Reduced Ets domain-containing protein Elk1 promotes pulmonary fibrosis via increased integrin ?v?6 expression

Tatler, Amanda L.; Habgood, Anthony; Porte, Joanne; John, Alison E.; Stavrou, Anastasios; Hodge, Emily; Kerama-Likoko, Cheryl; Violette, Shelia M.; Weinreb, Paul H.; Knox, Alan J.; Laurent, Geoffrey; Parfrey, Helen; Wolters, Paul John; Wallace, William; Alberti, Siegfried; Nordheim, Alfred; Jenkins, Gisli

doi:10.1074/jbc.M115.692368

All Outputs (4)

Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33–mediated macrophage polarization and emphysema (2016)
Journal Article

Heterotrimeric guanine nucleotide–binding protein (G protein) signaling is a ubiquitous signaling system that links hundreds of G protein–coupled receptors (GPCRs) with four G protein signaling pathways. Two of these pathways, one mediated by Gq and... Read More about Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33–mediated macrophage polarization and emphysema.

Amplification of TGF? Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis (2016)
Journal Article

© 2016 Tatler et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cre... Read More about Amplification of TGF? Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis.

Secretory leukocyte protease inhibitor gene deletion alters bleomycin-induced lung injury, but not development of pulmonary fibrosis (2016)
Journal Article

Idiopathic pulmonary fibrosis is a progressive, fatal disease with limited treatment options. Protease-mediated transforming growth factor-? (TGF-?) activation has been proposed as a pathogenic mechanism of lung fibrosis. Protease activity in the lun... Read More about Secretory leukocyte protease inhibitor gene deletion alters bleomycin-induced lung injury, but not development of pulmonary fibrosis.

Reduced Ets domain-containing protein Elk1 promotes pulmonary fibrosis via increased integrin ?v?6 expression (2016)
Journal Article

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with high mortality. Active TGF?1 is considered central to the pathogenesis of IPF. A major mechanism of TGF?1 activation in the lung involves the epithelially restricted ?v?6... Read More about Reduced Ets domain-containing protein Elk1 promotes pulmonary fibrosis via increased integrin ?v?6 expression.