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Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth

Brown, David M.; Jones, Sarah; Daniel, Zoe C.T.R.; Brearley, Madelaine C.; Lewis, Jo E.; Ebling, Francis J.P.; Parr, Tim; Brameld, John M.


David M. Brown

Sarah Jones

Zoe C.T.R. Daniel

Madelaine C. Brearley

Jo E. Lewis

Francis J.P. Ebling

Professor of Nutritional Biochemistry

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Professor of Nutritional Biochemstry


Previously, we highlighted induction of an integrated stress response (ISR) gene program in skeletal muscle of pigs treated with a beta-adrenergic agonist. Hence we tested the hypothesis that the ER-stress inhibitor, sodium 4-phenylbutyrate (PBA), would inhibit Clenbuterol-mediated muscle growth and reduce expression of genes that are known indicators of an ISR in mice. Clenbuterol (1mg/kg/day) administered to C57BL6/J mice for 21 days increased body weight (p


Brown, D. M., Jones, S., Daniel, Z. C., Brearley, M. C., Lewis, J. E., Ebling, F. J., …Brameld, J. M. (2018). Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth. PLoS ONE, 13(7),

Journal Article Type Article
Acceptance Date Jul 19, 2018
Publication Date Jul 27, 2018
Deposit Date Jul 25, 2018
Publicly Available Date Jul 27, 2018
Journal PLoS ONE
Electronic ISSN 1932-6203
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 13
Issue 7
Article Number e0201481
Keywords Integrated stress response, beta-adrenergic agonist, ER-stress, hypertrophy, atrophy, activating transcription factor
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Copyright Statement Copyright information regarding this work can be found at the following address:


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