All Outputs (6)

Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor (2014)
Journal Article
Wall, R. J., Fernades, A., Rose, M., Bell, D. R., & Mellor, I. R. (2015). Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor. Environment International, 76, 49-56. https://doi.org/10.1016/j.envint.2014.12.002

The Aryl hydrocarbon receptor (AhR) binds a variety of chlorinated and brominated dioxins, furans and biphenyls. Mixed halogenated variants have been recently identified in food at significant levels but full characterisation requires potency data in... Read More about Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor.

Two-directional synthesis and biological evaluation of alkaloid 5-epi-cis-275B? (2014)
Journal Article
Procopiou, G., Aggarwal, P., Newton, A. F., Richards, D., Mellor, I. R., Harbottle, G., & Stockman, R. A. (2014). Two-directional synthesis and biological evaluation of alkaloid 5-epi-cis-275B?. Chemical Communications, 50(97), 15355-15357. https://doi.org/10.1039/c4cc07287a

© 2014 The Royal Society of Chemistry. The first total synthesis of myrmicine ant alkaloid 5-epi-cis-275B′ (4) is presented. A tandem cyclisation established the entire core of the structure in a single transformation as well as the required 2,5-anti... Read More about Two-directional synthesis and biological evaluation of alkaloid 5-epi-cis-275B?.

The Effects of Conformational Constraints in the Polyamine Moiety of Philanthotoxins on AMPAR Inhibition (2014)
Journal Article
Franzyk, H., Grzeskowiak, J. W., Tikhonov, D. B., Jaroszewski, J. W., & Mellor, I. R. (2014). The Effects of Conformational Constraints in the Polyamine Moiety of Philanthotoxins on AMPAR Inhibition. ChemMedChem, 9(8), 1725-1731. https://doi.org/10.1002/cmdc.201402109

Philanthotoxin?433 (PhTX?433) is a known potent inhibitor of ionotropic glutamate receptors, and analogues have been synthesised to identify more potent and selective antagonists. Herein we report the synthesis of four PhTXs with a cyclopropane moiet... Read More about The Effects of Conformational Constraints in the Polyamine Moiety of Philanthotoxins on AMPAR Inhibition.

Erratum: Genes involved in the induction of liver growth by peroxisome proliferators (Toxicol. Res. (2014) DOI: 10.1039/c3tx50110h) (2014)
Journal Article
Amer, A. H., Wall, R. J., Malla, S., Aboobaker, A., Sang, F., Avery, S. V., …Bell, D. R. (2014). Erratum: Genes involved in the induction of liver growth by peroxisome proliferators (Toxicol. Res. (2014) DOI: 10.1039/c3tx50110h). Toxicology Research, 3(5), 401. https://doi.org/10.1039/C4TX90012J

The authors would like to add an additional acknowledgement as follows: We wish to acknowledge Fikry Abushofa for technical assistance.

Genes involved in the induction of liver growth by peroxisome proliferators (2014)
Journal Article
Amer, A. H., Wall, R. J., Malla, S., Sang, F., Aboobaker, A., Avery, S. V., …Bell, D. R. (2014). Genes involved in the induction of liver growth by peroxisome proliferators. Toxicology Research, 3(5), 315-323. https://doi.org/10.1039/c3tx50110h

The mechanisms regulating the induction of hepatic DNA synthesis by PPARα agonists are currently incompletely understood, and we set out to determine whether there are different mechanisms of induction for PPARα agonists and other hepatic growth agen... Read More about Genes involved in the induction of liver growth by peroxisome proliferators.

The antimalarial drug quinine interferes with serotonin biosynthesis and action (2014)
Journal Article
Islahudin, F., Tindall, S. M., Mellor, I. R., Swift, K., Christensen, H. E., Fone, K. C., …Avery, S. V. (2014). The antimalarial drug quinine interferes with serotonin biosynthesis and action. Scientific Reports, 4(3618), https://doi.org/10.1038/srep03618

The major antimalarial drug quinine perturbs uptake of the essential amino acid tryptophan, and patients with low plasma tryptophan are predisposed to adverse quinine reactions; symptoms of which are similar to indications of tryptophan depletion. As... Read More about The antimalarial drug quinine interferes with serotonin biosynthesis and action.