Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated

Atallah, Edmond; Grove, Jane I.; Crooks, Colin; Burden-Teh, Esther; Abhishek, Abhishek; Moreea, Sulleman; Jordan, Kelsey M.; Ala, Aftab; Hutchinson, David; Aspinall, Richard J.; Murphy, Ruth; Aithal, Guruprasad P.

doi:10.1016/j.jhep.2022.12.034

All Outputs (26)

Noninvasive assessment of liver disease severity in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (2023)
Journal Article

Background and Aims: We evaluated the diagnostic accuracy of simple, noninvasive tests (NITs) in NAFLD patients with type 2 diabetes (T2D). Methods and Results: This was an individual patient data meta-analysis of 1780 patients with biopsy-proven NAF... Read More about Noninvasive assessment of liver disease severity in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes.

Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans (2023)
Journal Article

Diagnosis of drug-induced liver injury (DILI) and its distinction from other liver diseases are significant challenges in drug development and clinical practice. Here, we identify, confirm, and replicate the biomarker performance characteristics of c... Read More about Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans.

Textbook Outcome After Trans-arterial Chemoembolization for Hepatocellular Carcinoma (2023)
Journal Article

Purpose Textbook Outcome (TO) is inclusive of quality indicators and it not been provided for trans-arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). Materials and Methods Data on treatment-naïve HCC patients receiving TACE... Read More about Textbook Outcome After Trans-arterial Chemoembolization for Hepatocellular Carcinoma.

Plasma Sphingoid Base Profiles of Patients Diagnosed with Intrinsic or Idiosyncratic Drug-induced Liver Injury (2023)
Journal Article

Sphingolipids are exceptionally diverse, comprising hundreds of unique species. The bulk of circulating sphingolipids are synthesized in the liver, thereby plasma sphingolipid profiles represent reliable surrogates of hepatic sphingolipid metabolism... Read More about Plasma Sphingoid Base Profiles of Patients Diagnosed with Intrinsic or Idiosyncratic Drug-induced Liver Injury.

Extra‐hepatic Morbidity and Mortality in Alcohol‐related Liver Disease: Systematic Review and Meta‐analysis (2023)
Journal Article

Background Alcohol use increases the risk of many conditions in addition to liver disease; patients with alcohol-related liver disease (ALD) are therefore at risk from both extra-hepatic and hepatic disease. Aims This review synthesises informat... Read More about Extra‐hepatic Morbidity and Mortality in Alcohol‐related Liver Disease: Systematic Review and Meta‐analysis.

Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated (2023)
Journal Article

Background & Aims: The risk of significant liver fibrosis from prolonged methotrexate (MTX) exposure has been estimated at around 5%, prompting intensive monitoring strategies. However, the evidence is derived from retrospective studies that under-re... Read More about Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated.