Maternal nutrient restriction during early to mid gestation alters the relationship between insulin-like growth factor I and bodyweight at term in fetal sheep

Heasman, L.; Brameld, J.; Mostyn, A.; Budge, H.; Dawson, J.; Buttery, P.; Stephenson, T.; Symonds, M. E.

doi:10.1071/rd00115

Newborn infants with bilious vomiting: a national audit of neonatal transport services (2017)
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Objective: The precautionary approach to urgently investigate infants with bilious vomiting has increased the numbers referred to transport teams and tertiary surgical centres. The aim of this national UK audit was to quantify referrals, determine th... Read More about Newborn infants with bilious vomiting: a national audit of neonatal transport services.

Ontogeny and thermogenic role for sternal fat in female sheep (2017)
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The placenta, maternal diet and adipose tissue development in the newborn (2017)
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Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo (2017)
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© 2017 The Authors Introduction Brown adipose tissue (BAT) is a thermogenic organ with substantial metabolic capacity and has important roles in the maintenance of body weight and metabolism. Regulation of BAT is primarily mediated through the β-adre... Read More about Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo.

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Maintenance of thermal homeostasis within a tight range is regulated not only by a variety of internal and external cues but also by sex and biological age. The major organ responsible for adaptive thermogenesis is brown adipose tissue (BAT) and the... Read More about Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause?.

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Excess visceral adiposity, in particular that located adjacent to the heart and coronary arteries is associated with increased cardiovascular risk. In the pathophysiological state, dysfunctional adipose tissue secretes an array of factors modulating... Read More about ‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk.

Gene pathway development in human epicardial adipose tissue during early life (2016)
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Studies in rodents and newborn humans demonstrate the influence of brown adipose tissue (BAT) in temperature control and energy balance and a critical role in the regulation of body weight. Here, we obtained samples of epicardial adipose tissue (EAT)... Read More about Gene pathway development in human epicardial adipose tissue during early life.

Brown adipose tissue activation as measured by infrared thermography by mild anticipatory psychological stress in lean healthy females (2016)
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Brown adipose tissue (BAT) has been implicated in the pathogenesis of obesity, type 2 diabetes and the metabolic syndrome and is a potential therapeutic target. Brown adipose tissue can have a significant impact on energy balance and glucose homeosta... Read More about Brown adipose tissue activation as measured by infrared thermography by mild anticipatory psychological stress in lean healthy females.

Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes (2015)
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Context: Maternal obesity and gestational diabetes mellitus (GDM) can both contribute to adverse neonatal outcomes. The extent to which this may be mediated by differences in placental metabolism and nutrient transport remains to be determined.... Read More about Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes.

Glucagon increases energy expenditure independently of brown adipose tissue activation in humans (2015)
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Aims: To investigate, for a given energy expenditure (EE) rise, the differential effects of glucagon infusion and cold exposure on brown adipose tissue (BAT) activation in humans. Methods: Indirect calorimetry and supraclavicular thermography was pe... Read More about Glucagon increases energy expenditure independently of brown adipose tissue activation in humans.

Effect of pre- and postnatal growth and post-weaning activity on glucose metabolism in the offspring (2015)
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Maternal caloric restriction during late gestation reduces birth weight, but whether long-term adverse metabolic outcomes of intra-uterine growth retardation (IUGR) are dependent on either accelerated postnatal growth or exposure to an obesogenic env... Read More about Effect of pre- and postnatal growth and post-weaning activity on glucose metabolism in the offspring.

Body Mass Index as a Determinant of Brown Adipose Tissue Function in Healthy Children (2013)
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Objective To determine whether body mass index (BMI) percentile and ethnicity influence skin temperature overlying brown adipose tissue (BAT) depots in the supraclavicular region in healthy children. Study design Infrared thermography measured s... Read More about Body Mass Index as a Determinant of Brown Adipose Tissue Function in Healthy Children.

Sex differences in metabolic and adipose tissue responses to juvenile-onset obesity in sheep (2013)
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Sex is a major factor determining adipose tissue distribution and the subsequent adverse effects of obesity-related disease including type 2 diabetes. The role of gender on juvenile obesity and the accompanying metabolic and inflammatory responses is... Read More about Sex differences in metabolic and adipose tissue responses to juvenile-onset obesity in sheep.

Maternal nutrient restriction during late gestation and early postnatal growth in sheep differentially reset the control of energy metabolism in the gastric mucosa (2011)
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Fetal growth restriction followed by accelerated postnatal growth contributes to impaired metabolic function in adulthood. The extent to which these outcomes may be mediated centrally within the hypothalamus, as opposed to in the periphery within the... Read More about Maternal nutrient restriction during late gestation and early postnatal growth in sheep differentially reset the control of energy metabolism in the gastric mucosa.

Ontogeny and nutritional programming of mitochondrial proteins in the ovine kidney, liver and lung (2007)
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This study investigated the developmental and nutritional programming of two important mitochondrial proteins, namely voltage dependent anion channel (VDAC) and cytochrome c in the sheep kidney, liver and lung. The effect of maternal nutrient restric... Read More about Ontogeny and nutritional programming of mitochondrial proteins in the ovine kidney, liver and lung.

Ontogeny and nutritional programming of the hepatic growth hormone-insulin-like growth factor-prolactin axis in the sheep (2007)
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The liver is an important metabolic and endocrine organ in the fetus but the extent to which its hormone receptor (R) sensitivity is developmentally regulated in early life is not fully established. We, therefore, examined developmental changes in mR... Read More about Ontogeny and nutritional programming of the hepatic growth hormone-insulin-like growth factor-prolactin axis in the sheep.

Effect of maternal cold exposure and nutrient restriction on insulin-like growth factor sensitivity in adipose tissue of newborn sheep (2007)
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Adipose tissue mass in the newborn is determined in part by insulin-like growth factor (IGF)s, which are dependent on the maternal nutritional and metabolic environment during late gestation. The present study was designed to determine whether matern... Read More about Effect of maternal cold exposure and nutrient restriction on insulin-like growth factor sensitivity in adipose tissue of newborn sheep.

Maternal nutrient restriction during early to mid gestation alters the relationship between insulin-like growth factor I and bodyweight at term in fetal sheep (2000)
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The present study was designed to determine whether altered placental size, as a consequence of maternal nutrient restriction in sheep between 28 and 77 days gestation, is associated with a modified relationship between fetal weight or dimensions and... Read More about Maternal nutrient restriction during early to mid gestation alters the relationship between insulin-like growth factor I and bodyweight at term in fetal sheep.

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