All Outputs (11)

Risk of alcohol-related liver disease in the offspring of parents with alcohol-related liver disease: A nationwide cohort study (2023)
Journal Article
Jepsen, P., West, J., Kann, A. E., Kraglund, F., Morling, J., Crooks, C., & Askgaard, G. (2023). Risk of alcohol-related liver disease in the offspring of parents with alcohol-related liver disease: A nationwide cohort study. Hepatology, https://doi.org/10.1097/hep.0000000000000747

Background and aims: Offspring of patients with alcohol-related liver disease (ALD) may have higher risk of ALD. We examined their risk of ALD and survival with ALD. Approach & Results: We used Danish nationwide registries to identify offspring of... Read More about Risk of alcohol-related liver disease in the offspring of parents with alcohol-related liver disease: A nationwide cohort study.

Pulse oximetry has limited utility in identifying potential patients for long-term oxygen therapy (2023)
Journal Article
Crooks, C. J., West, J., Morling, J. R., Simmonds, M., Juurlink, I., Cruickshank, S., …Fogarty, A. W. (in press). Pulse oximetry has limited utility in identifying potential patients for long-term oxygen therapy. International Journal of Tuberculosis and Lung Disease,

Outcomes after emergency appendicectomy in patients with liver cirrhosis: a population-based cohort study from England (2023)
Journal Article
Adiamah, A., Rashid, A., Crooks, C. J., Hammond, J. S., Jepsen, P., West, J., & Humes, D. J. (2023). Outcomes after emergency appendicectomy in patients with liver cirrhosis: a population-based cohort study from England. Langenbeck's Archives of Surgery, 408, Article 362. https://doi.org/10.1007/s00423-023-03072-3

Introduction The mortality risk after appendicectomy in patients with liver cirrhosis is predicted to be higher than in the general population given the associated risk of perioperative bleeding, infections and liver decompensation. This population-... Read More about Outcomes after emergency appendicectomy in patients with liver cirrhosis: a population-based cohort study from England.

Cause-specific mortality in patients with alcohol-related liver disease in Denmark: a population-based study (2023)
Journal Article
Kann, A. E., Jepsen, P., Madsen, L. G., West, J., & Askgaard, G. (2023). Cause-specific mortality in patients with alcohol-related liver disease in Denmark: a population-based study. Lancet Gastroenterology and Hepatology, 8(11), 1028-1034. https://doi.org/10.1016/S2468-1253%2823%2900192-9

Background Knowledge of the causes of death is essential to prevent premature death in alcohol-related liver disease (ALD). We examined cause-specific mortality, including death due to specific cancers, in 15 years after diagnosis of ALD. Methods... Read More about Cause-specific mortality in patients with alcohol-related liver disease in Denmark: a population-based study.

Understanding colorectal cancer risk for symptomatic patients in primary care: A cohort study utilising faecal immunochemical tests and blood results in England (2023)
Journal Article
Crooks, C. J., Banerjea, A., Jones, J., Chapman, C., Oliver, S., West, J., & Humes, D. J. (2023). Understanding colorectal cancer risk for symptomatic patients in primary care: A cohort study utilising faecal immunochemical tests and blood results in England. Alimentary Pharmacology and Therapeutics, 58(4), 443-452. https://doi.org/10.1111/apt.17632

Background: A faecal immunochemical tests (FIT) cut-off of ≥10 μg Hb/g faeces is now recommended in the UK as a gateway to urgent (suspected cancer) investigation for colorectal cancer (CRC), based on an expected CRC risk threshold of 3%. Aims: To qu... Read More about Understanding colorectal cancer risk for symptomatic patients in primary care: A cohort study utilising faecal immunochemical tests and blood results in England.

Respiratory rate responses to both hypercapnia and acidaemia are modified by age in patients with acidosis (2023)
Journal Article
Crooks, C. J., West, J., Morling, J. R., Simmonds, M., Juurlink, I., Briggs, S., …Fogarty, A. W. (2023). Respiratory rate responses to both hypercapnia and acidaemia are modified by age in patients with acidosis. Respiratory Physiology and Neurobiology, 315, Article 104098. https://doi.org/10.1016/j.resp.2023.104098

Objective To explore the associations between arterial pO2, pCO2 and pH and how these are modified by age. Methods An analysis of 2598 patients admitted with a diagnosis of Covid-19 infection to a large UK teaching hospital. Results There we... Read More about Respiratory rate responses to both hypercapnia and acidaemia are modified by age in patients with acidosis.

Maximal temperature varies by sex and ethnic group in hospital in-patients with Covid-19 infection (2023)
Journal Article
Crooks, C. J., West, J., Gazis, T., Shaw, D., Simmonds, M., Card, T. R., & Fogarty, A. W. (2023). Maximal temperature varies by sex and ethnic group in hospital in-patients with Covid-19 infection. Journal of Medical Virology, 95(6), Article e28837. https://doi.org/10.1002/jmv.28837

Incidence and Survival in Patients With Enteropathy-associated T-Cell Lymphoma: Nationwide Registry Studies From England and Denmark (2023)
Journal Article
West, J., Jepsen, P., Card, T. R., Crooks, C. J., & Bishton, M. (2023). Incidence and Survival in Patients With Enteropathy-associated T-Cell Lymphoma: Nationwide Registry Studies From England and Denmark. Gastroenterology, 165(4), 1064-1066.e3. https://doi.org/10.1053/j.gastro.2023.06.003

1-year survival in haemophagocytic lymphohistiocytosis: a nationwide cohort study from England 2003–2018 (2023)
Journal Article
West, J., Stilwell, P., Liu, H., Ban, L., Bythell, M., Card, T., …Crooks, C. (2023). 1-year survival in haemophagocytic lymphohistiocytosis: a nationwide cohort study from England 2003–2018. Journal of Hematology and Oncology, 16, Article 56. https://doi.org/10.1186/s13045-023-01434-4

Haemophagocytic lymphohistiocytosis (HLH) is a lethal syndrome of excessive immune activation. We undertook a nationwide study in England of all cases of HLH diagnosed between 2003 and 2018, using linked electronic health data from hospital admission... Read More about 1-year survival in haemophagocytic lymphohistiocytosis: a nationwide cohort study from England 2003–2018.

Anaemia of acute inflammation: a higher acute systemic inflammatory response is associated with a larger decrease in blood haemoglobin levels in patients with COVID-19 infection (2023)
Journal Article
Crooks, C. J., West, J., Morling, J. R., Simmonds, M., Juurlink, I., Briggs, S., …Fogarty, A. W. (2023). Anaemia of acute inflammation: a higher acute systemic inflammatory response is associated with a larger decrease in blood haemoglobin levels in patients with COVID-19 infection. Clinical Medicine, 23(3), 201-205. https://doi.org/10.7861/clinmed.2022-0436

AIMS: The study tests the hypothesis that a higher acute systemic inflammatory response was associated with a larger decrease in blood hemoglobin levels in patients with Coronavirus 2019 (COVID-19) infection. METHODS: All patients with either suspect... Read More about Anaemia of acute inflammation: a higher acute systemic inflammatory response is associated with a larger decrease in blood haemoglobin levels in patients with COVID-19 infection.

Effects of statins and aspirin on HCC risk in alcohol-related cirrhosis: nationwide emulated trials (2023)
Journal Article
Kraglund, F., Christensen, D. H., Eiset, A. H., Villadsen, G. E., West, J., & Jepsen, P. (2023). Effects of statins and aspirin on HCC risk in alcohol-related cirrhosis: nationwide emulated trials. Hepatology Communications, 7(1), Article e0013. https://doi.org/10.1097/HC9.0000000000000013

Background and Aims: Observational studies have shown an association between statin or aspirin use and a decreased risk of HCC, but the effects of a well-defined treatment strategy remain unknown. We emulated trials of the effects of continuous stati... Read More about Effects of statins and aspirin on HCC risk in alcohol-related cirrhosis: nationwide emulated trials.