Colonisation factor cd0873, an attractive oral vaccine candidate against clostridioides difficile

Karyal, Cansu; Hughes, Jaime; Kelly, Michelle L; Cockayne, Alan; Luckett, Jeni C.; Kaye, Philip V; Minton, Nigel P; Griffin, Ruth

doi:10.3390/microorganisms9020306

All Outputs (3)

Ink-jet 3D printing as a strategy for developing bespoke non-eluting biofilm resistant medical devices (2021)
Journal Article

Chronic infection as a result of bacterial biofilm formation on implanted medical devices is a major global healthcare problem requiring new biocompatible, biofilm-resistant materials. Here we demonstrate how bespoke devices can be manufactured throu... Read More about Ink-jet 3D printing as a strategy for developing bespoke non-eluting biofilm resistant medical devices.

Chemosensitization of temozolomide-resistant pediatric diffuse midline glioma using potent nanoencapsulated forms of a N(3)-propargyl analogue (2021)
Journal Article

The lack of clinical response to the alkylating agent temozolomide (TMZ) in pediatric diffuse midline/intrinsic pontine glioma (DIPG) has been associated with O6-methylguanine-DNA-methyltransferase (MGMT) expression and mismatch repair deficiency. He... Read More about Chemosensitization of temozolomide-resistant pediatric diffuse midline glioma using potent nanoencapsulated forms of a N(3)-propargyl analogue.

Colonisation factor cd0873, an attractive oral vaccine candidate against clostridioides difficile (2021)
Journal Article

Clostridioides difficile is the main cause of health-care-associated infectious diarrhoea. Toxins, TcdA and TcdB, secreted by this bacterium damage colonic epithelial cells and in severe cases this culminates in pseudomembranous colitis, toxic megaco... Read More about Colonisation factor cd0873, an attractive oral vaccine candidate against clostridioides difficile.