Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study

Sebastian, Shaji; Walker, Gareth J; Kennedy, Nicholas A; Conley, Thomas E; Patel, Kamal V; Subramanian, Sreedhar; Kent, Alexandra J; Segal, Jonathan P; Brookes, Matthew J; Bhala, Neeraj; Gonzalez, Haidee A; Hicks, Lucy C; Mehta, Shameer J; Lamb, Christopher A; Abdale, Shukri; Abbasi, Abdullah; Abusrewil, Anwar; Aghimien, Precious; Ahmed, Saeed; Ali, Akram; Ali, Amjad; Alkhoury, Jad; Allen, Patrick; Al-Rifaie, Ammar; Appleby, Richard; Arasaradnam, Ramesh; Arebi, Naila; Arms-Williams, Bradley; Ashraf, Muteeb; Au, Andrea; Avades, Tamar; Ayubi, Homira; Azhar, Saleha; Baillie, Samantha; Balarajah, Sharmili; Bancil, Aaron; Basit, Abdul; Bayati, Murad; Bell, Andrew; Berry, Alexander; Bhat, Shivaram; Bhattacharyya, Joya; Bishop, Sophia; Blackmore, Laura; Bond, Ashley; Borg-Bartolo, Simon; Botwright, Emma; Bouri, Sonia; Boyle, Stephen; Bradley, Neil; Brailsford, Fiona; Britton, Deborah; Brown, Caitlin; Butcher, Rhys; Butterworth, Jeffrey; Campbell, Rachel; Campbell, Roisin; Campbell, Iona; Carr, Ruth; Carter, Josiah; Cartlidge, Peter; Chandy, Rajiv; Chatten, Kelly; Chaudhary, Rakesh; Chee, Desmond; Cheesbrough, Jonathan; Churchhouse, Antonia; Chughtai, Sara; Clough, Jennie; Cole, Alexander; Cook, Johannah; Cooney, Rachel; Cotton, Sarah; Coulter, Archibald; Critchlow, Tamsin; Cuison, Frederic; Curran, Chris; Darie, Ana-Maria; Dart, Robin; Davwar, Pantong; Dawa, Kasamu Kabiru; Dhar, Anjan; Din, Shahida; Diong, Kok Leong; Disney, Benjamin; Dooks, Emma; Downey, Louise; D'Souza, Anita; Dyall, Lovesh; El Masri, Ali El Rida; Elias, Mary; Evans, Holli; Felwick, Richard; Finegan, Michael; Flanagan, Paul; Fofaria, Rishi; Fong, Steven Chung Ming; Fox, Richard; Fraser, Aileen; Frunza, Christian; Ghodeif, Alhassan; Ghosh, Nivedita; Gilroy, Leah; Good, Larissa; Gordon, John; Grasso, Nicola; Guéroult, Aurelién M; Gulliver, James; Guthrie, Sarah; Gwiggner, Markus; Hanna, Mina; Harlow, Christopher; Harrison, Wendy; Hart, Ailsa; Hawthorne, Barney; Henshaw, Julie; Herdman-Grant, Rosaleen; Hooper, Patricia; Howard, Willow; Hussain, Nasir; Hutton, Thomas; Htun, Aye Mya; Irving, Peter; Jagdish, Reema; Javed, Anum; Javed, Asima; Jayasooriya, Nishani; Johnson, Matthew; Johnston, Emma; Jones, Gareth-Rhys; Kanagasundaram, Cynthia; Karagkouni, Fotein; Kemp, Karen; Kemp, Cheryl; Khalil, Hesham; Khan, Najeebullah; Khasawneh, Mais; Khurshid, Bilal; King, Andrew; Kirkham, Beverley; Kirkham, Fiona; Kokwaro, Flora; Korani, Mohamed; Koumoutsos, Ioannis; Kumar, Aditi; Kuzhiyanjal, Anish John Kuriakose; Lakeland, Martyn; Laverick, Sophie; Lees, Charlie; Levell, Emma; Levison, Scott; Lim, Samuel; Lim, Yuen-Hui; Limdi, Jimmy; Lindsay, James Oliver; Lisle, Jessica; Lobo, Alan; Luber, Raphael; Lucaciu, Laura; Lyne, Holly; MacDonald, Jonathan; Mahalingam, Aarani; Mahgoub, Sara; Malakar, Ridhima; Marley, Fenella; Mason, Joy; Mazhar, Zia; McCaughan, Hannah; Naughton, Tracy; McCulloch, Adam; McIlwaine, Stuart; Meah, Nirmol; Mebarek, Leila; Mendall, Mike; Meiarasu, Radharetnas; Mir, Nasir; Mills, Tilly; Milton, Jentus; Moffat, Victoria; Moran, Gordon W; Morris, Liam; Morrison, Gary; Morrison, Graham; Mulligan, Robert; Murray, Charles; Murray, Jennifer; Musharaf, Mutwakil; Myers, Sally; Naeck-Boolauky, Pineshwari; Naranjo, Andres; Navaratnam, Janardhan; Naylor, Deanna; Nixon, Emma; Nixon, Kirsty; Nooredinvand, Hesam Ahmadi; Nosegbe, Uche; Olabintan, Olaolu; Ong Ming San, Elaine; Okpeh, Comfort; Owen, Hayley; Owen, Ruth; Palmer-Jones, Christopher; Peddada, Kalyan; Peerally, Mohammad; Perkins, Rebecca; Phillips, Frank; Pohl, Keith; Pollok, Richard; Powell, Nick; Qayyum, Farah; Qurashi, Maria; Quraishi, Mohammed Nabil; Ratcliffe, Elizabeth; Radford, Shellie; Rahmany, Sohail; Ramadan, Hanin; Ramadas, Arvind; Reddington, Anne; Riley, Tom; Rimmer, Peter; Ritchie, Susan; Roscoe, Jacqueline; Rosiou, Konstantina; Rowland, Siobhan; Sabine, Joseph; Saifuddin, Aamir; Samaan, Mark; Sarkar, Priya; Sarwar, Shahzad; Sasegbon, Ayodele; Saunders, Jayne; Sebepos-Rogers, Gregory; Seenan, John Paul; Selinger, Christian; Serna, Solange; Sethi, Sonika; Shale, Matthew; Shenderey, Richard; Shenoy, Achuth; Sherifat, Yousuf; Sheth, Roosey; Siakavellas, Spyros; Sikafi, Rafid; Singh, Amar; Singh, Salil; Singh, Updesh; Sivaji, Ganesh; Smith, Philip; Speight, R Alexander; Spence, Andy; Stansfield, Catherine; Steed, Helen; Suseeharan, Kishaani; Tabuso, Maria; Taucius, Donatas; Taylor, Joanne; Thakor, Amit; Tham, Tony; Townsend, Gill; Townsend, Tristan; Troth, Thomas; Tunney, Ruth; Turner, Kelly; Umar, Nosheen; Vakeeswarasarma, Vithushan; Verma, Ajay M; Wallace, Hazel; Wallis, Katharina; Walton, Hannah; Wang, Bo; Warner, Eleanor; Watson, Callum; Watson, Eleanor; Wen, Susie; Widlak, Monika; Williams, Maureen; Woods, Amy; Younge, Lisa; Zafar, Mansoor

doi:10.1016/s2468-1253(21)00016-9

All Outputs (25)

Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab (2022)
Journal Article

Anti tumour necrosis factor (anti-TNF) drugs increase the risk of serious respiratory infection and impair protective immunity following pneumococcal and influenza vaccination. Here we report SARS-CoV-2 vaccine-induced immune responses and breakthrou... Read More about Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab.

Ambulatory care management of 69 patients with acute severe ulcerative colitis in comparison to 695 inpatients: insights from a multicentre UK cohort study (2022)
Journal Article

Introduction Acute severe ulcerative colitis (ASUC) traditionally requires inpatient hospital management for intravenous therapies and/or colectomy. Ambulatory ASUC care has not yet been evaluated in large cohorts. Aims We used data from PROTECT, a U... Read More about Ambulatory care management of 69 patients with acute severe ulcerative colitis in comparison to 695 inpatients: insights from a multicentre UK cohort study.

Current Use of EEN in Pre-Operative Optimisation in Crohn’s Disease (2021)
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Despite the increasing array of medications available for the treatment of Crohn’s disease and a focus on mucosal healing, approximately 35% of patients with Crohn’s disease undergo bowel surgery at some stage. The importance of nutritional optimisat... Read More about Current Use of EEN in Pre-Operative Optimisation in Crohn’s Disease.

Inflammatory bowel disease clinical service recovery during the COVID-19 pandemic (2021)
Journal Article

Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study (2021)
Journal Article

Background There is a paucity of evidence to support safe and effective management of patients with acute severe ulcerative colitis during the COVID-19 pandemic. We sought to identify alterations to established conventional evidence-based management... Read More about Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study.