All Outputs (2)

Modelling structural and cellular elements and functional responses to lymphatic-delivered cues in a murine lymph node on a chip (2024)
Journal Article
Mazzaglia, C., Munir, H., Man Lei, I., Gerigk, M., Yan Shery Huang, Y., & Shields, J. (2024). Modelling structural and cellular elements and functional responses to lymphatic-delivered cues in a murine lymph node on a chip. Advanced Healthcare Materials, https://doi.org/10.1002/adhm.202303720

Lymph nodes (LNs) are organs of the immune system, critical for maintenance of homeostasis and initiation of immune responses, yet there are few models that accurately recapitulate LN functions in vitro. To tackle this issue, an engineered murine LN... Read More about Modelling structural and cellular elements and functional responses to lymphatic-delivered cues in a murine lymph node on a chip.

Disruption of CD47-SIRPα signaling restores inflammatory function in tumor-associated myeloid-derived suppressor cells (2024)
Journal Article
Zimarino, C., Moody, W., Davidson, S. E., Munir, H., & Shields, J. D. (2024). Disruption of CD47-SIRPα signaling restores inflammatory function in tumor-associated myeloid-derived suppressor cells. iScience, 27(4), Article 109546. https://doi.org/10.1016/j.isci.2024.109546

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous immune population with diverse immunosuppressive functions in solid tumors. Here, we explored the role of the tumor microenvironment in regulating MDSC differentiation and immunosuppressive... Read More about Disruption of CD47-SIRPα signaling restores inflammatory function in tumor-associated myeloid-derived suppressor cells.