Clinicopathological significance of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in oestrogen-receptor-positive breast cancer

Abdel-Fatah, Tarek M. A.; Perry, Christina; Moseley, Paul; Johnson, Kerstie; Arora, Arvind; Chan, Stephen; Ellis, Ian O.; Madhusudan, Srinivasan

doi:10.1007/s10549-013-2820-7

All Outputs (42)

DACH1: Its Role as a Classifier of Long Term Good Prognosis in Luminal Breast Cancer (2014)
Journal Article
Powe, D. G., Dhondalay, G. K. R., Lemetre, C., Allen, T., Habashy, H. O., Ellis, I. O., …Ball, G. R. (2014). DACH1: Its Role as a Classifier of Long Term Good Prognosis in Luminal Breast Cancer. PLoS ONE, 9(1), e84428. https://doi.org/10.1371/journal.pone.0084428

Clinicopathological significance of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in oestrogen-receptor-positive breast cancer (2014)
Journal Article
Abdel-Fatah, T. M. A., Perry, C., Moseley, P., Johnson, K., Arora, A., Chan, S., …Madhusudan, S. (2014). Clinicopathological significance of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in oestrogen-receptor-positive breast cancer. Breast Cancer Research and Treatment, 143(3), 411-421. https://doi.org/10.1007/s10549-013-2820-7

Oestrogen metabolites can induce oxidative DNA base damage and generate potentially mutagenic apurinic sites (AP sites) in the genomic DNA. If unrepaired, mutagenic AP sites could drive breast cancer pathogenesis and aggressive phenotypes. Human apur... Read More about Clinicopathological significance of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in oestrogen-receptor-positive breast cancer.