All Outputs (90)

High-throughput functional curation of cellular electrophysiology models (2011)
Journal Article

Effective reuse of a quantitative mathematical model requires not just access to curated versions of the model equations, but also an understanding of the functional capabilities of the model, and the advisable scope of its application. To enable thi... Read More about High-throughput functional curation of cellular electrophysiology models.

Novel approaches to assessing cardiac safety - Proceedings of a workshop: Regulators, industry and academia discuss the future of in silico cardiac modelling to predict the proarrhythmic safety of drugs (2011)
Journal Article

The significant effect of the choice of ionic current integration method in cardiac electro-physiological simulations (2011)
Journal Article

Finite element (FE) cardiac electro-physiology solvers commonly have ionic current determined at mesh nodes but required element interiors. We consider two interpolation approaches: (i) ionic current interpolation (ICI), where nodal ionic currents ar... Read More about The significant effect of the choice of ionic current integration method in cardiac electro-physiological simulations.

Simulation of multiple ion channel block provides improved prediction of compounds’ clinical torsadogenic risk (2011)
Journal Article

© 2011 The Author. Aims The level of inhibition of the human Ether - go-go-related gene (hERG) channel is one of the earliest preclinical markers used to predict the risk of a compound causing Torsade-de-Pointes (TdP) arrhythmias. While avoiding the... Read More about Simulation of multiple ion channel block provides improved prediction of compounds’ clinical torsadogenic risk.

A hybrid approach to multi-scale modelling of cancer (2010)
Journal Article

In this paper, we review multi-scale models of solid tumour growth and discuss a middleout framework that tracks individual cells. By focusing on the cellular dynamics of a healthy colorectal crypt and its invasion by mutant, cancerous cells, we comp... Read More about A hybrid approach to multi-scale modelling of cancer.

Modelling spatially regulated ?-catenin dynamics and invasion in intestinal crypts (2010)
Journal Article

Experimental data (e.g., genetic lineage and cell population studies) on intestinal crypts reveal that regulatory features of crypt behavior, such as control via morphogen gradients, are remarkably well conserved among numerous organisms (e.g., from... Read More about Modelling spatially regulated ?-catenin dynamics and invasion in intestinal crypts.

An integrative computational model for intestinal tissue renewal (2009)
Journal Article

Objectives: The luminal surface of the gut is lined with a monolayer of epithelial cells that acts as a nutrient absorptive engine and protective barrier. To maintain its integrity and functionality, the epithelium is renewed every few days. Theoreti... Read More about An integrative computational model for intestinal tissue renewal.

Chaste: A test-driven approach to software development for biological modelling (2009)
Journal Article

Chaste ('Cancer, heart and soft-tissue environment') is a software library and a set of test suites for computational simulations in the domain of biology. Current functionality has arisen from modelling in the fields of cancer, cardiac physiology an... Read More about Chaste: A test-driven approach to software development for biological modelling.

A multiple timescale analysis of a mathematical model of the Wnt/?-catenin signalling pathway (2009)
Journal Article

The Wnt signalling pathway is involved in stem cell maintenance, differentiation and tissue development. Its disregulation has also been implicated in many cancers. β-catenin is a protein that regulates both transcription of many genes and cell-cell... Read More about A multiple timescale analysis of a mathematical model of the Wnt/?-catenin signalling pathway.

A computational study of discrete mechanical tissue models (2009)
Journal Article

A computational study of discrete 'cell-centre' approaches to modelling the evolution of a collection of cells is undertaken. The study focuses on the mechanical aspects of the tissue, in order to separate the passive mechanical response of the model... Read More about A computational study of discrete mechanical tissue models.