against the use of non-processed Mezquite in broiler chicken diets. Introduction Mezquite is an under-utilised... Read More about 98 The effect of mezquite pod flour in a wheat-based diet on broiler chicken growth performance.

Response of the porcine MYH4-promoter and MYH4-expressing myotubes to known anabolic and catabolic agents in vitro (2021)
Journal Article
Brearley, M. C., Loczenski-Brown, D. M., Loughna, P. T., Parr, T., & Brameld, J. M. (2021). Response of the porcine MYH4-promoter and MYH4-expressing myotubes to known anabolic and catabolic agents in vitro. Biochemistry and Biophysics Reports, 25, Article 100924. https://doi.org/10.1016/j.bbrep.2021.100924

© 2021 The Authors Myosin heavy chain-IIB (MyHC-IIB; encoded by MYH4 or Myh4) expression is often associated with muscle hypertrophic growth. Unlike other large mammals, domestic pig breeds express MyHC-IIB at both the mRNA and protein level. Aim: To... Read More about Response of the porcine MYH4-promoter and MYH4-expressing myotubes to known anabolic and catabolic agents in vitro.

The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells (2020)
Journal Article
Brearley, M. C., Daniel, Z. C., Loughna, P. T., Parr, T., & Brameld, J. M. (2020). The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells. Scientific Reports, 10, Article 22177. https://doi.org/10.1038/s41598-020-79324-9

Phosphoenolpyruvate carboxykinase (PEPCK) is a gluconeogenic enzyme with a cytosolic (Pck1/PEPCK-C) and mitochondrial (Pck2/PEPCK-M) isoform. Here we investigate the effect of 3-mercaptopicolinic acid (3-MPA), a PEPCK inhibitor, on C2C12 muscle cells... Read More about The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells.

Leucine and mTORc1 act independently to regulate 2-deoxyglucose uptake in L6 myotubes (2020)
Journal Article
Yin, Q., Brameld, J. M., Parr, T., & Murton, A. J. (2020). Leucine and mTORc1 act independently to regulate 2-deoxyglucose uptake in L6 myotubes. Amino Acids, 52, 477–486. https://doi.org/10.1007/s00726-020-02829-0

© 2020, The Author(s). Chronic mTORc1 hyperactivation via obesity-induced hyperleucinaemia has been implicated in the development of insulin resistance, yet the direct impact of leucine on insulin-stimulated glucose uptake in muscle cells remains unc... Read More about Leucine and mTORc1 act independently to regulate 2-deoxyglucose uptake in L6 myotubes.

Productivity framework (2018)
Journal Article
Wagstaff, C., Kendrick, F., Dennis, C., Hollington, P., Hess, T., Brameld, J., …Mason, B. (2018). Productivity framework. Food Science and Technology, 32(4), 56-61. https://doi.org/10.1002/fsat.3204_16.x

Researchers look at skills shortages and careers pathways in the agrifood industry. Sustaining the agriculture, food and drink industries requires human capital. Current estimates calculate that the agrifood supply chain employs approaching 4m people... Read More about Productivity framework.

Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth (2018)
Journal Article
Brown, D. M., Jones, S., Daniel, Z. C., Brearley, M. C., Lewis, J. E., Ebling, F. J., Parr, T., & Brameld, J. M. (2018). Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth. PLoS ONE, 13(7), Article e0201481. https://doi.org/10.1371/journal.pone.0201481

Previously, we highlighted induction of an integrated stress response (ISR) gene program in skeletal muscle of pigs treated with a beta-adrenergic agonist. Hence we tested the hypothesis that the ER-stress inhibitor, sodium 4-phenylbutyrate (PBA), wo... Read More about Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth.

Correction: Effects of insulin like growth factors on early embryonic chick limb myogenesis (2017)
Journal Article
Mohammed, R. H., Anderton, H., Brameld, J. M., & Sweetman, D. (2017). Correction: Effects of insulin like growth factors on early embryonic chick limb myogenesis. PLoS ONE, 12(12), Article e0189395. https://doi.org/10.1371/journal.pone.0189395

© 2017 Mohammed et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are c... Read More about Correction: Effects of insulin like growth factors on early embryonic chick limb myogenesis.

Effects of insulin like growth factors on early embryonic chick limb myogenesis (2017)
Journal Article
Mohammed, R. H., Anderton, H., Brameld, J. M., & Sweetman, D. (2017). Effects of insulin like growth factors on early embryonic chick limb myogenesis. PLoS ONE, 12(10), Article e0185775. https://doi.org/10.1371/journal.pone.0185775

Limb muscles derive from pax3 expressing precursor cells that migrate from the hypaxial somite into the developing limb bud. Once there they begin to differentiate and express muscle determination genes such as MyoD. This process is regulated by a co... Read More about Effects of insulin like growth factors on early embryonic chick limb myogenesis.