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Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn’s disease: long-term outcomes for 11 928 patients in the UK inflammatory bowel disease bioresource (2020)
Journal Article
Stournaras, E., Qian, W., Pappas, A., Hong, Y. Y., Shawky, R., Raine, T., & Parkes, M. (2020). Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn’s disease: long-term outcomes for 11 928 patients in the UK inflammatory bowel disease bioresource. Gut, 70(4), 677-686. https://doi.org/10.1136/gutjnl-2019-320185

Objective Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date, we assessed the long-ter... Read More about Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn’s disease: long-term outcomes for 11 928 patients in the UK inflammatory bowel disease bioresource.

Experiences of using vedolizumab in the treatment of inflammatory bowel disease in the East Midlands UK – a retrospective observational study (2020)
Journal Article
White, J. R., Din, S., Ingram, R. J. M., Foley, S., Alam, M. A., Robinson, R., …Moran, G. W. (2020). Experiences of using vedolizumab in the treatment of inflammatory bowel disease in the East Midlands UK – a retrospective observational study. Scandinavian Journal of Gastroenterology, 55(8), 907-916. https://doi.org/10.1080/00365521.2020.1790647

Purpose
Clinical trials have demonstrated efficacy of vedolizumab in ulcerative colitis (UC) and Crohn’s disease (CD). Further real-world data is needed to inform clinical practice. The primary outcome was to assess corticosteroid-free and clinical... Read More about Experiences of using vedolizumab in the treatment of inflammatory bowel disease in the East Midlands UK – a retrospective observational study.

Systematic review: the impact of inflammatory bowel disease-related fatigue on health-related quality of life (2020)
Journal Article
Radford, S. J., McGing, J., Czuber-Dochan, W., & Moran, G. (2021). Systematic review: the impact of inflammatory bowel disease-related fatigue on health-related quality of life. Frontline Gastroenterology, 12(1), 11-21. https://doi.org/10.1136/flgastro-2019-101355

Background: Fatigue is frequently reported in inflammatory bowel disease (IBD) and impacts on Health-Related Quality of Life (HRQoL). HRQoL has not been systematically reviewed in IBD fatigue.

Aim: To investigate what impact IBD fatigue has on HR... Read More about Systematic review: the impact of inflammatory bowel disease-related fatigue on health-related quality of life.

Profile of Tofacitinib in the Treatment of Ulcerative Colitis: An Evidence-Based Review of Recent Data (2019)
Journal Article
Varyani, F., Argyriou, K., Phillips, F., Tsakiridou, E., & Moran, G. W. (2019). Profile of Tofacitinib in the Treatment of Ulcerative Colitis: An Evidence-Based Review of Recent Data. Drug Design, Development and Therapy, 13, 4091-4105. https://doi.org/10.2147/dddt.s182891

Recent advances in the understanding of the pathophysiology of ulcerative colitis (UC) have led to the expansion of our therapeutic arsenal. Conventional treatment options, including aminosalicylates, corticosteroids, thiopurines, and calcineurin inh... Read More about Profile of Tofacitinib in the Treatment of Ulcerative Colitis: An Evidence-Based Review of Recent Data.

Physical activity and fatigue in adults with Inflammatory Bowel Disease (IBD): a systematic review (2019)
Journal Article
Radford, S. J., Janiszewski, H., & Moran, G. W. (2019). Physical activity and fatigue in adults with Inflammatory Bowel Disease (IBD): a systematic review. Gastrointestinal Nursing, 17(9), 16-21. https://doi.org/10.12968/gasn.2019.17.9.16

Background: Fatigue is frequently reported in inflammatory bowel disease (IBD). IBD has been shown to have an impact on, and be impacted by, physical activity levels in IBD patients, Yet, to date, there have been no systematic reviews considering the... Read More about Physical activity and fatigue in adults with Inflammatory Bowel Disease (IBD): a systematic review.

Infliximab induction regimens in steroid refractory acute severe colitis: a multi-centre retrospective cohort study with propensity score analysis (2019)
Journal Article
Sebastian, S., Myers, S., Argyriou, K., Martin, G., Los, L., Fiske, J., Ranjan, R., Cooper, B., Goodoory, V., Ching, H., Jayasooriya, N., Brooks, J., Dhar, A., Shenoy, A., Limdi, J., Butterworth, J., Allen, P., Samuel, S., Moran, G., Shenderey, R., …Raine, T. (2019). Infliximab induction regimens in steroid refractory acute severe colitis: a multi-centre retrospective cohort study with propensity score analysis. Alimentary Pharmacology and Therapeutics, 50(6), 675-683. https://doi.org/10.1111/apt.15456

Background:
Accelerated induction regimens of infliximab have been proposed to improve response rates in patients with steroid refractory acute severe colitis.

