All Outputs (21)
Measuring Atopic Eczema Control and Itch Intensity in Clinical Practice: A Consensus Statement from the Harmonising Outcome Measures for Eczema in Clinical Practice (HOME-CP) Initiative (2022)
Journal Article
Importance: Measuring outcomes in clinical practice can aid patient care, quality improvement, and real-world evidence generation. The Harmonising Outcome Measures for Eczema (HOME) Clinical Practice initiative is developing a list of validated, feas... Read More about Measuring Atopic Eczema Control and Itch Intensity in Clinical Practice: A Consensus Statement from the Harmonising Outcome Measures for Eczema in Clinical Practice (HOME-CP) Initiative.
Is routine laboratory testing in healthy young patients taking isotretinoin necessary – a critically appraised topic (2022)
Journal Article
Clinical question: Is monitoring of liver function, lipids and full blood count necessary in healthy people taking isotretinoin? Background: Routine blood testing was recommended in the original licence for Roaccutane™ (isotretinoin) in 1983. In r... Read More about Is routine laboratory testing in healthy young patients taking isotretinoin necessary – a critically appraised topic.
Background: Immunosuppressive treatments inhibit vaccine-induced immunity against SARS-CoV-2. We evaluated whether a 2-week interruption of methotrexate treatment immediately after the COVID-19 vaccine booster improved antibody responses against the... Read More about Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial.
On the definition of dermatological disease. Part 1: conceptual frameworks (2022)
Journal Article
Little attention is paid to disease definition in dermatology and how such definitions come about, yet defining a disease is a fundamental step upon which all subsequent clinical management and prognostic judgements depend. Developing diagnostic crit... Read More about On the definition of dermatological disease. Part 1: conceptual frameworks.
Artificial intelligence and machine learning algorithms for early detection of skin cancer in community and primary care settings: a systematic review (2022)
Journal Article
Skin cancers occur commonly worldwide. The prognosis and disease burden are highly dependent on the cancer type and disease stage at diagnosis. We systematically reviewed studies on artificial intelligence and machine learning (AI/ML) algorithms that... Read More about Artificial intelligence and machine learning algorithms for early detection of skin cancer in community and primary care settings: a systematic review.
Effectiveness and safety of lotion, cream, gel, and ointment emollients for childhood eczema: a pragmatic, randomised, phase 4, superiority trial (2022)
Journal Article
Background: To our knowledge, there are no trials comparing emollients commonly used for childhood eczema. We aimed to compare the clinical effectiveness and safety of the four main emollient types: lotions, creams, gels, and ointments. Methods: We d... Read More about Effectiveness and safety of lotion, cream, gel, and ointment emollients for childhood eczema: a pragmatic, randomised, phase 4, superiority trial.
Incidence and pattern of mycophenolate discontinuation associated with abnormal monitoring blood-test results: cohort study using data from the Clinical Practice Research Datalink Aurum (2022)
Journal Article
Objective: The aim was to examine the incidence and pattern of MMF discontinuation associated with abnormal monitoring blood-test results. Methods: Data from people prescribed MMF for common inflammatory conditions in the Clinical Practice Research D... Read More about Incidence and pattern of mycophenolate discontinuation associated with abnormal monitoring blood-test results: cohort study using data from the Clinical Practice Research Datalink Aurum.
Introduction It is unknown if a temporary break in long-term immune-suppressive treatment after vaccination against COVID-19 improves vaccine response. The objective of this study was to evaluate if a 2-week interruption in low-dose weekly methotrexa... Read More about Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off Methotrexate (VROOM) study).
Eczema Care Online: development and qualitative optimisation of an online behavioural intervention to support self-management in young people with eczema (2022)
Journal Article
Objectives To describe the development of Eczema Care Online (ECO), an online behaviour change intervention for young people with eczema (phase I); and explore and optimise the acceptability of ECO among this target group using think-aloud interviews... Read More about Eczema Care Online: development and qualitative optimisation of an online behavioural intervention to support self-management in young people with eczema.
Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 2: education, training and capacity building (2022)
Journal Article
In Part 1 of this 2-part review of the 20th anniversary of the UK Dermatology Clinical Trials Network (UK DCTN), we described its role in developing and supporting clinical trial proposals, elaborating on structure, process and clinical trials activi... Read More about Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 2: education, training and capacity building.
Avoidable research waste in dermatology: what are the solutions? (2022)
Journal Article
In the last editorial, I provided examples of research waste in dermatology and suggested that it was due to a system failure rather than just a few “bad apples”. Here, I focus on possible solutions, mainly in relation to clinical trials, building on... Read More about Avoidable research waste in dermatology: what are the solutions?.
Avoidable research waste in dermatology: what are the solutions? (2022)
Journal Article
In the last editorial, I provided examples of research waste in dermatology and suggested that it was due to a system failure rather than just a few “bad apples”. Here, I focus on possible solutions, mainly in relation to clinical trials, building on... Read More about Avoidable research waste in dermatology: what are the solutions?.
The HOME Core outcome set for clinical trials of atopic dermatitis (2022)
Journal Article
Core outcome sets are critically important outcomes that should be measured in clinical trials. Their absence in atopic dermatitis is a form of research waste and impedes combining evidence to inform patient care. Here, we articulate the rationale fo... Read More about The HOME Core outcome set for clinical trials of atopic dermatitis.
Avoidable research waste in dermatology: what is the problem? (2022)
Journal Article
Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics (2022)
Journal Article
Atopic dermatitis is a heterogeneous disease, accompanied by a wide variation in disease presentation and the potential to identify many phenotypes that may be relevant for prognosis and treatment. We aimed to systematically review previously reporte... Read More about Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics.
Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 1: Developing and delivering high-quality independent clinical trials (2022)
Journal Article
The UK Dermatology Clinical Trials Network (UK DCTN) was formed in 2002 with the aim of developing and supporting high-quality independent national clinical trials that address prioritized research questions for people with skin disease. Its philosop... Read More about Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 1: Developing and delivering high-quality independent clinical trials.
Burns with emollients (2022)
Journal Article