All Outputs (2)

Functional modulation of PTH1R activation and signaling by RAMP2 (2022)
Journal Article
Nemec, K., Schihada, H., Kleinau, G., Zabel, U., Grushevskyi, E. O., Scheerer, P., …Maiellaro, I. (2022). Functional modulation of PTH1R activation and signaling by RAMP2. Proceedings of the National Academy of Sciences, 119(32), Article e2122037119. https://doi.org/10.1073/pnas.2122037119

Receptor-activity-modifying proteins (RAMPs) are ubiquitously expressed membrane proteins that associate with different G protein-coupled receptors (GPCRs), including the parathyroid hormone 1 receptor (PTH1R), a class B GPCR and an important modulat... Read More about Functional modulation of PTH1R activation and signaling by RAMP2.

Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling (2022)
Journal Article
Anton, S. E., Kayser, C., Maiellaro, I., Nemec, K., Möller, J., Koschinski, A., …Bock, A. (2022). Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling. Cell, 185(7), 1130-1142.e11. https://doi.org/10.1016/j.cell.2022.02.011

G protein-coupled receptors (GPCRs) relay extracellular stimuli into specific cellular functions. Cells express many different GPCRs, but all these GPCRs signal to only a few second messengers such as cAMP. It is largely unknown how cells distinguish... Read More about Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling.