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Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 1: Developing and delivering high-quality independent clinical trials (2022)
Journal Article
Williams, H. C., McPhee, M., Layfield, C., & The UK Dermatology Clinical Trials Network. (2022). Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 1: Developing and delivering high-quality independent clinical trials. Clinical and Experimental Dermatology, 47(6), 1048-1059. https://doi.org/10.1111/ced.15140

The UK Dermatology Clinical Trials Network (UK DCTN) was formed in 2002 with the aim of developing and supporting high-quality independent national clinical trials that address prioritized research questions for people with skin disease. Its philosop... Read More about Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 1: Developing and delivering high-quality independent clinical trials.

Response to ‘The role of curettage as an intervention for basal cell carcinoma’. Re. ‘Interventions for basal cell carcinoma: abridged Cochrane systematic review and GRADE assessments’: reply from the authors (2021)
Journal Article
Bath-Hextall, F. J., Thomson, J., Hogan, S., Leonardi-Bee, J., Williams, H. C., & Bath‐Hextall, F. (2022). Response to ‘The role of curettage as an intervention for basal cell carcinoma’. Re. ‘Interventions for basal cell carcinoma: abridged Cochrane systematic review and GRADE assessments’: reply from the authors. British Journal of Dermatology, 186(4), 751-752. https://doi.org/10.1111/bjd.20950

Clinical examination for hyperlinear palms to determine filaggrin genotype: A diagnostic test accuracy study (2021)
Journal Article
Bradshaw, L. E., Haines, R. H., Thomas, K. S., Chalmers, J. R., Irvine, A. D., Williams, H. C., & Brown, S. J. (2021). Clinical examination for hyperlinear palms to determine filaggrin genotype: A diagnostic test accuracy study. Clinical and Experimental Allergy, 51(11), 1421-1428. https://doi.org/10.1111/cea.14025

Background: Palmar hyperlinearity is a feature of ichthyosis vulgaris, the monogenic skin disorder caused by FLG loss-of-function mutations. Objective: To investigate how well the presence or absence of hyperlinear palms (HLP) detect FLG genotype in... Read More about Clinical examination for hyperlinear palms to determine filaggrin genotype: A diagnostic test accuracy study.

Safety of topical corticosteroids in atopic eczema: an umbrella review (2021)
Journal Article
Axon, E., Chalmers, J. R., Santer, M., Ridd, M. J., Lawton, S., Langan, S. M., Grindlay, D. J., Muller, I., Roberts, A., Ahmed, A., Williams, H. C., & Thomas, K. S. (2021). Safety of topical corticosteroids in atopic eczema: an umbrella review. BMJ Open, 11(7), Article e046476. https://doi.org/10.1136/bmjopen-2020-046476

Objective An umbrella review summarising all safety data from systematic reviews of topical corticosteroids (TCS) in adults and children with atopic eczema. Methods Embase, MEDLINE, PubMed, Cochrane Database of Systematic Reviews and the Centre of Ev... Read More about Safety of topical corticosteroids in atopic eczema: an umbrella review.

Realising the full potential of data-enabled trials in the UK: a call for action (2021)
Journal Article
Sydes, M. R., Barbachano, Y., Bowman, L., Denwood, T., Farmer, A., Garfield-Birkbeck, S., Gibson, M., Gulliford, M. C., Harrison, D. A., Hewitt, C., Logue, J., Navaie, W., Norrie, J., O’Kane, M., Quint, J. K., Rycroft-Malone, J., Sheffield, J., Smeeth, L., Sullivan, F., Tizzard, J., …Valentine, J. (2021). Realising the full potential of data-enabled trials in the UK: a call for action. BMJ Open, 11(6), 1-15. https://doi.org/10.1136/bmjopen-2020-043906

Rationale: Clinical trials are the gold standard for testing interventions. COVID-19 has further raised their public profile, and emphasised the need to deliver better, faster, more efficient trials for patient benefit. Considerable overlap exists be... Read More about Realising the full potential of data-enabled trials in the UK: a call for action.

Faculty Opinions Recommendation of [Scher JU and Schett G, Nat Rev Rheumatol 2021 17(2):119-124] (2021)
Other
Williams, H. (2021). Faculty Opinions Recommendation of [Scher JU and Schett G, Nat Rev Rheumatol 2021 17(2):119-124]

This is the best article I have ever read on the phenomenon of key opinion leaders (KOLs) – senior influencers who are paid by the pharmaceutical industry to influence prescribing by clinicians at meetings and through writing. The depth of analysis a... Read More about Faculty Opinions Recommendation of [Scher JU and Schett G, Nat Rev Rheumatol 2021 17(2):119-124].

Evidence-based management of eczema: five things that should be done more and five things that should be dropped (2021)
Journal Article
Olabi, B., & Williams, H. C. (2021). Evidence-based management of eczema: five things that should be done more and five things that should be dropped. Current Opinion in Allergy and Clinical Immunology, 21(4), 386-393. https://doi.org/10.1097/ACI.0000000000000750

Purpose of review

We provide readers with an evidence-informed opinion on current treatments for eczema (atopic dermatitis) with the intention of improving patient care. We suggest five treatment aspects that should be promoted and five that shou... Read More about Evidence-based management of eczema: five things that should be done more and five things that should be dropped.

Developing the INCLUDE Ethnicity Framework—a tool to help trialists design trials that better reflect the communities they serve (2021)
Journal Article
Treweek, S., Banister, K., Bower, P., Cotton, S., Devane, D., Gardner, H. R., Isaacs, T., Nestor, G., Oshisanya, A., Parker, A., Rochester, L., Soulsby, I., Williams, H., & Witham, M. D. (2021). Developing the INCLUDE Ethnicity Framework—a tool to help trialists design trials that better reflect the communities they serve. Trials, 22(1), Article 337. https://doi.org/10.1186/s13063-021-05276-8

Background

Ensuring that a trial is designed so that its participants reflect those who might benefit from the results, or be spared harms, is key to the potential benefits of the trial reaching all they should. This paper describes the process, f... Read More about Developing the INCLUDE Ethnicity Framework—a tool to help trialists design trials that better reflect the communities they serve.

Interventions for basal cell carcinoma: abridged Cochrane systematic review and grade assessments (2021)
Journal Article
Thomson, J., Hogan, S., Leonardi‐Bee, J., Williams, H., & Bath‐Hextall, F. (2021). Interventions for basal cell carcinoma: abridged Cochrane systematic review and grade assessments. British Journal of Dermatology, 185(3), 499-511. https://doi.org/10.1111/bjd.19809

Background
Basal cell carcinoma (BCC) is the commonest cancer affecting white‐skinned individuals, and worldwide incidence is increasing. Although rarely fatal, BCC is associated with significant morbidity and costs.

Objectives
To assess the eff... Read More about Interventions for basal cell carcinoma: abridged Cochrane systematic review and grade assessments.

Can atopic eczema and psoriasis coexist? A systematic review and meta‐analysis (2021)
Journal Article
Cunliffe, A., Gran, S., Ali, U., Grindlay, D., Lax, S., Williams, H., & Burden-Teh, E. (2021). Can atopic eczema and psoriasis coexist? A systematic review and meta‐analysis. Skin Health and Disease, 1(2), Article e29. https://doi.org/10.1002/ski2.29

Importance: Previous studies report both co-existence and mutual exclusivity of atopic eczema (AE) and psoriasis, but these have not been appraised systematically. Knowledge of such disease association throws light on disease mechanisms and may influ... Read More about Can atopic eczema and psoriasis coexist? A systematic review and meta‐analysis.

Clinical integration of fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma (2021)
Journal Article
Boitor, R., de Wolf, C., Weesie, F., Shipp, D. W., Varma, S., Veitch, D., Wernham, A., Koloydenko, A., Puppels, G., Nijsten, T., Williams, H. C., Caspers, P., & Notingher, I. (2021). Clinical integration of fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma. Biomedical Optics Express, 12(4), 2015-2026. https://doi.org/10.1364/boe.417896

We present the first clinical integration of a prototype device based on integrated auto-fluorescence imaging and Raman spectroscopy (Fast Raman device) for intra-operative assessment of surgical margins during Mohs micrographic surgery of basal cell... Read More about Clinical integration of fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma.

Association of frequent moisturizer use in early infancy with the development of food allergy (2021)
Journal Article
Perkin, M. R., Logan, K., Marrs, T., Radulovic, S., Craven, J., Boyle, R. J., Chalmers, J. R., Williams, H. C., Versteeg, S. A., Van Ree, R., Lack, G., & Flohr, C. (2021). Association of frequent moisturizer use in early infancy with the development of food allergy. Journal of Allergy and Clinical Immunology, 147(3), 967-976.e1. https://doi.org/10.1016/j.jaci.2020.10.044

Background
Food allergy is thought to develop through transcutaneous sensitization, especially in the presence of skin barrier impairment and inflammation. Regular moisturizer application to infant skin could potentially promote transcutaneous sensi... Read More about Association of frequent moisturizer use in early infancy with the development of food allergy.

Skin care interventions in infants for preventing eczema and food allergy: a Cochrane systematic review and individual participant data meta‐analysis (2021)
Journal Article
Kelleher, M. M., Cro, S., Van Vogt, E., Cornelius, V., Lodrup Carlsen, K. C., Skjerven, H. O., Rehbinder, E. M., Lowe, A., Dissanayake, E., Shimojo, N., Yonezawa, K., Ohya, Y., Yamamoto‐Hanada, K., Morita, K., Cork, M., Cooke, A., Simpson, E. L., McClanahan, D., Weidinger, S., Schmitt, J., …Boyle, R. J. (2021). Skin care interventions in infants for preventing eczema and food allergy: a Cochrane systematic review and individual participant data meta‐analysis. Clinical and Experimental Allergy, 51(3), 402-418. https://doi.org/10.1111/cea.13847

Skin care interventions in infants for preventing eczema and food allergy (2021)
Journal Article
Kelleher, M. M., Cro, S., Cornelius, V., Lodrup Carlsen, K. C., Skjerven, H. O., Rehbinder, E. M., Lowe, A. J., Dissanayake, E., Shimojo, N., Yonezawa, K., Ohya, Y., Yamamoto-Hanada, K., Morita, K., Axon, E., Surber, C., Cork, M., Cooke, A., Tran, L., Van Vogt, E., Schmitt, J., …Boyle, R. J. (2021). Skin care interventions in infants for preventing eczema and food allergy. Cochrane Library, 2021(2), Article CD013534. https://doi.org/10.1002/14651858.cd013534.pub2

Background

Eczema and food allergy are common health conditions that usually begin in early childhood and often occur together in the same people. They can be associated with an impaired skin barrier in early infancy. It is unclear whether trying... Read More about Skin care interventions in infants for preventing eczema and food allergy.

Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers (2021)
Journal Article
Muller, I., Stuart, B., Sach, T., Hooper, J., Wilczynska, S., Steele, M., Greenwell, K., Sivyer, K., Yardley, L., Williams, H. C., Chalmers, J. R., Leighton, P., Howells, L. M., Ridd, M. J., Lawton, S., Griffiths, G., Nuttall, J., Langan, S. M., Roberts, A., Ahmed, A., …Santer, M. (2021). Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers. BMJ Open, 11(2), Article e045583. https://doi.org/10.1136/bmjopen-2020-045583

Introduction Eczema care requires management of triggers and various treatments. We developed two online behavioural interventions to support eczema care called ECO (Eczema Care Online) for young people and ECO for families. This protocol describes t... Read More about Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers.

Recommended core outcome instruments for health‐related quality of life, long‐term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting (2021)
Journal Article
Thomas, K., Apfelbacher, C., Chalmers, J., Simpson, E., Spuls, P., Gerbens, L., Williams, H., Schmitt, J., Gabes, M., Howells, L., Stuart, B., Grinich, E., Pawlitschek, T., Burton, T., Howie, L., Gadkari, A., Eckert, L., Ebata, T., Boers, M., Saeki, H., …Katoh, N. (2021). Recommended core outcome instruments for health‐related quality of life, long‐term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting. British Journal of Dermatology, 185(1), 139-146. https://doi.org/10.1111/bjd.19751

Background: The Harmonising Outcome Measures for Eczema (HOME) initiative has established a core outcome set of domains for atopic eczema (AE) clinical trials. Previous consensus meetings have agreed on preferred instruments for clinician-reported si... Read More about Recommended core outcome instruments for health‐related quality of life, long‐term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting.

Scoping the international impact from four independent national dermatology trials (2020)
Journal Article
Williams, H. C., Rogers, N. K., Chalmers, J. R., & Thomas, K. S. (2021). Scoping the international impact from four independent national dermatology trials. Clinical and Experimental Dermatology, 46(4), 657-662. https://doi.org/10.1111/ced.14506

Background: Research impact describes whether and how research results in wider benefits to society beyond academic publication. Little is known about translation of clinical trial research into dermatological practice. Aim: We scoped international i... Read More about Scoping the international impact from four independent national dermatology trials.