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All Outputs (12)

TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation (2014)
Journal Article
Melino, G., Amelio, I., Mak, T. W., Inoue, S., Knight, R. A., Markert, E. K., & Levine, A. J. (2015). TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation. Proceedings of the National Academy of Sciences, 112(1), 226-231. https://doi.org/10.1073/pnas.1410609111

Tumor hypoxia and hypoxia-inducible factor 1 (HIF-1) activation are associated with cancer progression. Here, we demonstrate that the transcription factor TAp73 opposes HIF-1 activity through a nontranscriptional mechanism, thus affecting tumor angio... Read More about TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation.

Bioinformatics analysis of the serine and glycine pathway in cancer cells (2014)
Journal Article
Agostini, M., Antonov, A., Morello, M., Minieri, M., Melino, G., & Amelio, I. (2014). Bioinformatics analysis of the serine and glycine pathway in cancer cells. Oncotarget, 5(22), 11004-11013. https://doi.org/10.18632/oncotarget.2668

Serine and glycine are amino acids that provide the essential precursors for the synthesis of proteins, nucleic acids and lipids. Employing 3 subsequent enzymes, phosphoglycerate dehydrogenase (PHGDH), phosphoserine phosphatase (PSPH), phosphoserine... Read More about Bioinformatics analysis of the serine and glycine pathway in cancer cells.

TAp73 promotes anabolism (2014)
Journal Article
Amelio, I., Antonov, A. A., Catani, M. V., Massoud, R., Bernassola, F., Knight, R. A., …Rufini, A. (2014). TAp73 promotes anabolism. Oncotarget, 5(24), 12820-12834. https://doi.org/10.18632/oncotarget.2667

Metabolic adaptation has emerged as a hallmark of cancer and a promising therapeutic target, as rapidly proliferating cancer cells adapt their metabolism increasing nutrient uptake and reorganizing metabolic fluxes to support biosynthesis. The transc... Read More about TAp73 promotes anabolism.

MicroRNAs and p63 in epithelial stemness (2014)
Journal Article
Candi, E., Amelio, I., Agostini, M., & Melino, G. (2015). MicroRNAs and p63 in epithelial stemness. Cell Death and Differentiation, 22(1), 12-21. https://doi.org/10.1038/cdd.2014.113

MicroRNAs (miRs) are a class of small noncoding RNAs that suppress the expression of protein-coding genes by repressing protein translation. Although the roles that miRs and the miR processing machinery have in regulating epithelial stem cell biology... Read More about MicroRNAs and p63 in epithelial stemness.

Metabolic effect of TAp63? enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense (2014)
Journal Article
D’Alessandro, A., Amelio, I., Berkers, C. R., Antonov, A., Vousden, K. H., Melino, G., & Zolla, L. (2014). Metabolic effect of TAp63α enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense. Oncotarget, 5(17), 7722-7733. https://doi.org/10.18632/oncotarget.2300

TAp63? is a member of the p53 family, which plays a central role in epithelial cancers. Recently, a role has emerged for p53 family members in cancer metabolic modulation. In order to assess whether TAp63? plays a role in cancer metabolism, we exp... Read More about Metabolic effect of TAp63? enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense.

High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy (2014)
Journal Article
Amelio, I., Rossi, M., Rotblat, B., Ansell, K., Cavasotto, C. N., Caraglia, M., …Melino, G. (2014). High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy. Cell Death and Disease, 5(5), Article e1203. https://doi.org/10.1038/cddis.2014.113

Inhibition of distinct ubiquitin E3 ligases might represent a powerful therapeutic tool. ITCH is a HECT domain-containing E3 ligase that promotes the ubiquitylation and degradation of several proteins, including p73, p63, c-Jun, JunB, Notch and c-FLI... Read More about High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy.

p63 transcriptionally regulates the expression of matrix metallopeptidase 13 (2014)
Journal Article
Celardo, I., Antonov, A., Amelio, I., Annicchiarico-Petruzzelli, M., & Melino, G. (2014). p63 transcriptionally regulates the expression of matrix metallopeptidase 13. Oncotarget, 5(5), 1279-1289. https://doi.org/10.18632/oncotarget.1778

p63 is a transcriptional factor belonging to p53 family of genes. Beside the role in cancer, partially shared with p53 and the other member p73, p63 also plays exclusive roles in development and homeostasis of ectodermal/epidermal-related organs. Her... Read More about p63 transcriptionally regulates the expression of matrix metallopeptidase 13.

TAp73 is required for spermatogenesis and the maintenance of male fertility (2014)
Journal Article
Inoue, S., Tomasini, R., Rufini, A., Elia, A. J., Agostini, M., Amelio, I., …Mak, T. W. (2014). TAp73 is required for spermatogenesis and the maintenance of male fertility. Proceedings of the National Academy of Sciences, 111(5), 1843-1848. https://doi.org/10.1073/pnas.1323416111

The generation of viable sperm proceeds through a series of coordinated steps, including germ cell self-renewal, meiotic recombination, and terminal differentiation into functional spermatozoa. The p53 family of transcription factors, including p53,... Read More about TAp73 is required for spermatogenesis and the maintenance of male fertility.