All Outputs (8)

Bioengineered small extracellular vesicles deliver multiple SARS-CoV-2 antigenic fragments and drive a broad immunological response (2024)
Journal Article
Jackson, H. K., Long, H. M., Yam-Puc, J. C., Palmulli, R., Haigh, T. A., Gerber, P. P., …Edgar, J. R. (2024). Bioengineered small extracellular vesicles deliver multiple SARS-CoV-2 antigenic fragments and drive a broad immunological response. Journal of Extracellular Vesicles, 13(2), Article e12412. https://doi.org/10.1002/jev2.12412

The COVID-19 pandemic highlighted the clear risk that zoonotic viruses pose to global health and economies. The scientific community responded by developing several efficacious vaccines which were expedited by the global need for vaccines. The emerge... Read More about Bioengineered small extracellular vesicles deliver multiple SARS-CoV-2 antigenic fragments and drive a broad immunological response.

Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies (2023)
Journal Article
Sandau, U. S., Magaña, S. M., Costa, J., Nolan, J. P., Ikezu, T., Vella, L. J., …International Society for Extracellular Vesicles Cerebrospinal Fluid Task Force. (2023). Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies. Journal of Extracellular Vesicles, 13(1), Article 12397. https://doi.org/10.1002/jev2.12397

Cerebrospinal fluid (CSF) is a clear, transparent fluid derived from blood plasma that protects the brain and spinal cord against mechanical shock, provides buoyancy, clears metabolic waste and transports extracellular components to remote sites in t... Read More about Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies.

Antibody response to four doses of SARS-CoV-2 vaccine in rare autoimmune rheumatic diseases: an observational study (2023)
Journal Article
Gumber, L., Jackson, H., Gomez, N., Hopkins, G., Tucis, D., Chakravorty, M., …Fairclough, L. (2023). Antibody response to four doses of SARS-CoV-2 vaccine in rare autoimmune rheumatic diseases: an observational study. Rheumatology Advances in Practice, 7(3), Article rkad097. https://doi.org/10.1093/rap/rkad097

Objective Antibody response to COVID-19 vaccines are reduced among immunocompromised patients but are not well-quantified among people with rare disease. We conducted an observational study to evaluate the antibody responses to the booster SARS-CoV-... Read More about Antibody response to four doses of SARS-CoV-2 vaccine in rare autoimmune rheumatic diseases: an observational study.

Extracellular Vesicles Potentiate Medulloblastoma Metastasis in an EMMPRIN and MMP-2 Dependent Manner (2023)
Journal Article
Jackson, H. K., Mitoko, C., Linke, F., Macarthur, D., Kerr, I. D., & Coyle, B. (2023). Extracellular Vesicles Potentiate Medulloblastoma Metastasis in an EMMPRIN and MMP-2 Dependent Manner. Cancers, 15(9), Article 2601. https://doi.org/10.3390/cancers15092601

Extracellular vesicles (EVs) have emerged as pivotal mediators of communication in the tumour microenvironment. More specifically, nanosized extracellular vesicles termed exosomes have been shown to contribute to the establishment of a premetastatic... Read More about Extracellular Vesicles Potentiate Medulloblastoma Metastasis in an EMMPRIN and MMP-2 Dependent Manner.

Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination (2022)
Journal Article
Gumber, L., Gomez, N., Hopkins, G., Tucis, D., Bartlett, L., Ayling, K., …Fairclough, L. (2023). Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination. Rheumatology, 62(6), 2294-2303. https://doi.org/10.1093/rheumatology/keac574

Objectives: COVID-19 vaccine responses in rare autoimmune rheumatic diseases (RAIRD) remain poorly understood, in particular there is little known about whether people develop effective T-cell responses. We conducted a prospective cohort study to eva... Read More about Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination.

Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept (2022)
Journal Article
Vedhara, K., Ayling, K., Jia, R., Fairclough, L., Morling, J. R., Ball, J. K., …Tighe, P. (2022). Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept. Journal of Infectious Diseases, 225(12), 2137-2141. https://doi.org/10.1093/infdis/jiac006

Background: Psychological factors can influence susceptibility to viral infections. We examined whether such influences are evident in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: Participants (n=102) completed mea... Read More about Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept.

Immunocompromised children and young people are at no increased risk of severe COVID-19 (2021)
Journal Article
Chappell, H., Patel, R., Driessens, C., Tarr, A. W., Irving, W. L., Tighe, P. J., …de Graaf, H. (2022). Immunocompromised children and young people are at no increased risk of severe COVID-19. Journal of Infection, 84(1), 31-39. https://doi.org/10.1016/j.jinf.2021.11.005

Objectives: We aimed to prospectively describe the incidence and clinical spectrum of SARS-CoV-2 infection in immunocompromised paediatric patients in the UK. Methods: From March 2020 to 2021 weekly questionnaires were sent to immunocompromised paedi... Read More about Immunocompromised children and young people are at no increased risk of severe COVID-19.

A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma (2019)
Journal Article
Sabnis, D. H., Storer, L. C. D., Liu, J., Jackson, H. K., Kilday, J. P., Grundy, R. G., …Coyle, B. (2019). A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma. Scientific Reports, 9(1), 1-9. https://doi.org/10.1038/s41598-019-46700-z

© 2019, The Author(s). Three of the hallmarks of poor prognosis in paediatric ependymoma are drug resistance, local invasion and recurrence. We hypothesised that these hallmarks were due to the presence of a sub-population of cancer stem cells expres... Read More about A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma.