All Outputs (29)

CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity (2014)
Journal Article
Sheridan, G. K., Wdowicz, A., Pickering, M., Watters, O., Halley, P., O'Sullivan, N. C., …Murphy, K. J. (2014). CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity. Frontiers in Cellular Neuroscience, 8, Article 233. https://doi.org/10.3389/fncel.2014.00233

Several cytokines and chemokines are now known to play normal physiological roles in the brain where they act as key regulators of communication between neurons, glia, and microglia. In particular, cytokines and chemokines can affect cardinal cellula... Read More about CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity.

Theta-Burst Stimulation of Hippocampal Slices Induces Network-Level Calcium Oscillations and Activates Analogous Gene Transcription to Spatial Learning (2014)
Journal Article
Murphy, K. J., Sheridan, G. K., O'Connor, J. J., Moeendarbary, E., & Pickering, M. (2014). Theta-Burst Stimulation of Hippocampal Slices Induces Network-Level Calcium Oscillations and Activates Analogous Gene Transcription to Spatial Learning. PLoS ONE, 9(6), https://doi.org/10.1371/journal.pone.0100546

Over four decades ago, it was discovered that high-frequency stimulation of the dentate gyrus induces long-term potentiation (LTP) of synaptic transmission. LTP is believed to underlie how we process and code external stimuli before converting it to... Read More about Theta-Burst Stimulation of Hippocampal Slices Induces Network-Level Calcium Oscillations and Activates Analogous Gene Transcription to Spatial Learning.

Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations (2014)
Journal Article
Sheridan, G. K., & Dev, K. K. (2014). Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations. Scientific Reports, 4(1), https://doi.org/10.1038/srep05051

Fingolimod (FTY720) is an oral therapy for relapsing remitting multiple sclerosis (MS) and targets sphingosine 1-phosphate receptors (S1PRs). FTY720 also rescues animals from experimental autoimmune encephalomyelitis (EAE), an animal model of MS. The... Read More about Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations.

Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage (2013)
Journal Article
Sheridan, G. K., & Murphy, K. J. (2013). Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage. Open Biology, 3(12), Article 130181. https://doi.org/10.1098/rsob.130181

An essential aspect of normal brain function is the bidirectional interaction and communication between neurons and neighbouring glial cells. To this end, the brain has evolved ligand-receptor partnerships that facilitate crosstalk between different... Read More about Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage.

Pathway specific modulation of S1P1 receptor signalling in rat and human astrocytes (2013)
Journal Article
Healy, L. M., Sheridan, G. K., Pritchard, A. J., Rutkowska, A., Mullershausen, F., & Dev, K. K. (2013). Pathway specific modulation of S1P1 receptor signalling in rat and human astrocytes. British Journal of Pharmacology, 169(5), 1114-1129. https://doi.org/10.1111/bph.12207

Background and Purpose The sphingosine 1-phosphate receptor subtype 1 (S1P1R) is modulated by phosphorylated FTY720 (pFTY720), which causes S1P1R internalization preventing lymphocyte migration thus limiting autoimmune response. Studies indicate that... Read More about Pathway specific modulation of S1P1 receptor signalling in rat and human astrocytes.

S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures (2011)
Journal Article
Sheridan, G. K., & Dev, K. K. (2012). S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures. Glia, 60(3), 382-392. https://doi.org/10.1002/glia.22272

Sphingosine-1-phosphate receptors (S1PRs) are drug targets for the compound FTY720, which is the first oral therapy developed for treatment of relapsing-remitting multiple sclerosis. S1PRs play a variety of functional roles in the differentiation, pr... Read More about S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures.

AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity (2010)
Journal Article
McKee, A. G., Loscher, J. S., O'Sullivan, N. C., Chadderton, N., Palfi, A., Batti, L., …Murphy, K. J. (2010). AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity. Journal of Neurochemistry, 112(4), 991-1004. https://doi.org/10.1111/j.1471-4159.2009.06516.x

Long-term memory is formed by alterations in glutamate-dependent excitatory synaptic transmission, which is in turn regulated by synaptosomal protein of 25 kDa (SNAP-25), a key component of the soluble N-ethylmaleimide-sensitive factor attachment pro... Read More about AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity.

NF-?B activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations (2007)
Journal Article
Sheridan, G. K., Pickering, M., Twomey, C., Moynagh, P. N., O'Connor, J. J., & Murphy, K. J. (2007). NF-?B activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations. Learning and Memory, 14(8), 525-532. https://doi.org/10.1101/lm.590007

Hippocampal memory-associated synaptic plasticity is driven by a cascade of transcription and new protein synthesis. In vitro electrophysiological studies on acute hippocampal slices have elucidated much of what we know about this molecular cascade.... Read More about NF-?B activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations.

Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning (2006)
Journal Article
O'Sullivan, N. C., McGettigan, P. A., Sheridan, G. K., Pickering, M., Conboy, L., O'Connor, J. J., …Murphy, K. J. (2007). Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning. Journal of Neurochemistry, 101(4), 1085-1098. https://doi.org/10.1111/j.1471-4159.2006.04418.x

A learning event initiates a cascade of altered gene expression leading to synaptic remodelling within the hippocampal dentate gyrus, a structure vital to memory formation. To illuminate this transcriptional program of synaptic plasticity we used mic... Read More about Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning.