Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth

Brown, David M.; Jones, Sarah; Daniel, Zoe C.T.R.; Brearley, Madelaine C.; Lewis, Jo E.; Ebling, Francis J.P.; Parr, Tim; Brameld, John M.

Abstract

Previously, we highlighted induction of an integrated stress response (ISR) gene program in skeletal muscle of pigs treated with a beta-adrenergic agonist. Hence we tested the hypothesis that the ER-stress inhibitor, sodium 4-phenylbutyrate (PBA), would inhibit Clenbuterol-mediated muscle growth and reduce expression of genes that are known indicators of an ISR in mice. Clenbuterol (1mg/kg/day) administered to C57BL6/J mice for 21 days increased body weight (p

Citation

Brown, D. M., Jones, S., Daniel, Z. C., Brearley, M. C., Lewis, J. E., Ebling, F. J., …Brameld, J. M. (2018). Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth. PLoS ONE, 13(7), Article e0201481. https://doi.org/10.1371/journal.pone.0201481

• Journal Article Type: Article
• Acceptance Date: Jul 19, 2018
• Publication Date: Jul 27, 2018
• Deposit Date: Jul 25, 2018
• Publicly Available Date: Jul 27, 2018
• Journal: PLoS ONE
• Electronic ISSN: 1932-6203
• Publisher: Public Library of Science
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 7
• Article Number: e0201481
• DOI: https://doi.org/10.1371/journal.pone.0201481
• Keywords: Integrated stress response, beta-adrenergic agonist, ER-stress, hypertrophy, atrophy, activating transcription factor
• Public URL: https://nottingham-repository.worktribe.com/output/947941
• Publisher URL: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201481