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Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth

Brown, David M.; Jones, Sarah; Daniel, Zoe C.T.R.; Brearley, Madelaine C.; Lewis, Jo E.; Ebling, Francis J.P.; Parr, Tim; Brameld, John M.

Authors

David M. Brown

Sarah Jones

Zoe C.T.R. Daniel

Madelaine C. Brearley

Jo E. Lewis

Francis J.P. Ebling fran.ebling@nottingham.ac.uk

TIM PARR tim.parr@nottingham.ac.uk
Professor of Nutritional Biochemistry

JOHN BRAMELD JOHN.BRAMELD@NOTTINGHAM.AC.UK
Professor of Nutritional Biochemstry



Abstract

Previously, we highlighted induction of an integrated stress response (ISR) gene program in skeletal muscle of pigs treated with a beta-adrenergic agonist. Hence we tested the hypothesis that the ER-stress inhibitor, sodium 4-phenylbutyrate (PBA), would inhibit Clenbuterol-mediated muscle growth and reduce expression of genes that are known indicators of an ISR in mice. Clenbuterol (1mg/kg/day) administered to C57BL6/J mice for 21 days increased body weight (p

Citation

Brown, D. M., Jones, S., Daniel, Z. C., Brearley, M. C., Lewis, J. E., Ebling, F. J., …Brameld, J. M. (2018). Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth. PLoS ONE, 13(7), https://doi.org/10.1371/journal.pone.0201481

Journal Article Type Article
Acceptance Date Jul 19, 2018
Publication Date Jul 27, 2018
Deposit Date Jul 25, 2018
Publicly Available Date Jul 27, 2018
Journal PLoS ONE
Electronic ISSN 1932-6203
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 13
Issue 7
Article Number e0201481
DOI https://doi.org/10.1371/journal.pone.0201481
Keywords Integrated stress response, beta-adrenergic agonist, ER-stress, hypertrophy, atrophy, activating transcription factor
Public URL http://eprints.nottingham.ac.uk/id/eprint/53139
Publisher URL http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201481
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

Files

journal.pone.0201481.pdf (3.2 Mb)
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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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