Interaction of nutrition and genetics via DNMT3L-mediated DNA methylation determines cognitive decline

Flitton, Miles; Rielly, Nicholas; Warman, Rhian; Warden, Donald; Smith, A. David; Macdonald, Ian A.; Knight, Helen Miranda

doi:10.1016/j.neurobiolaging.2019.02.001

All Outputs (2)

Damaging coding variants within kainate receptor channel genes are enriched in individuals with schizophrenia, autism and intellectual disabilities (2019)
Journal Article

Schizophrenia (Scz), autism spectrum disorder (ASD) and intellectual disability are common complex neurodevelopmental disorders. Kainate receptors (KARs) are ionotropic glutamate ion channels involved in synaptic plasticity which are modulated by aux... Read More about Damaging coding variants within kainate receptor channel genes are enriched in individuals with schizophrenia, autism and intellectual disabilities.

Interaction of nutrition and genetics via DNMT3L-mediated DNA methylation determines cognitive decline (2019)
Journal Article

Low homocysteine levels and B vitamin treatment are reported to protect against declining cognitive health. Both B vitamins and homocysteine are involved in the production of S-adenosylmethionine, a universal methyl donor essential for the process of... Read More about Interaction of nutrition and genetics via DNMT3L-mediated DNA methylation determines cognitive decline.