Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi

Mikolajek, Halina; Sanchez-Weatherby, Juan; Sandy, James; Gildea, Richard J.; Campeotto, Ivan; Cheruvara, Harish; Clarke, John D.; Foster, Toshana; Fujii, Sotaro; Paulsen, Ian T.; Shah, Bhumika S.; Hough, Michael A.

doi:10.1107/s2052252523003810

All Outputs (3)

The Potential of Plant-Produced Virus-like Particle Vaccines for African Horse Sickness and Other Equine Orbiviruses (2024)
Journal Article

African horse sickness is a devastating viral disease of equids. It is transmitted by biting midges of the genus Culicoides with mortalities reaching over 90% in naïve horses. It is endemic to sub-Saharan Africa and is seasonally endemic in many part... Read More about The Potential of Plant-Produced Virus-like Particle Vaccines for African Horse Sickness and Other Equine Orbiviruses.

Open and closed conformations of a sub-80 kDa Chagas vaccine candidate defined by a cryo-EM led integrative approach (2024)
Working Paper

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, remains a significant global public health concern. It affects an estimated eight million individuals worldwide, with the majority remaining undiagnosed. Despite its profound health... Read More about Open and closed conformations of a sub-80 kDa Chagas vaccine candidate defined by a cryo-EM led integrative approach.

Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi (2023)
Journal Article

The utility of X-ray crystal structures determined under ambient-temperature conditions is becoming increasingly recognized. Such experiments can allow protein dynamics to be characterized and are particularly well suited to challenging protein targe... Read More about Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi.