Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability

Butcher, Adrian; Robinson, Susan W.; Bourgognon, Julie-Myrtille; Spiers, Jereme G.; Breda, Carlo; Morone, Nobuhiro; Mistry, Raj; Campesan, Susanna; Challiss, R. A. John; Giorgini, Flaviano; Mallucci, Giovanna R.; Smith, Tim M.; Dinsdale, David; Guerra-Martin, Maria; Steinert, Joern R.

doi:10.1371/journal.pbio.2003611

Research Repository

All Outputs (2)

Alterations in neuronal metabolism contribute to the pathogenesis of prion disease (2018)
Journal Article

Neurodegenerative conditions are characterised by a progressive loss of neurons, which is believed to be initiated by misfolded protein aggregations. During this time period, many physiological and metabolomic alterations and changes in gene expressi... Read More about Alterations in neuronal metabolism contribute to the pathogenesis of prion disease.

Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability (2018)
Journal Article

Nitric oxide (NO) regulates neuronal function and thus is critical for tuning neuronal communication. Mechanisms by which NO modulates protein function and interaction include posttranslational modifications (PTMs) such as S-nitrosylation. Importantl... Read More about Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability.