All Outputs (4)

Modelling the Effect of Intracellular Calcium in the Rundown of L-Type Calcium Current (2022)
Conference Proceeding

The L-type calcium current (ICaL) is a key current of the heart playing an important role in the contraction of the cardiomyocyte. Patch-clamp recordings of ionic currents can be associated with a reduction of the current magnitude with time (termed... Read More about Modelling the Effect of Intracellular Calcium in the Rundown of L-Type Calcium Current.

Normalisation of Action Potential Data Recorded with Sharp Electrodes Maximises Its Utility for Model Development (2022)
Conference Proceeding

In silico models of cardiomyocyte electrophysiology describe the various ionic currents and fluxes that lead to the formation of action potentials (APs). Experimental data used to create such models can be recorded in adult human cardiac trabeculae u... Read More about Normalisation of Action Potential Data Recorded with Sharp Electrodes Maximises Its Utility for Model Development.

Development, Implementation and Testing of a Multicellular Dynamic Action Potential Clamp Simulator for Drug Cardiac Safety Assessment (2020)
Conference Proceeding

© 2020 Creative Commons; the authors hold their copyright. As drugs can be multichannel blockers it is important to assess their cardiac safety taking into account multiple currents. In silico action potential (AP) models have been proposed for being... Read More about Development, Implementation and Testing of a Multicellular Dynamic Action Potential Clamp Simulator for Drug Cardiac Safety Assessment.

Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated guinea pig ventricular myocytes (2010)
Conference Proceeding

Experimental action potential (AP) recordings in isolated ventricular myoctes display significant temporal beatto- beat variability in morphology and duration. Furthermore, significant cell-to-cell differences in AP also exist even for isolated cells... Read More about Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated guinea pig ventricular myocytes.