All Outputs (9)

Bioengineered small extracellular vesicles deliver multiple SARS-CoV-2 antigenic fragments and drive a broad immunological response (2024)
Journal Article

The COVID-19 pandemic highlighted the clear risk that zoonotic viruses pose to global health and economies. The scientific community responded by developing several efficacious vaccines which were expedited by the global need for vaccines. The emerge... Read More about Bioengineered small extracellular vesicles deliver multiple SARS-CoV-2 antigenic fragments and drive a broad immunological response.

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches (2024)
Journal Article

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated bro... Read More about Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches.

Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies (2023)
Journal Article

Cerebrospinal fluid (CSF) is a clear, transparent fluid derived from blood plasma that protects the brain and spinal cord against mechanical shock, provides buoyancy, clears metabolic waste and transports extracellular components to remote sites in t... Read More about Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies.

Antibody response to four doses of SARS-CoV-2 vaccine in rare autoimmune rheumatic diseases: an observational study (2023)
Journal Article

Objective: Antibody responses to coronavirus disease 2019 (COVID-19) vaccines are reduced among immunocompromised patients but are not well quantified among people with rare disease. We conducted an observational study to evaluate the antibody respon... Read More about Antibody response to four doses of SARS-CoV-2 vaccine in rare autoimmune rheumatic diseases: an observational study.

Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release (2023)
Journal Article

The antiviral restriction factor, tetherin, blocks the release of several different families of enveloped viruses, including the Coronaviridae. Tetherin is an interferon-induced protein that forms parallel homodimers between the host cell and viral p... Read More about Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release.

Extracellular Vesicles Potentiate Medulloblastoma Metastasis in an EMMPRIN and MMP-2 Dependent Manner (2023)
Journal Article

Extracellular vesicles (EVs) have emerged as pivotal mediators of communication in the tumour microenvironment. More specifically, nanosized extracellular vesicles termed exosomes have been shown to contribute to the establishment of a premetastatic... Read More about Extracellular Vesicles Potentiate Medulloblastoma Metastasis in an EMMPRIN and MMP-2 Dependent Manner.

MEDB-64. Are Rab GTPases metastatic drivers in metastatic medulloblastoma? (2022)
Journal Article

Medulloblastoma is the most common malignant paediatric brain cancer with poorer prognosis related to the onset of metastasis. It has four molecular subgroups; Wingless (WNT), Sonic Hedgehog (SHH), group 3 and group 4, of which group 3 is the most li... Read More about MEDB-64. Are Rab GTPases metastatic drivers in metastatic medulloblastoma?.

A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma (2019)
Journal Article

© 2019, The Author(s). Three of the hallmarks of poor prognosis in paediatric ependymoma are drug resistance, local invasion and recurrence. We hypothesised that these hallmarks were due to the presence of a sub-population of cancer stem cells expres... Read More about A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma.

MBRS-21. EXTRACELLULAR VESICLES FROM METASTATIC MEDULLOBLASTOMA CELL LINES CARRY mRNAs KNOWN TO CORRELATE WITH METASTATIC DISEASE (2018)
Journal Article