Aims:
We aimed to determine differences in outcome for acute severe ulcerative colit... Read More about Infliximab induction regimens in steroid refractory acute severe colitis: a multi-centre retrospective cohort study with propensity score analysis.

Practice pattern variability in the management of acute severe colitis: A UK provider survey (2019)
Journal Article
Sebastian, S., Lisle, J., Subramanian, S., Dhar, A., Shenoy, A., Limdi, J., …Kennedy, N. A. (2019). Practice pattern variability in the management of acute severe colitis: A UK provider survey. Frontline Gastroenterology, https://doi.org/10.1136/flgastro-2019-101277

© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. Introduction: Lack of comparative trial data on dosing regimens of infliximab in patients with acute severe ulcerative colitis (ASUC) failing... Read More about Practice pattern variability in the management of acute severe colitis: A UK provider survey.

Reduced skeletal muscle protein balance in paediatric Crohn’s disease (2019)
Journal Article
Davies, A., Nixon, A., Muhammed, R., Tsintzas, K., Kirkham, S., Stephens, F. B., & Moran, G. W. (2020). Reduced skeletal muscle protein balance in paediatric Crohn’s disease. Clinical Nutrition, 39(4), 1250-1257. https://doi.org/10.1016/j.clnu.2019.05.017

Background and Aims
An inability to respond to nutrition could be implicated in low muscle mass in Crohn’s disease. We aim to determine skeletal muscle metabolic response to feeding in Crohn’s disease and healthy volunteers.

Methods
Twenty asymp... Read More about Reduced skeletal muscle protein balance in paediatric Crohn’s disease.

Review article: managing the adverse events caused by anti-TNF therapy in inflammatory bowel disease (2019)
Journal Article
Shivaji, U. N., Sharratt, C. L., Thomas, T., Smith, S. C., Iacucci, M., Moran, G. W., Ghosh, S., & Bhala, N. (2019). Review article: managing the adverse events caused by anti-TNF therapy in inflammatory bowel disease. Alimentary Pharmacology and Therapeutics, 49(6), 664-680. https://doi.org/10.1111/apt.15097

Background: Biological therapy is currently widely used to treat inflammatory bowel disease (IBD). Infliximab, adalimumab and golimumab are currently licensed anti-TNF therapies. Biosimilar anti-TNF monoclonal antibodies are increasingly used. Anti-T... Read More about Review article: managing the adverse events caused by anti-TNF therapy in inflammatory bowel disease.

Does fecal calprotectin equally and accurately measure disease activity in small bowel and large bowel Crohn's disease? A systematic review (2019)
Journal Article
Simon, E. G., Wardle, R., Thi, A. A., Eldridge, J., Samuel, S., & Moran, G. W. (2019). Does fecal calprotectin equally and accurately measure disease activity in small bowel and large bowel Crohn's disease? A systematic review. Intestinal Research, 17(2), 160-170. https://doi.org/10.5217/ir.2018.00114

Fecal calprotectin (FC) is a highly sensitive disease activity biomarker in inflammatory bowel disease. However, there are conflicting reports on whether the diagnostic accuracy in Crohn’s disease is influenced by disease location. The aim of this st... Read More about Does fecal calprotectin equally and accurately measure disease activity in small bowel and large bowel Crohn's disease? A systematic review.

Acetarsol in the management of mesalazine refractory ulcerative proctitis: a tertiary-level care experience (2018)
Journal Article
Argyriou, K., Samuel, S., & Moran, G. W. (2019). Acetarsol in the management of mesalazine refractory ulcerative proctitis: a tertiary-level care experience. European Journal of Gastroenterology and Hepatology, 31(2), 183-186. https://doi.org/10.1097/MEG.0000000000001326

© 2018 Wolters Kluwer Health, Inc. All rights reserved. Background Mesalazine-refractory ulcerative proctitis is common, with a significant proportion of the patients requiring escalation to immunomodulators or biological therapy. Three small prelimi... Read More about Acetarsol in the management of mesalazine refractory ulcerative proctitis: a tertiary-level care experience.

