Post-modified polypeptides with UCST-type behavior for control of cell attachment in physiological conditions

Xue, Xuan; Thiagarajan, Lalitha; Dixon, James E.; Saunders, Brian R; Shakesheff, Kevin M.; Alexander, Cameron

doi:10.3390/ma11010095

All Outputs (3)

Discovery of peptide ligands targeting a specific ubiquitin-like domain– binding site in the deubiquitinase USP11 (2018)
Journal Article

© 2019 Spiliotopoulos et al. Published by The American Society for Biochemistry and Molecular Biology, Inc. Ubiquitin-specific proteases (USPs) reverse ubiquitination and regulate virtually all cellular processes. Defined noncatalytic domains in USP... Read More about Discovery of peptide ligands targeting a specific ubiquitin-like domain– binding site in the deubiquitinase USP11.

PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy (2018)
Journal Article

The lung remains an attractive target for the gene therapy of monogenetic diseases such as cystic fibrosis (CF). Despite over 27 clinical trials, there are still very few gene therapy vectors that have shown any improvement in lung function; highligh... Read More about PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy.

Post-modified polypeptides with UCST-type behavior for control of cell attachment in physiological conditions (2018)
Journal Article

Upper Critical Solution Temperature (UCST)-type thermally responsive polypeptides (TRPs) with phase transition temperatures around 37 ?C in phosphate-buffered saline (PBS) buffer (pH 7.4, 100 mM) were prepared from poly(L-ornithine) hydrobromide and... Read More about Post-modified polypeptides with UCST-type behavior for control of cell attachment in physiological conditions.