All Outputs (5)

Stroking modulates noxious-evoked brain activity in human infants (2018)
Journal Article

A subclass of C fibre sensory neurons found in hairy skin are activated by gentle touch [1] and respond optimally to stroking at ∼1–10 cm/s, serving a protective function by promoting affiliative behaviours. In adult humans, stimulation of these C-ta... Read More about Stroking modulates noxious-evoked brain activity in human infants.

Lamina-specific population encoding of cutaneous signals in the spinal dorsal horn using multi-electrode arrays (2018)
Journal Article

The dorsal spinal cord (DH) is a complex laminar structure integrating peripheral signals into the central nervous system. Spinal somatosensory processing is commonly measured electrophysiologically in vivo by recording the activity of individual Wid... Read More about Lamina-specific population encoding of cutaneous signals in the spinal dorsal horn using multi-electrode arrays.

The influence of the descending pain modulatory system on infant pain-related brain activity (2018)
Journal Article

The descending pain modulatory system (DPMS) constitutes a network of widely distributed brain regions whose integrated function is essential for effective modulation of sensory input to the central nervous system and behavioural responses to pain. A... Read More about The influence of the descending pain modulatory system on infant pain-related brain activity.

Differential contributions of peripheral and central mechanisms to pain in a rodent model of osteoarthritis (2018)
Journal Article

The mechanisms underlying the transition from acute nociceptive pain to centrally maintained chronic pain are not clear. We have studied the contributions of the peripheral and central nervous systems during the development of osteoarthritis (OA) pai... Read More about Differential contributions of peripheral and central mechanisms to pain in a rodent model of osteoarthritis.

The peptide PnPP-19, a spider toxin derivative, activates ?-opioid receptors and modulates calcium channels (2018)
Journal Article

The synthetic peptide PnPP-19 comprehends 19 amino acid residues and it represents part of the primary structure of the toxin ?-CNTX-Pn1c (PnTx2-6), isolated from the venom of the spider Phoneutria nigriventer. Behavioural tests suggest that PnPP-19... Read More about The peptide PnPP-19, a spider toxin derivative, activates ?-opioid receptors and modulates calcium channels.