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Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model (2019)
Journal Article
Markides, H., Newell, K. J., Rudorf, H., Ferreras, L. B., Dixon, J. E., Morris, R. H., …El Haj, A. J. (2019). Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model. Stem Cell Research and Therapy, 10, 1-15. doi:10.1186/s13287-018-1123-7

Background Osteochondral injuries represent a significant clinical problem requiring novel cell-based therapies to restore function of the damaged joint with the use of mesenchymal stromal cells (MSCs) leading research efforts. Pre-clinical studies... Read More

PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy (2018)
Journal Article
Osman, G., Rodriguez, J., Chan, S. Y., Chisholm, J., Duncan, G., Kim, N., …Dixon, J. E. (2018). PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy. Journal of Controlled Release, 285, (35-45). doi:10.1016/j.jconrel.2018.07.001. ISSN 0168-3659

The lung remains an attractive target for the gene therapy of monogenetic diseases such as cystic fibrosis (CF). Despite over 27 clinical trials, there are still very few gene therapy vectors that have shown any improvement in lung function; highligh... Read More

Post-modified polypeptides with UCST-type behavior for control of cell attachment in physiological conditions (2018)
Journal Article
Xue, X., Thiagarajan, L., Dixon, J. E., Saunders, B. R., Shakesheff, K. M., & Alexander, C. (2018). Post-modified polypeptides with UCST-type behavior for control of cell attachment in physiological conditions. Materials, 11(1), doi:10.3390/ma11010095. ISSN 1996-1944

Upper Critical Solution Temperature (UCST)-type thermally responsive polypeptides (TRPs) with phase transition temperatures around 37 ◦C in phosphate-buffered saline (PBS) buffer (pH 7.4, 100 mM) were prepared from poly(L-ornithine) hydrobromide and... Read More

Osteogenic programming of human mesenchymal stem cells with highly efficient intracellular delivery of RUNX2 (2017)
Journal Article
Thiagarajan, L., Abu-Awwad, H. A. M., & Dixon, J. E. (2017). Osteogenic programming of human mesenchymal stem cells with highly efficient intracellular delivery of RUNX2. Stem Cells Translational Medicine, 6(12), doi:10.1002/sctm.17-0137. ISSN 2157-6564

Mesenchymal stem cells (MSCs) are being exploited in regenerative medicine due to their tri-lineage differentiation and immunomodulation activity. Currently, there are two major challenges when directing the differentiation of MSCs for therapeutic ap... Read More

Controlled release of GAG-binding enhanced transduction (GET) peptides for sustained and highly efficient intracellular delivery (2017)
Journal Article
Abu-Awwad, H. A. M., Thiagarajan, L., & Dixon, J. E. (2017). Controlled release of GAG-binding enhanced transduction (GET) peptides for sustained and highly efficient intracellular delivery. Acta Biomaterialia, 57, doi:10.1016/j.actbio.2017.04.028. ISSN 1742-7061

Controlled release systems for therapeutic molecules are vital to allow the sustained local delivery of their activities which direct cell behaviour and enable novel regenerative strategies. Direct programming of cells using exogenously delivered tra... Read More

Highly efficient intracellular transduction in three-dimensional gradients for programming cell fate (2016)
Journal Article
Eltaher, H. M., Yang, J., Shakesheff, K. M., & Dixon, J. E. (2016). Highly efficient intracellular transduction in three-dimensional gradients for programming cell fate. Acta Biomaterialia, 41, doi:10.1016/j.actbio.2016.06.004. ISSN 1742-7061

Fundamental behaviour such as cell fate, growth and death are mediated through the control of key genetic transcriptional regulators. These regulators are activated or repressed by the integration of multiple signalling molecules in spatio-temporal g... Read More