Cine MRI assessment of motility in the unprepared small bowel in the fasting and fed state: beyond the breath-hold (2018)
Journal Article
Hoad, C., Marciani, L., Spiller, R., Gowland, P., & Moran, G. (2019). Cine MRI assessment of motility in the unprepared small bowel in the fasting and fed state: beyond the breath-hold. Neurogastroenterology and Motility, 31(1), e13466. https://doi.org/10.1111/nmo.13466

Background

The symptoms of functional bowel disorders are common in postprandial but investigations are generally undertaken in the fasted state using invasive procedures. MRI provides a noninvasive tool to study the gastrointestinal tract in an u... Read More about Cine MRI assessment of motility in the unprepared small bowel in the fasting and fed state: beyond the breath-hold.

Novel oral targeted therapies in inflammatory bowel disease (2018)
Journal Article
White, J. R., Philips, F., Monaghan, T. M., Fateen, W., Samuel, S., Ghosh, S., & Moran, G. W. (2018). Novel oral targeted therapies in inflammatory bowel disease. Alimentary Pharmacology and Therapeutics, 47(12), 1610-1622. https://doi.org/10.1111/apt.14669

Background: There is a great unmet clinical need for efficacious, tolerable, economical and orally administrated drugs for the treatment of inflammatory bowel disease (IBD). New therapeutic avenues have become possible including the development of me... Read More about Novel oral targeted therapies in inflammatory bowel disease.

An examination of appetite and disordered eating in active Crohn’s disease (2018)
Journal Article
Wardle, R., Thapaliya, G., Nowak, A., Radford, S., Dalton, M., Finlayson, G., & Moran, G. W. (2018). An examination of appetite and disordered eating in active Crohn’s disease. Journal of Crohn's and Colitis, 12(7), 819-825. https://doi.org/10.1093/ecco-jcc/jjy041

Background: Crohn’s disease (CD) patients suffer from nutritional deficiencies when in active disease. We aim to examine calorific intake, macronutrient choice and disordered eating behaviour in patients with active CD.
Methods: CD patients with ma... Read More about An examination of appetite and disordered eating in active Crohn’s disease.

Orbital inflammatory complications of Crohn’s disease: a rare case series (2018)
Journal Article
Monaghan, T. M., Albanese, G., Kaye, P., Thomas, J. D., Abercrombie, L., & Moran, G. W. (in press). Orbital inflammatory complications of Crohn’s disease: a rare case series. Clinical Medicine Insights: Gastroenterology, 11, https://doi.org/10.1177/1179552218757512

Orbital inflammatory disease is a rare ophthalmic manifestation of Crohn’s disease. Inflammation is characteristically non-specific, involving one or multiple structures of the orbit. Mechanisms of disease and optimal methods of treatment are poorly... Read More about Orbital inflammatory complications of Crohn’s disease: a rare case series.

Surgical rates for Crohn’s Disease are decreasing: a population-based time trend analysis and validation study (2017)
Journal Article
Ma, C., Moran, G. W., Benchimol, E. I., Targownik, L. E., Heitman, S. J., Hubbard, J. N., …Kaplan, G. G. (2017). Surgical rates for Crohn’s Disease are decreasing: a population-based time trend analysis and validation study. American Journal of Gastroenterology, 112, https://doi.org/10.1038/ajg.2017.394

Objectives:
Temporal changes for intestinal resections for Crohn’s disease (CD) are controversial. We validated administrative database codes for CD diagnosis and surgery in hospitalized patients and then evaluated temporal trends in CD surgical res... Read More about Surgical rates for Crohn’s Disease are decreasing: a population-based time trend analysis and validation study.

Tofacitinib in ulcerative colitis (2016)
Journal Article
Archer, T. P., Moran, G. W., & Ghosh, S. (2016). Tofacitinib in ulcerative colitis. Immunotherapy, 8(5), https://doi.org/10.2217/imt-2015-0031

Cytokines orchestrate immune and inflammatory responses involved in the pathogenesis of ulcerative colitis (UC). Protein kinases are essential for signal transduction in eukaryotic cells. Janus kinases (JAKs) are a family of protein tyrosine kinases... Read More about Tofacitinib in ulcerative colitis.