Effect of polymer topology on non-covalent polymer-protein complexation: miktoarm versus linear mPEG-poly(glutamic acid) copolymers

Nieto-Orellana, Alejandro; Di Antonio, Marco; Conte, Claudia; Falcone, Franco H.; Bosquillon, Cynthia; Childerhouse, Nick; Mantovani, Giuseppe; Stolnik, Snow

doi:10.1039/C7PY00169J

All Outputs (3)

Control of targeting ligand display by pH-responsive polymers on gold nanoparticles mediates selective entry into cancer cells (2017)
Journal Article

Selective targeting of cells for intracellular delivery of therapeutics represents a major challenge for pharmaceutical intervention in disease. Here we show pH triggered receptor-mediated endocytosis of nanoparticles via surface ligand exposure. Gol... Read More about Control of targeting ligand display by pH-responsive polymers on gold nanoparticles mediates selective entry into cancer cells.

Polymers for binding of the gram-positive oral pathogen Streptococcus mutans (2017)
Journal Article

Streptococcus mutans is the most significant pathogenic bacterium implicated in the formation of dental caries and, both directly and indirectly, has been associated with severe conditions such as multiple sclerosis, cerebrovascular and peripheral ar... Read More about Polymers for binding of the gram-positive oral pathogen Streptococcus mutans.

Effect of polymer topology on non-covalent polymer-protein complexation: miktoarm versus linear mPEG-poly(glutamic acid) copolymers (2017)
Journal Article

Non-covalent polymer-protein conjugation is emerging as a potential route to improve pharmacokinetics and pharmacodynamics of protein therapeutics. In this study, a family of structurally related block copolymers of mPEG2k - poly(glutamic acid) with... Read More about Effect of polymer topology on non-covalent polymer-protein complexation: miktoarm versus linear mPEG-poly(glutamic acid) copolymers.