TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation
(2014)
Journal Article
Melino, G., Amelio, I., Mak, T. W., Inoue, S., Knight, R. A., Markert, E. K., & Levine, A. J. (2015). TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation. Proceedings of the National Academy of Sciences, 112(1), 226-231. https://doi.org/10.1073/pnas.1410609111
Tumor hypoxia and hypoxia-inducible factor 1 (HIF-1) activation are associated with cancer progression. Here, we demonstrate that the transcription factor TAp73 opposes HIF-1 activity through a nontranscriptional mechanism, thus affecting tumor angio... Read More about TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation.