All Outputs (5)

Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders (2023)
Journal Article

The study of modified RNA known as epitranscriptomics has become increasingly relevant in our understanding of disease-modifying mechanisms. Methylation of N6 adenosine (m 6 A) and C5 cytosine (m 5 C) bases occur on mRNAs, tRNA, mt-tRNA, and rRNA spe... Read More about Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders.

Extracellular vesicle microRNA mediated transcriptional regulation may contribute to Dementia with Lewy Bodies molecular pathology (2023)
Journal Article

Objective: Dementia with Lewy bodies (DLB) is the second most common dementia. Advancing our limited understanding of its molecular pathogenesis is essential for identifying novel biomarkers and therapeutic targets for DLB. DLB is an α-synucleinop... Read More about Extracellular vesicle microRNA mediated transcriptional regulation may contribute to Dementia with Lewy Bodies molecular pathology.

m6A mRNA methylation in human brain is disrupted in Lewy body disorders (2023)
Journal Article

N6-methyladenosine modification of RNA (m6A) regulates translational control which may influence neuronal dysfunction underlying neurodegenerative diseases. Using microscopy and a machine learning approach, we performed cellular profiling of m6A-RNA... Read More about m6A mRNA methylation in human brain is disrupted in Lewy body disorders.

The importance of m6A topology in chicken embryo mRNA: a precise mapping of m6A at the conserved chicken β-actin zipcode (2023)
Journal Article

N6-methyladenosine (m6A) in mRNA regulates almost every stage in the mRNA life cycle, and the development of methodologies for the high-throughput detection of methylated sites in mRNA using m6A-specific methylated RNA immunoprecipitation with next-g... Read More about The importance of m6A topology in chicken embryo mRNA: a precise mapping of m6A at the conserved chicken β-actin zipcode.

Differential expression of m5C RNA methyltransferase genes NSUN6 and NSUN7 in Alzheimer’s disease and traumatic brain injury (2023)
Journal Article

Epigenetic processes have become increasingly relevant in understanding disease-modifying mechanisms. 5-Methylcytosine methylations of DNA (5mC) and RNA (m5C) have functional transcriptional and RNA translational consequences and are tightly regulate... Read More about Differential expression of m5C RNA methyltransferase genes NSUN6 and NSUN7 in Alzheimer’s disease and traumatic brain injury.