All Outputs (4)

The C terminus of p73 is essential for hippocampal development (2020)
Journal Article
Morone, N., Amelio, I., Panatta, E., Niklison-Chirou, M. V., Steinert, J. R., Agostini, M., …Knight, R. A. (2020). The C terminus of p73 is essential for hippocampal development. Proceedings of the National Academy of Sciences, 117(27), 15694-15701. https://doi.org/10.1073/pnas.2000917117

The p53 family member p73 has a complex gene structure, including alternative promoters and alternative splicing of the 3′ UTR. This results in a complex range of isoforms whose biological relevance largely remains to be determined. By deleting exon... Read More about The C terminus of p73 is essential for hippocampal development.

ZNF750 represses breast cancer invasion via epigenetic control of prometastatic genes (2020)
Journal Article
Cassandri, M., Butera, A., Amelio, I., Lena, A. M., Montanaro, M., Mauriello, A., …Melino, G. (2020). ZNF750 represses breast cancer invasion via epigenetic control of prometastatic genes. Oncogene, 39(22), 4331-4343. https://doi.org/10.1038/s41388-020-1277-5

Context is everything: extrinsic signalling and gain-of-function p53 mutants (2020)
Journal Article
Amelio, I., & Melino, G. (2020). Context is everything: extrinsic signalling and gain-of-function p53 mutants. Cell Death Discovery, 6, Article 16. https://doi.org/10.1038/s41420-020-0251-x

The TP53 genomic locus is a target of mutational events in at least half of cancers. Despite several decades of study, a full consensus on the relevance of the acquisition of p53 gain-of-function missense mutants has not been reached. Depending on ca... Read More about Context is everything: extrinsic signalling and gain-of-function p53 mutants.

Glutathione–Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair (2020)
Journal Article
Di Giovanni, E., Buonvino, S., Amelio, I., & Melino, S. (2020). Glutathione–Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair. International Journal of Molecular Sciences, 21(5), Article 1638. https://doi.org/10.3390/ijms21051638

The endogenous gasotransmitter H2S plays an important role in the central nervous, respiratory and cardiovascular systems. Accordingly, slow-releasing H2S donors are powerful tools for basic studies and innovative pharmaco-therapeutic agents for card... Read More about Glutathione–Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair.